Cited by 2,592Air Quality and Health ImpactsIndoor Air Quality and Microbial ExposureEnergy and Environment Impacts

The DOI matches its Crossref record, with a small difference in title or year; 43 of the 43 references it cites were found in a registry or an index.

Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease

Pope, C. Arden, Burnett, Richard T., Thurston, George D., Thun, Michael J., Calle, Eugenia E., Krewski, Daniel, Godleski, John J.·2004·Circulation

DOI 10.1161/01.cir.0000108927.80044.7f

Open this paper in CoChat — free account

Abstract

Background— Epidemiologic studies have linked long-term exposure to fine particulate matter air pollution (PM) to broad cause-of-death mortality. Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality. Methods and Results— General pathophysiological pathways linking long-term PM exposure with mortality and expected patterns of PM mortality with specific causes of death were proposed a priori. Vital status, risk factor, and cause-of-death data, collected by the American Cancer Society as part of the Cancer Prevention II study, were linked with air pollution data from United States metropolitan areas. Cox Proportional Hazard regression models were used to estimate PM-mortality associations with specific causes of death. Long-term PM exposures were most strongly associated with mortality attributable to ischemic heart disease, dysrhythmias, heart failure, and cardiac arrest. For these cardiovascular causes of death, a 10-μg/m 3 elevation in fine PM was associated with 8% to 18% increases in mortality risk, with comparable or larger risks being observed for smokers relative to nonsmokers. Mortality attributable to respiratory disease had relatively weak associations. Conclusions— Fine particulate air pollution is a risk factor for cause-specific cardiovascular disease mortality via mechanisms that likely include pulmonary and systemic inflammation, accelerated atherosclerosis, and altered cardiac autonomic function. Although smoking is a much larger risk factor for cardiovascular disease mortality, exposure to fine PM imposes additional effects that seem to be at least additive to if not synergistic with smoking.

Integrity signals

Registry

Crossref · 10.1161/01.cir.0000108927.80044.7f

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
Pope III, C. A. (2002) · JAMA · doi:10.1001/jama.287.9.1132 · Cited by 8,447
Self-citation
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Self-citation
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Air pollution and health
Brunekreef, B., & Holgate, S. T. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11274-8 · Cited by 4,701
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422
Counting Processes and Survival Analysis.
Dabrowska, D. M., Fleming, T. R., & Harrington, D. P. (1992) · Journal of the American Statistical Association · doi:10.2307/2290673 · Cited by 2,287
Increased Particulate Air Pollution and the Triggering of Myocardial Infarction
Peters, A., Dockery, D. W., Muller, J. E., & Mittleman, M. A. (2001) · Circulation · doi:10.1161/01.cir.103.23.2810 · Cited by 1,479
Short-Term Heart Rate Variability Strongly Predicts Sudden Cardiac Death in Chronic Heart Failure Patients
La Rovere, M. T., Pinna, G. D., Maestri, R., Mortara, A., Capomolla, S., Febo, O., Ferrari, R., Franchini, M., Gnemmi, M., Opasich, C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000047275.25795.17 · Cited by 917
Ambient Pollution and Heart Rate Variability
Gold, D. R., Litonjua, A. A., Schwartz, J. D., Lovett, E. G., Larson, A. C., Nearing, B. D., Allen, G. A., Verrier, M., Cherry, R. C., & Verrier, R. L. (2000) · Circulation · doi:10.1161/01.cir.101.11.1267 · Cited by 869

Show all 43 references

Research works printed but not linked: 7

10.1161/circ.105.9.1135 · DOI
10.1161/circ.101.11.1267 · DOI
10.1161/circ.103.23.2810 · DOI
10.1161/circ.90.3.8087947 · DOI
10.1161/circ.104.9.986 · DOI
Godleski JJ. Cardiovascular responses to inhaled particles. In: Heinrich U Mohr U eds. Relationships Between Acute and Chronic Effects of Air Pollution. Washington DC: ILSI Press; 2000: 141–155.
2001, Res Rep Health Eff Inst, 104, 5

Sorted by citations

Items 601–700 of 1,006

Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry
Neophytou, A. M., Hart, J. E., Cavallari, J. M., Smith, T. J., Dockery, D. W., Coull, B. A., Garshick, E., & Laden, F. (2013) · Environmental Health · doi:10.1186/1476-069x-12-105 · Cited by 74
Associating ambient exposure to fine particles and human fertility rates in China
Xue, T., & Zhang, Q. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.01.009 · Cited by 74
Coarse particulate matter (PM2.5–10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains
Ljubimova, J. Y., Braubach, O., Patil, R., Chiechi, A., Tang, J., Galstyan, A., Shatalova, E. S., Kleinman, M. T., Black, K. L., & Holler, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-23885-3 · Cited by 74
Outdoor Air Pollution: Sources, Atmospheric Transport, and Human Health Effects
Thurston, G. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803678-5.00320-9 · Cited by 75
Self-citation
Long-Term Exposure to Air Pollution and Incidence of Myocardial Infarction: A Danish Nurse Cohort Study
Cramer, J., Jørgensen, J. T., Hoffmann, B. H., Loft, S. H., Bräuner, E. V., Prescott, E., Ketzel, M., Hertel, O., Brandt, J. G., Jensen, S. S., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp5818 · Cited by 72
“There is growing evidence on the association between long-term exposure to air pollution and cardiovascular disease (CVD) mortality (Faustini et al. 2014; Lelieveld et al. 2019; Pope et al. 2004).”
Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis
Jiang, J., Liang, S., Zhang, J., Du, Z., Xu, Q., Duan, J., & Sun, Z. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12686 · Cited by 71
Coal dust exposure and mortality from ischemic heart disease among a cohort of U.S. coal miners
Landen, D. D., Wassell, J. T., McWilliams, L. J., & Patel, A. S. (2011) · American Journal of Industrial Medicine · doi:10.1002/ajim.20986 · Cited by 75
The effects of dust–haze on mortality are modified by seasons and individual characteristics in Guangzhou, China
Liu, T., Zhang, Y. H., Xu, Y. J., Lin, H. L., Xu, X. S., Luo, Y., Xiao, J., Zeng, W. L., Zhang, W. F., Chu, C. M.-Y., et al. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2013.12.027 · Cited by 73
Experimental investigation of soot deposition in diesel particulate filters
Bensaid, S., Marchisio, D. L., Russo, N., & Fino, D. (2009) · Catalysis Today · doi:10.1016/j.cattod.2009.07.039 · Cited by 73
Influences of Commuting Mode, Air Conditioning Mode and Meteorological Parameters on Fine Particle (PM2.5) Exposure Levels in Traffic Microenvironments
Wu, D., Lin, M., Chan, C., Li, W., Tao, J., Li, Y., Sang, X.-F., & Bu, C.-W. (2013) · Aerosol and Air Quality Research · doi:10.4209/aaqr.2012.08.0212 · Cited by 73
Indirect adjustment for multiple missing variables applicable to environmental epidemiology
Shin, H. H., Cakmak, S., Brion, O., Villeneuve, P. J., Turner, M. C., Goldberg, M. S., Jerrett, M., Chen, H., Crouse, D. L., Peters, P. A., et al. (2014) · Environmental Research · doi:10.1016/j.envres.2014.05.016 · Cited by 73
Self-citation
A cohort study of intra-urban variations in volatile organic compounds and mortality, Toronto, Canada
Villeneuve, P. J., Jerrett, M., Su, J. G., Burnett, R. T., Chen, H., Brook, J. R., Wheeler, A. J., Cakmak, S., & Goldberg, M. S. (2013) · Environmental Pollution · doi:10.1016/j.envpol.2012.12.022 · Cited by 73
Self-citation
Multi-organ toxicity induced by fine particulate matter PM 2.5 in zebrafish ( Danio rerio ) model
Duan, J., Hu, H., Zhang, Y., Feng, L., Shi, Y., Miller, M. R., & Sun, Z. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.04.013 · Cited by 73
“5 exposure (Pope et al., 2004).”
Health burdens of ambient PM2.5 pollution across Chinese cities during 2006–2015
Zhu, G., Hu, W., Liu, Y., Cao, J., Ma, Z., Deng, Y., Sabel, C. E., & Wang, H. (2019) · Journal of Environmental Management · doi:10.1016/j.jenvman.2019.04.119 · Cited by 72
Concentrated ambient fine particulate matter (PM2.5) exposure induce brain damage in pre and postnatal exposed mice
Domenico, M. D., Benevenuto, S. G. D. M., Tomasini, P. P., Yariwake, V. Y., Alves, N. D. O., Rahmeier, F. L., Fernandes, M. D. C., Moura, D. J., Saldiva, P. H. N., & Veras, M. M. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.05.004 · Cited by 75
The short-term effects of air pollutants on respiratory disease mortality in Wuhan, China: comparison of time-series and case-crossover analyses
Ren, M., Li, N., Wang, Z., Liu, Y., Chen, X., Chu, Y., Li, X., Zhu, Z., Tian, L., & Xiang, H. (2017) · Scientific Reports · doi:10.1038/srep40482 · Cited by 71
“Extensive clinical, epidemiological, and toxicological studies have provided evidence of relationships between exposure to ambient air contaminants and human health 4–11 .”
Air Pollution in the Hindu Kush Himalaya
Saikawa, E., Panday, A. K., Kang, S., Gautam, R., Zusman, E., Cong, Z., Somanathan, E., & Adhikary, B. (2019) · Springer eBooks · doi:10.1007/978-3-319-92288-1_10 · Cited by 76
The role of cardiovascular disease in the relationship between air pollution and incident dementia: a population-based cohort study
Ilango, S. D., Chen, H., Hystad, P., van Donkelaar, A., Kwong, J. C., Tu, K., Martin, R. V., & Benmarhnia, T. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz154 · Cited by 73
Assessment of pedestrian exposure and deposition of PM10, PM2.5 and ultrafine particles at an urban roadside: A case study of Xi'an, China
Lv, H., Li, H., Qiu, Z., Zhang, F., & Song, J. (2021) · Atmospheric Pollution Research · doi:10.1016/j.apr.2021.02.018 · Cited by 72
Comparisons of particulate matter, CO, and CO2 levels in underground and ground-level stations in the Taipei mass rapid transit system
Cheng, Y., & Yan, J.-W. (2011) · Atmospheric Environment · doi:10.1016/j.atmosenv.2011.06.011 · Cited by 71
Particulate air pollution induces arrhythmia via oxidative stress and calcium calmodulin kinase II activation
Kim, J., Kim, C., Choi, E., Park, S., Park, H., Pak, H., Lee, M., Shin, D.-C., Hwang, K.-C., & Joung, B. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.12.007 · Cited by 71
A Comparison of Standard Methods With G-estimation of Accelerated Failure-time Models to Address The Healthy-worker Survivor Effect
Chevrier, J., Picciotto, S., & Eisen, E. A. (2012) · Epidemiology · doi:10.1097/ede.0b013e318245fc06 · Cited by 71
An LUR/BME Framework to Estimate PM2.5 Explained by on Road Mobile and Stationary Sources
Reyes, J. M., & Serre, M. L. (2014) · Environmental Science & Technology · doi:10.1021/es4040528 · Cited by 71
Projecting Fine Particulate Matter-Related Mortality in East China
Madaniyazi, L., Nagashima, T., Guo, Y., Yu, W., & Tong, S. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01478 · Cited by 70
Urban Particulate Matter Causes ER Stress and the Unfolded Protein Response in Human Lung Cells
Watterson, T. L., Hamilton, B., Martin, R. S., & Coulombe, R. A. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp186 · Cited by 70
Traffic-Generated Air Pollution and Myocardial Infarction
Rosenlund, M., Bellander, T., Nordquist, T., & Alfredsson, L. S. (2009) · Epidemiology · doi:10.1097/ede.0b013e318190ea68 · Cited by 70
Monthly and Seasonal Variations in Aerosol Associated n-alkane Profiles in Relation to Meteorological Parameters in New Delhi, India
Yadav, S., Tandon, A., & Attri, A. K. (2013) · Aerosol and Air Quality Research · doi:10.4209/aaqr.2012.01.0004 · Cited by 70
Regional sources of airborne ultrafine particle number and mass concentrations in California
Yu, X., Venecek, M. A., Kumar, A., Hu, J., Tanrikulu, S., Soon, S.-T., Tran, C., Fairley, D., & Kleeman, M. J. (2019) · Atmospheric chemistry and physics · doi:10.5194/acp-19-14677-2019 · Cited by 73
Associations of air pollution and greenness with mortality in Greece: An ecological study
Kasdagli, M., Katsouyanni, K., de Hoogh, K., Λάγιου, Π., & Samoli, E. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110348 · Cited by 71
Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions
Long, E., & Carlsten, C. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-022-00450-5 · Cited by 79
Insights into the Atmospheric Persistence, Transformation, and Health Implications of Organophosphate Esters in Urban Ambient Air
Lao, J.-Y., Lin, H., Qin, X., Ruan, Y., Leung, K., Zeng, E. Y., & Lam, P. K. S. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c01161 · Cited by 69
Long-term exposure to traffic-related air pollution and mortality in Shizuoka, Japan
Yorifuji, T., Kashima, S., Tsuda, T., Takao, S., Suzuki, E., Doi, H., Sugiyama, M., Ishikawa‐Takata, K., & Ohta, T. (2009) · Occupational and Environmental Medicine · doi:10.1136/oem.2008.045542 · Cited by 69
Options for Occupational Health Surveillance of Workers Potentially Exposed to Engineered Nanoparticles: State of the Science
Schulte, P. A., Trout, D. B., ZUMWALDE, R. D., Kuempel, E. D., Geraci, C. L., Castranova, V., Mundt, D. J., Mundt, K. A., & Halperin, W. (2008) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e31816515f7 · Cited by 69
Differential Regulation of the Lung Endothelin System by Urban Particulate Matter and Ozone
Thomson, E. M., Kumarathasan, P., Goegan, P., Aubin, R. A., & Vincent, R. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi272 · Cited by 69
Ambient PM2.5 and O3 and their combined effects on prevalence of presbyopia among the elderly: A cross-sectional study in six low- and middle-income countries
Lin, H., Guo, Y., Ruan, Z., Yang, Y., Chen, Y., Zheng, Y., Cummings‐Vaughn, L. A., Rigdon, S. E., Vaughn, M. G., Sun, S., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.239 · Cited by 69
Greenspaces And Cardiovascular Health
Keith, R. J., Hart, J. L., & Bhatnagar, A. (2024) · Circulation Research · doi:10.1161/circresaha.124.323583 · Cited by 73
Air pollution, vascular disease and thrombosis: linking clinical data and pathogenic mechanisms
Franchini, M., Guida, A., Tufano, A., & Coppola, A. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12006 · Cited by 67
Effects of short‐term exposure to inhalable particulate matter on DNA methylation of tandem repeats
Guo, L., Byun, H., Zhong, J., Motta, V., Barupal, J. K., Zheng, Y., Chang, D., Zhang, F., McCracken, J. P., Díaz-Artiga, A., et al. (2014) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21838 · Cited by 69
Disturbance effects of PM10 on iNOS and eNOS mRNA expression levels and antioxidant activity induced by ischemia–reperfusion injury in isolated rat heart: protective role of vanillic acid
Dianat, M., Radmanesh, E., Badavi, M., Mard, S. A., & Goudarzi, G. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5759-x · Cited by 68
Examining Joint Effects of Air Pollution Exposure and Social Determinants of Health in Defining “At‐Risk” Populations Under the Clean Air Act: Susceptibility of Pregnant Women to Hypertensive Disorders of Pregnancy
Koman, P. D., Hogan, K. A., Sampson, N., Mandell, R. J., Coombe, C. M., Tetteh, M. M., Hill-Ashford, Y., Wilkins, D., Zlatnik, M. G., Loch-Caruso, R. K., et al. (2018) · World Medical & Health Policy · doi:10.1002/wmh3.257 · Cited by 70
Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease
Poulsen, S. S., Saber, A. T., Mortensen, A., Szarek, J., Wu, D., Williams, A., Andersen, O., Jacobsen, N. R., Yauk, C. L., Wallin, H., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.01.011 · Cited by 69
Particulate air pollution and coronary heart disease
Simkhovich, B. Z., Kleinman, M. T., & Kloner, R. A. (2009) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32833161e5 · Cited by 67
Air Pollution and Ischemic Stroke Among Young Adults
Yitshak‐Sade, M., Novack, V., Ifergane, G., Horev, A., & Kloog, I. (2015) · Stroke · doi:10.1161/strokeaha.115.010992 · Cited by 71
Preliminary investigation of PM1, PM2.5, PM10 and its metal elemental composition in tunnels at a subway station in Shanghai, China
Qiao, T., Xiu, G., Zheng, Y., Yang, J., Wang, L., Yang, J., & Huang, Z. (2015) · Transportation Research Part D Transport and Environment · doi:10.1016/j.trd.2015.09.013 · Cited by 67
Single particle mass spectral signatures from vehicle exhaust particles and the source apportionment of on-line PM 2.5 by single particle aerosol mass spectrometry
Yang, J., Ma, S., Gao, B., Li, X., Zhang, Y., Cai, J., Li, M., Yao, L., Huang, B., & Zheng, M. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.03.099 · Cited by 67
“Atmospheric aerosol particles are of considerable importance due to their impacts on global climate, regional air pollution, and human health (Pöschl, 2005; Dockery et al., 1993; Pope et al., 2004).”
Background
Sampling and single particle analysis for the chemical characterisation of fine atmospheric particulates: A review
Elmes, M., & Gasparon, M. (2017) · Journal of Environmental Management · doi:10.1016/j.jenvman.2017.06.067 · Cited by 67
Daytime Changes in Postural Stability and Repeatability of Posturographic Measurements
Forsman, P., Hæggström, E., Wallin, A. E., Toppila, E. M., & Pyykkö, I. V. (2007) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e3180577796 · Cited by 67
Vascular and cardiac autonomic function and PM2.5 constituents among the elderly: A longitudinal study
Lim, Y.-H., Bae, H.-J., Yi, S., Park, E.-H., Lee, B.-E., & Hong, Y. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.07.077 · Cited by 66
Towards Integrated Air Pollution Monitoring and Health Impact Assessment Using Federated Learning: A Systematic Review
Neo, E. X., Hasikin, K. B., Mokhtar, M. I., Lai, K. W., Azizan, M. M., Razak, S. A., & Hizaddin, H. F. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.851553 · Cited by 73
Nonviral Vectors for The Delivery of Small Interfering RNAs to The CNS
Posadas, I., Guerra, F. J., & Ceña, V. (2010) · Nanomedicine · doi:10.2217/nnm.10.105 · Cited by 68
Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-κB signaling
Tsou, T., Yeh, S., Tsai, F., Lin, H.-J., Cheng, T., Chao, H., & Tai, L. (2010) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2010.07.010 · Cited by 66
Evaluation of the Effects of Ozone Oxidation on Redox-Cycling Activity of Two-Stroke Engine Exhaust Particles
McWhinney, R. D., Gao, S. S., Zhou, S., & Abbatt, J. P. D. (2011) · Environmental Science & Technology · doi:10.1021/es102874d · Cited by 66
Biomarkers of the health outcomes associated with ambient particulate matter exposure
Yang, L., Hou, X., Wei, Y., Thai, P. K., & Chai, F. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.11.146 · Cited by 68
Possible Mediation by Methylation in Acute Inflammation Following Personal Exposure to Fine Particulate Air Pollution
Wang, C., Chen, R., Shi, M., Cai, J., Shi, J., Yang, C., Li, H., Lin, Z., Meng, X., Liu, C., et al. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx277 · Cited by 65
You are what you breathe: Evidence linking air pollution and blood pressure
Brook, R. D. (2005) · Current Hypertension Reports · doi:10.1007/s11906-005-0037-9 · Cited by 64
Meteorological parameters and gaseous pollutant concentrations as predictors of daily continuous PM2.5 concentrations using deep neural network in Beijing–Tianjin–Hebei, China
Wang, X., & Sun, W. (2019) · Atmospheric Environment · doi:10.1016/j.atmosenv.2019.05.004 · Cited by 66
Analyses of the Effects of Global Change on Human Health and Welfare and Human Systems
Ebi, K. L., Grambsch, A. E., Sussman, F. G., & Wilbanks, T. J. (2008) · U.S. Climate Change Science Program eBooks · Cited by 66
Air quality modeling and mortality impact of fine particles reduction policies in Spain
Boldo, E., Linares, C., Aragonés, N., Lumbreras, J., Borge, R., de la Paz, D., Pérez‐Gómez, B., Fernández‐Navarro, P., García‐Pérez, J., Pollán, M., et al. (2013) · Environmental Research · doi:10.1016/j.envres.2013.10.009 · Cited by 70
Outdoor air pollution, mortality, and hospital admissions from coronary heart disease in Sheffield, UK: a small-area level ecological study
Maheswaran, R., Haining, R., Brindley, P., Law, J., Pearson, T., Fryers, P. R., Wise, S. M., & Campbell, M. J. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi457 · Cited by 65
Study on the Association between Ambient Air Pollution and Daily Cardiovascular and Respiratory Mortality in an Urban District of Beijing
Zhang, F., Li, L., Krafft, T., Lv, J., Wang, W., & Pei, D. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8062109 · Cited by 65
Personal PM2.5 and CO exposures and heart rate variability in subjects with known ischemic heart disease in Mexico City
Riojas‐Rodríguez, H., Escamilla-Cejudo, J. A., González-Hermosillo, A., Téllez‐Rojo, M. M., Vallejo, M., Santos‐Burgoa, C., & Rojas‐Bracho, L. (2005) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/sj.jea.7500453 · Cited by 64
Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells
Harmon, A. C., Hebert, V. Y., Cormier, S. A., Balamurugan, S., Reed, J. R., Backes, W. L., & Dugas, T. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205412 · Cited by 67
Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust
Gowdy, K. M., Krantz, Q. T., DANIELS, M., Linak, W., Jaspers, I., & Gilmour, M. I. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.01.040 · Cited by 66
Poluição atmosférica e internações hospitalares por doenças respiratórias em crianças e adolescentes em Cubatão, São Paulo, Brasil, entre 1997 e 2004
Jasinski, R., Pereira, L. A. A., & Braga, A. L. F. (2011) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2011001100017 · Cited by 64
Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice
Ganguly, K., Ettehadieh, D., Upadhyay, S., Takenaka, S., Adler, T., Karg, E. W., Krombach, F., Kreyling, W. G., Schulz, H., Schmid, O., et al. (2017) · Particle and Fibre Toxicology · doi:10.1186/s12989-017-0200-x · Cited by 63
“Several hypotheses have been put forward to explain the mechanisms through which inhaled particles can interact with the cardiovascular system [8, 39].”
Background
Preventing Heart Failure: A Position Paper of the Heart Failure Association in Collaboration with the European Association of Preventive Cardiology
Piepoli, M. F., Adamo, M., Barison, A., Bestetti, R. B., Biegus, J., Böhm, M., Butler, J., Carapetis, J. R., Ceconi, C., Chioncel, O. D., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2351 · Cited by 73
Superparamagnetic iron oxide polyacrylic acid coated γ-Fe2O3 nanoparticles do not affect kidney function but cause acute effect on the cardiovascular function in healthy mice
Iversen, N., Frische, S., Thomsen, K. L., Laustsen, C., Pedersen, M., Hansen, P., Bie, P., Fresnais, J., Berret, J., Baatrup, E., et al. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.10.014 · Cited by 64
An Integrated Framework for Risk Management and Population Health
Krewski, D. R., Hogan, V., Turner, M. C., Zeman, P. L., McDowell, I., Edwards, N. C., & Losos, J. (2007) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807030701655798 · Cited by 64
Self-citation
Effect of ambient particulate matter exposure on hemostasis
Cozzi, E., Wingard, C. J., Cascio, W. E., Devlin, R. B., Miles, J. J., Bofferding, A., Lust, R. M., Scott, M. R. V., & Henriksen, R. A. (2007) · Translational research · doi:10.1016/j.trsl.2006.12.009 · Cited by 63
A systematic review of air pollution and incidence of out-of-hospital cardiac arrest
Teng, T. K., Williams, T. A., Bremner, A., Tohira, H., Franklin, P., Tonkin, A. M., Jacobs, I. G., & Finn, J. (2013) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2013-203116 · Cited by 64
Enhanced toxicity of aerosol in fog conditions in the Po Valley, Italy
Decesari, S., Sowlat, M. H., Hasheminassab, S., Sandrini, S., Gilardoni, S., Facchini, M. C., Fuzzi, S., & Sioutas, C. (2017) · Atmospheric Chemistry and Physics · doi:10.5194/acp-17-7721-2017 · Cited by 66
“…impacts associated with population exposure to airborne particulate matter (PM), including, but not limited to, respiratory and cardiovascular diseases, as well as neurodegenerative effects (Pope et al., 2002; Pope et al., 2004; Dockery and Stone, 2007; Davis et al., 2013;Gauderman et al., 2015).”
Background
Deposition modeling of ambient aerosols in human respiratory system: Health implication of fine particles penetration into pulmonary region
Rajput, P., Izhar, S., & Gupta, T. (2018) · Atmospheric Pollution Research · doi:10.1016/j.apr.2018.08.013 · Cited by 63
Fine particulate matter (PM2.5) inhalation-induced alterations in the plasma lipidome as promoters of vascular inflammation and insulin resistance
Hill, B. G., Rood, B. R., Ribble, A., & Haberzettl, P. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00881.2020 · Cited by 63
PM2.5 concentration prediction during COVID-19 lockdown over Kolkata metropolitan city, India using MLR and ANN models
Bera, B., Bhattacharjee, S., Sengupta, N., & Saha, S. (2021) · Environmental Challenges · doi:10.1016/j.envc.2021.100155 · Cited by 70
Exploring the uncertainty associated with satellite-based estimates of premature mortality due to exposure to fine particulate matter
Ford, B., & Heald, C. L. (2016) · Atmospheric chemistry and physics · doi:10.5194/acp-16-3499-2016 · Cited by 68
Vascular Effects of Ultrafine Particles in Persons with Type 2 Diabetes
Stewart, J. C., Chalupa, D., Devlin, R. B., Frasier, L. M., Huang, L., Little, E. L., Lee, S. M., Phipps, R. P., Pietropaoli, A. P., Taubman, M. B., et al. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.1002237 · Cited by 63
Acute exposure to elevated PM2.5 generated by traffic and cardiopulmonary health effects in healthy older adults
Fan, Z. T., Meng, Q., Weisel, C. P., Laumbach, R. J., Ohman‐Strickland, P., Shalat, S. L., Hernandez, M. Z., & Black, K. (2008) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2008.46 · Cited by 63
Addressing Emerging Risks: Scientific and Regulatory Challenges Associated with Environmentally Persistent Free Radicals
Dugas, T. R., Lomnicki, S. M., Cormier, S. A., Dellinger, B., & Reams, M. A. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13060573 · Cited by 63
“Moreover, epidemiological data suggest a link between PM exposures and cardiovascular events and mortality [28].”
Tackling the mortality from long-term exposure to outdoor air pollution in megacities: Lessons from the Greater Cairo case study
Wheida, A., Nasser, A., El-Nazer, M., Borbon, A., Ata, G. A. A. E., Wahab, M. A., & Alfaro, S. C. (2017) · Environmental Research · doi:10.1016/j.envres.2017.09.028 · Cited by 63
Nanoparticles in the lung and their protein corona: the few proteins that count
Whitwell, H. J., Mackay, R.-M. A., Elgy, C. N., Morgan, C., Griffiths, M., Clark, H. W., Skipp, P. J. S., & Madsen, J. (2016) · Nanotoxicology · doi:10.1080/17435390.2016.1218080 · Cited by 62
“Epidemiological studies have demonstrated a link between airborne particulate matter and increased morbidity and mortality (Laden et al., 2000, 2006; Pope et al., 2004; Samet et al., 2000).”
Background
Health Risks of Major Air Pollutants, their Drivers and Mitigation Strategies: A Review
Maji, S. K., Ahmed, S., Kaur-Sidhu, M., Mor, S., & Ravindra, K. (2023) · Air Soil and Water Research · doi:10.1177/11786221231154659 · Cited by 69
“The harmful substances can directly lead to structural damage to the cardiovascular system, including inflammation and degenerative changes, as high-lighted by Pope et al.(2004).”
Background
Magnetism of outdoor and indoor settled dust and its utilization as a tool for revealing the effect of elevated particulate air pollution on cardiovascular mortality
Jordanova, D., Jordanova, N., Lanos, P., Petrov, P., & Tsacheva, T. (2012) · Geochemistry Geophysics Geosystems · doi:10.1029/2012gc004160 · Cited by 63
Air Pollution modifies the association between successful and pathological aging throughout the frailty condition
Fougère, B., Vellas, B. J., Billet, S., Martin, P. J., Gallucci, M., & Cesari, M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.004 · Cited by 62
Spatial analysis of air pollution and cancer incidence rates in Haifa Bay, Israel
Eitan, O., Yuval, Barchana, M., Dubnov, J., Linn, S., Carmel, Y., & Broday, D. M. (2010) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2010.06.031 · Cited by 62
Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta
Ma, Y., Niu, R., Sun, Z., Wang, J., Luo, G., Zhang, J., & Wang, J. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0803-9 · Cited by 63
Assessing air quality and health benefits of the Clean Truck Program in the Alameda corridor, CA
Lee, G., You, S. I., Ritchie, S. G., Saphores, J.-D. M., Jayakrishnan, R., & Ogunseitan, O. A. (2012) · Transportation Research Part A Policy and Practice · doi:10.1016/j.tra.2012.05.005 · Cited by 62
Fine particle concentrations in buses and taxis in Florence, Italy
Fondelli, M. C., Chellini, E., Yli‐Tuomi, T., Cenni, I., Gasparrini, A., Nava, S., García-Orellana, I., Lupi, A., Grechi, D., Mallone, S., et al. (2008) · Atmospheric Environment · doi:10.1016/j.atmosenv.2008.07.054 · Cited by 62
Cause-Specific Mortality in the Unionized U.S. Trucking Industry
Laden, F., Hart, J. E., Smith, T. J., Davis, M. E., & Garshick, E. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10027 · Cited by 62
Vehicular Air Pollution, Playgrounds, and Youth Athletic Fields
Rundell, K. W., Caviston, R., Hollenbach, A. M., & Murphy, K. (2006) · Inhalation Toxicology · doi:10.1080/08958370600685640 · Cited by 62
Air pollution from fireworks during festival of lights (Deepawali) in Howrah, India - a case study
Thakur, B., Chakraborty, S., Debsarkar, A., Chakrabarty, S. N., & Srivastava, R. C. (2010) · Cited by 62
Association between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis
Akintoye, E. O., Shi, L., Obaitan, I., Olusunmade, M., Wāng, Y., Newman, J. D., & Dodson, J. A. (2015) · European Journal of Preventive Cardiology · doi:10.1177/2047487315588758 · Cited by 64
Relationships of surface ozone with its precursors, particulate matter and meteorology over Delhi
Sharma, A. K., Mandal, T. K., Sharma, S. K., Shukla, D. K., & Singh, S. (2016) · Journal of Atmospheric Chemistry · doi:10.1007/s10874-016-9351-7 · Cited by 62
Associations between fine particulate matter and changes in lipids/lipoproteins among midlife women
Wu, X., Broadwin, R., Basu, R., Malig, B. J., Ebisu, K., Gold, E. B., Qi, L., Derby, C. A., Park, S. K., & Green, S. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.149 · Cited by 63
“The strongest associations have been with morbidity and mortality from cardiovascular diseases (CVDs) (Dockery et al. 1993; Miller et al. 2007; Pope et al. 2004).”
Background
Understanding the Joint Impacts of Fine Particulate Matter Concentration and Composition on the Incidence and Mortality of Cardiovascular Disease: A Component-Adjusted Approach
Chen, H., Zhang, Z., van Donkelaar, A., Bai, L., Martin, R. V., Lavigne, É., Kwong, J. C., & Burnett, R. T. (2020) · Environmental Science & Technology · doi:10.1021/acs.est.9b06861 · Cited by 60
Self-citation
PM2.5 Concentration and Composition in Subway Systems in the Northeastern United States
Luglio, D. G., Katsigeorgis, M., Hess, J., Kim, R., Adragna, J., Raja, A., Gordon, C., Fine, J. A., Thurston, G. D., Gordon, T., et al. (2021) · Environmental Health Perspectives · doi:10.1289/ehp7202 · Cited by 61
Self-citation
Temperature, traffic-related air pollution, and heart rate variability in a panel of healthy adults
Wu, S., Deng, F., Liu, Y., Shima, M., Niu, J., Huang, Q., & Guo, X. (2012) · Environmental Research · doi:10.1016/j.envres.2012.08.008 · Cited by 61
Non‐nutrient causes of low‐grade, systemic inflammation: support for a ‘canary in the mineshaft’ view of obesity in chronic disease
Egger, G. J., & Dixon, J. B. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00795.x · Cited by 60
Circulatory disease mortality rates in the elderly and exposure to PM2.5 generated by biomass burning in the Brazilian Amazon in 2005
Nunes, K. V. R., Ignotti, E., & Hacon, S. (2013) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2013000300016 · Cited by 63
Urban pollution and solar radiation impacts
Khodakarami, J., & Ghobadi, P. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.12.166 · Cited by 63
Exposure to Particles from Laser Printers Operating within Office Workplaces
McGarry, P., Morawska, L., He, C., Jayaratne, R. E., Falk, M. G., Tran, Q., & Wang, H. (2011) · Environmental Science & Technology · doi:10.1021/es200249n · Cited by 61

Authors: Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J.
Affiliations: Brigham Young University (US)
ORCID: Pope, C. Arden
Burnett, Richard T.
Thurston, George D.
Calle, Eugenia E.
Krewski, Daniel
Godleski, John J.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-01-06
Volume: 109
Issue: 1
Pages: 71-77
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000108927.80044.7f
OpenAlex: W2096673955
Cited by: 2,592
References: 43
Citations by year: 2026: 42 · 2025: 64 · 2024: 79 · 2023: 83 · 2022: 108 · 2021: 152 · 2020: 156 · 2019: 130 · 2018: 157 · 2017: 130 · 2016: 133 · 2015: 148 · 2014: 141 · 2013: 157 · 2012: 125
FWCI: 44.60
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences (ES 08129, R01ES012972, ES00260, ES09560, P30ES000002, P30ES000260, P01ES008129, R01ES009560)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Physical Sciences › Environmental Science › Pollution › Energy and Environment Impacts
Keywords: PM2.5, air pollution, cardiovascular mortality, cause-specific mortality, ischemic heart disease, heart failure, cardiac arrest, cardiac arrhythmias, respiratory mortality, smoking, lung inflammation, atherosclerosis, cardiac autonomic function
MeSH terms: Adult, Air Pollution, Arteriosclerosis, Autonomic Nervous System, Cardiovascular Diseases, Cause of Death, Female, Heart, Humans, Inflammation, Lung Diseases, Male, Particle Size, Prospective Studies, Smoking, Time Factors, United States, Odds Ratio, Myocardial Ischemia, Pulmonary Disease, Chronic Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks