The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Ascorbic Acid Prevents Contrast-Mediated Nephropathy in Patients With Renal Dysfunction Undergoing Coronary Angiography or Intervention
Open accessAbstract
Background— Contrast agents can cause a reduction in renal function that may be due to the generation of reactive oxygen species. Conflicting evidence suggests that administration of the antioxidant acetylcysteine prevents this renal impairment. The action of other antioxidant agents has not been investigated. Methods and Results— We conducted a randomized, double-blind, placebo-controlled trial of ascorbic acid in 231 patients with a serum creatinine concentration ≥1.2 mg/dL who underwent coronary angiography and/or intervention. Ascorbic acid, 3 g at least 2 hours before the procedure and 2 g in the night and the morning after the procedure, or placebo was administered orally. Contrast-mediated nephropathy was defined by an absolute increase of serum creatinine ≥0.5 mg/dL or a relative increase of ≥25% measured 2 to 5 days after the procedure. Contrast-mediated nephropathy occurred in 11 of the 118 patients (9%) in the ascorbic acid group and in 23 of the 113 patients (20%) in the placebo group (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.17 to 0.85; P =0.02). The mean serum creatinine concentration increased significantly in the placebo group (from 1.36±0.50 to 1.50±0.54 mg/dL, P <0.001) and nonsignificantly in the ascorbic acid group (from 1.46±0.52 to 1.52±0.64 mg/dL, P =0.07). The mean increase in serum creatinine concentration was greater in the placebo group than in the ascorbic acid group (difference of 0.09 mg/dL; 95% CI, 0.00 to 0.17; P =0.049). Conclusions— Prophylactic oral administration of ascorbic acid may protect against contrast-mediated nephropathy in high-risk patients undergoing a coronary procedure.
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Cites
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Vitamin C in Human Health and Disease Is Still a Mystery? An Overview
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Cited by
Bellomo, R., Kellum, J. A., & Ronco, C. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61454-2 · Cited by 2,598
Calzavacca, P., Licari, E., & Bellomo, R. (2010) · Surgical Intensive Care Medicine · doi:10.1007/978-0-387-77893-8_38 · Cited by 533
Mapping and Ablation of Ventricular Fibrillation Associated With Long-QT and Brugada Syndromes
Haïssaguerre, M., Extramiana, F., Hocini, M., Cauchemez, B., Jaïs, P., Cabrera, J. A., Farre, G., Leenhardt, A., Sanders, P., Scavée, C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000088781.99943.95 · Cited by 521
Contrast-Induced Nephropathy: A Clinical and Evidence-Based Approach
Tepel, M., Aspelin, P., & Lameire, N. (2006) · Circulation · doi:10.1161/circulationaha.105.595090 · Cited by 506
Nephropathy induced by contrast media: pathogenesis, risk factors and preventive strategies
Goldenberg, I. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.1040847 · Cited by 375
Metadata
- Authors
- Spargias, K., Alexopoulos, E., Kyrzopoulos, S., Iacovis, P., Greenwood, D. C., Manginas, A., Voudris, V., Pavlides, G., Buller, C. E., Kremastinos, D., & Cokkinos, D. V.
- Venue
- Circulation
- Published
- 2004-11-02
- Volume
- 110
- Issue
- 18
- Pages
- 2837-2842
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2143687264
- Cited by
- 317
- References
- 36
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Spargias, K., Alexopoulos, E., Kyrzopoulos, S., Iacovis, P., Greenwood, D. C., Manginas, A., Voudris, V., Pavlides, G., Buller, C. E., Kremastinos, D., & Cokkinos, D. V. (2004). Ascorbic Acid Prevents Contrast-Mediated Nephropathy in Patients With Renal Dysfunction Undergoing Coronary Angiography or Intervention. Circulation. https://doi.org/10.1161/01.cir.0000146396.19081.73
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
