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Cited by 521

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Mapping and Ablation of Ventricular Fibrillation Associated With Long-QT and Brugada Syndromes

Open access
Haïssaguerre, Michel, Extramiana, Fabrice, Hocini, Mélèze, Cauchemez, Bruno, Jaïs, Pierre, Cabrera, Jose Angel, Farre, Geronimo, Leenhardt, Antoine, Sanders, Prashanthan, Scavée, Christophe, Hsu, Li-Fern, Weerasooriya, Rukshen, Shah, Dipen C., Frank, Robert, Maury, Philippe, Delay, Marc, Garrigue, Stéphane, Clémenty, Jacques·2003·Circulation

Abstract

Background— The long-QT and Brugada syndromes are important substrates of malignant ventricular arrhythmia. The feasibility of mapping and ablation of ventricular arrhythmias in these conditions has not been reported. Methods and Results— Seven patients (4 men; age, 38±7 years; 4 with long-QT and 3 with Brugada syndrome) with episodes of ventricular fibrillation or polymorphic ventricular tachycardia and frequent isolated or repetitive premature beats were studied. These premature beats were observed to trigger ventricular arrhythmias and were localized by mapping the earliest endocardial activity. In 4 patients, premature beats originated from the peripheral right (1 Brugada) or left (3 long-QT) Purkinje conducting system and were associated with variable Purkinje-to-muscle conduction times (30 to 110 ms). In the remaining 3 patients, premature beats originated from the right ventricular outflow tract, being 25 to 40 ms ahead of the QRS. The accuracy of mapping was confirmed by acute elimination of premature beats after 12±6 minutes of radiofrequency applications. During a follow-up of 17±17 months using ambulatory monitoring and defibrillator memory interrogation, no patients had recurrence of symptomatic ventricular arrhythmia but 1 had persistent premature beats. Conclusion— Triggers from the Purkinje arborization or the right ventricular outflow tract have a crucial role in initiating ventricular fibrillation associated with the long-QT and Brugada syndromes. These can be eliminated by focal radiofrequency ablation.

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Metadata

Authors
Haïssaguerre, M., Extramiana, F., Hocini, M., Cauchemez, B., Jaïs, P., Cabrera, J. A., Farre, G., Leenhardt, A., Sanders, P., Scavée, C., Hsu, L.-F., Weerasooriya, R., Shah, D. C., Frank, R., Maury, P., Delay, M., Garrigue, S., & Clémenty, J.
Venue
Circulation
Published
2003-08-26
Volume
108
Issue
8
Pages
925-928
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2145253150
Cited by
521
References
21
FWCI
14.88
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Mapping and Ablation of Ventricular Fibrillation Associated With Long-QT and Brugada Syndromes. https://app.cochat.ai/papers/10.1161/01.cir.0000088781.99943.95
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Haïssaguerre, M., Extramiana, F., Hocini, M., Cauchemez, B., Jaïs, P., Cabrera, J. A., Farre, G., Leenhardt, A., Sanders, P., Scavée, C., Hsu, L.-F., Weerasooriya, R., Shah, D. C., Frank, R., Maury, P., Delay, M., Garrigue, S., & Clémenty, J. (2003). Mapping and Ablation of Ventricular Fibrillation Associated With Long-QT and Brugada Syndromes. Circulation. https://doi.org/10.1161/01.cir.0000088781.99943.95

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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