The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Regression of Electrocardiographic Left Ventricular Hypertrophy by Losartan Versus Atenolol: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
Abstract
Background— Electrocardiographic left ventricular hypertrophy (LVH) predicts cardiovascular morbidity and mortality, and regression of ECG LVH may predict improved prognosis in hypertensive patients. However, uncertainty persists as to how best to regress ECG LVH. Methods and Results— Regression of ECG LVH with losartan versus atenolol therapy was assessed in 9193 hypertensive patients with ECG LVH by Sokolow-Lyon voltage or Cornell voltage-duration product criteria enrolled in the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study. Patients had ECGs at study baseline and after 6 months, 1, 2, 3, 4, and 5 years of blinded losartan-based or atenolol-based therapy. After 6 months’ follow-up, adjusting for baseline ECG LVH levels, baseline and in-treatment systolic and diastolic pressures, and for diuretic therapy, losartan-based therapy was associated with greater regression of both Cornell product (adjusted means, −200 versus −69 mm · ms, P <0.001) and Sokolow-Lyon voltage (−2.5 versus −0.7 mm, P <0.001) than was atenolol-based therapy. Greater regression of ECG LVH persisted at each subsequent annual evaluation in the losartan-treated group, with between 140 and 164 mm · ms greater mean reductions in Cornell product and from 1.7 to 2.2 mm greater mean reductions in Sokolow-Lyon voltage (all P <0.001). The effect of losartan was consistent across subgroups defined by gender, age, ethnicity, and diabetes. Conclusions— After adjusting for baseline and in-treatment blood pressure and baseline severity of ECG LVH, losartan-based antihypertensive therapy resulted in greater regression of ECG LVH by Cornell voltage-duration product and Sokolow-Lyon voltage criteria than did atenolol-based therapy. These findings support the value of angiotensin receptor blockade with losartan for reversing ECG LVH.
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Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Dahlöf, B., Devereux, R. B., Kjeldsen, S. E., Julius, S., Beevers, G., de Faire, U., Fyhrquist, F., Ibsen, H., Kristiansson, K., Lederballe-Pedersen, O., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08089-3 · Cited by 5,407
Self-citationSokolow, M., & Lyon, T. P. (1949) · American Heart Journal · doi:10.1016/0002-8703(49)90562-1 · Cited by 1,980
Neaton, J. D. (1993) · JAMA · doi:10.1001/jama.270.6.713 · Cited by 946
Okin, P. M. (2004) · JAMA · doi:10.1001/jama.292.19.2343 · Cited by 663
Self-citationPrognostic Significance of Serial Changes in Left Ventricular Mass in Essential Hypertension
Verdecchia, P., Schillaci, G., Borgioni, C., Ciucci, A., Gattobigio, R., Zampi, I., Reboldi, G., & Porcellati, C. (1998) · Circulation · doi:10.1161/01.cir.97.1.48 · Cited by 655
Levy, D., Salomon, M., D'Agostino, R. B., Belanger, A. J., & Kannel, W. B. (1994) · Circulation · doi:10.1161/01.cir.90.4.1786 · Cited by 619
Mathew, J., Sleight, P., Lonn, E., Johnstone, D., Pogue, J., Yi, Q., Bosch, J., Sussex, B., Probstfield, J., & Yusuf, S. (2001) · Circulation · doi:10.1161/hc3901.096700 · Cited by 557
Continuous Relation Between Left Ventricular Mass and Cardiovascular Risk in Essential Hypertension
Schillaci, G., Verdecchia, P., Porcellati, C., Cuccurullo, O., Cosco, C., & Perticone, F. (2000) · Hypertension · doi:10.1161/01.hyp.35.2.580 · Cited by 530
Okin, P. M., Roman, M. J., Devereux, R. B., & Kligfield, P. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00371-v · Cited by 395
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(2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,655
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655
Self-citationAuthors/Task Force Members:, Mancia, G., De Backer, G., Dominiczak, A., Cifkova, R., Fagard, R., Germano, G., Grassi, G., Heagerty, A. M., Kjeldsen, S. E., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehm236 · Cited by 2,384
Self-citationMancia, G., Laurent, S., Agabiti-Rosei, E., Ambrosioni, E., Burnier, M., Caulfield, M. J., Cifkova, R., Clément, D., Coca, A., Dominiczak, A., et al. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e328333146d · Cited by 1,643
Self-citationAHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram
Rautaharju, P. M., Surawicz, B., & Gettes, L. S. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.014 · Cited by 1,016
Metadata
- Authors
- Okin, P. M., Devereux, R. B., Jern, S., Kjeldsen, S. E., Julius, S., Nieminen, M. S., Snapinn, S., Harris, K. E., Aurup, P., Edelman, J. M., & Dahlöf, B.
- Venue
- Circulation
- Published
- 2003-08-12
- Volume
- 108
- Issue
- 6
- Pages
- 684-690
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2151423733
- Cited by
- 257
- References
- 24
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Okin, P. M., Devereux, R. B., Jern, S., Kjeldsen, S. E., Julius, S., Nieminen, M. S., Snapinn, S., Harris, K. E., Aurup, P., Edelman, J. M., & Dahlöf, B. (2003). Regression of Electrocardiographic Left Ventricular Hypertrophy by Losartan Versus Atenolol: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study. Circulation. https://doi.org/10.1161/01.cir.0000083724.28630.c3
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