Cited by 2,592Air Quality and Health ImpactsIndoor Air Quality and Microbial ExposureEnergy and Environment Impacts

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Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease

Pope, C. Arden, Burnett, Richard T., Thurston, George D., Thun, Michael J., Calle, Eugenia E., Krewski, Daniel, Godleski, John J.·2004·Circulation

DOI 10.1161/01.cir.0000108927.80044.7f

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Abstract

Background— Epidemiologic studies have linked long-term exposure to fine particulate matter air pollution (PM) to broad cause-of-death mortality. Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality. Methods and Results— General pathophysiological pathways linking long-term PM exposure with mortality and expected patterns of PM mortality with specific causes of death were proposed a priori. Vital status, risk factor, and cause-of-death data, collected by the American Cancer Society as part of the Cancer Prevention II study, were linked with air pollution data from United States metropolitan areas. Cox Proportional Hazard regression models were used to estimate PM-mortality associations with specific causes of death. Long-term PM exposures were most strongly associated with mortality attributable to ischemic heart disease, dysrhythmias, heart failure, and cardiac arrest. For these cardiovascular causes of death, a 10-μg/m 3 elevation in fine PM was associated with 8% to 18% increases in mortality risk, with comparable or larger risks being observed for smokers relative to nonsmokers. Mortality attributable to respiratory disease had relatively weak associations. Conclusions— Fine particulate air pollution is a risk factor for cause-specific cardiovascular disease mortality via mechanisms that likely include pulmonary and systemic inflammation, accelerated atherosclerosis, and altered cardiac autonomic function. Although smoking is a much larger risk factor for cardiovascular disease mortality, exposure to fine PM imposes additional effects that seem to be at least additive to if not synergistic with smoking.

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Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
Pope III, C. A. (2002) · JAMA · doi:10.1001/jama.287.9.1132 · Cited by 8,447
Self-citation
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Self-citation
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Air pollution and health
Brunekreef, B., & Holgate, S. T. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11274-8 · Cited by 4,701
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422
Counting Processes and Survival Analysis.
Dabrowska, D. M., Fleming, T. R., & Harrington, D. P. (1992) · Journal of the American Statistical Association · doi:10.2307/2290673 · Cited by 2,287
Increased Particulate Air Pollution and the Triggering of Myocardial Infarction
Peters, A., Dockery, D. W., Muller, J. E., & Mittleman, M. A. (2001) · Circulation · doi:10.1161/01.cir.103.23.2810 · Cited by 1,479
Short-Term Heart Rate Variability Strongly Predicts Sudden Cardiac Death in Chronic Heart Failure Patients
La Rovere, M. T., Pinna, G. D., Maestri, R., Mortara, A., Capomolla, S., Febo, O., Ferrari, R., Franchini, M., Gnemmi, M., Opasich, C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000047275.25795.17 · Cited by 917
Ambient Pollution and Heart Rate Variability
Gold, D. R., Litonjua, A. A., Schwartz, J. D., Lovett, E. G., Larson, A. C., Nearing, B. D., Allen, G. A., Verrier, M., Cherry, R. C., & Verrier, R. L. (2000) · Circulation · doi:10.1161/01.cir.101.11.1267 · Cited by 869

Show all 43 references

Research works printed but not linked: 7

10.1161/circ.105.9.1135 · DOI
10.1161/circ.101.11.1267 · DOI
10.1161/circ.103.23.2810 · DOI
10.1161/circ.90.3.8087947 · DOI
10.1161/circ.104.9.986 · DOI
Godleski JJ. Cardiovascular responses to inhaled particles. In: Heinrich U Mohr U eds. Relationships Between Acute and Chronic Effects of Air Pollution. Washington DC: ILSI Press; 2000: 141–155.
2001, Res Rep Health Eff Inst, 104, 5

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Diesel exhaust particles induce endothelial dysfunction in apoE−/− mice
Hansen, C. S., Sheykhzade, M., Möller, P., Folkmann, J. K., Amtorp, O., Jonassen, T. E. N., & Loft, S. H. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.10.032 · Cited by 96
In vitro estrogenicity of ambient particulate matter: contribution of hydroxylated polycyclic aromatic hydrocarbons
Wenger, D., Gerecke, A. C., Heeb, N. V., Schmid, P., Hueglin, C., Naegeli, H., & Zenobi, R. (2008) · Journal of Applied Toxicology · doi:10.1002/jat.1400 · Cited by 96
Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance
Caraballo, J. C., Yshii, C., Westphal, W., Moninger, T. O., & Comellas, A. P. (2010) · Respirology · doi:10.1111/j.1440-1843.2010.01910.x · Cited by 96
Do new health conditions support mortality–air pollution effects?
Evans, M. F., & Smith, V. K. (2005) · Journal of Environmental Economics and Management · doi:10.1016/j.jeem.2005.04.002 · Cited by 96
Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract
Ritz, S. A., Wan, J., & Díaz-Sánchez, D. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00170.2006 · Cited by 96
Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients
Yue, W., Schneider, A. E., Stölzel, M., Rückerl, R., Cyrys, J., Pan, X., Zaręba, W., Köenig, W., Wichmann, H. ‐., & Peters, A. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.02.009 · Cited by 95
Particulate matter in the environment: pulmonary and cardiovascular effects
Alfaro‐Moreno, E., Nawrot, T. S., Nemmar, A., & Nemery, B. (2007) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328013f47e · Cited by 96
Utilizing Crowdsourced Data for Studies of Cycling and Air Pollution Exposure: A Case Study Using Strava Data
Sun, Y., & Mobasheri, A. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14030274 · Cited by 103
Are Air Pollution, Economic and Non-Economic Factors Associated with Per Capita Health Expenditures? Evidence from Emerging Economies
Usman, M. Z., Ma, Z., Zafar, M. W., Haseeb, A., & Ashraf, R. U. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16111967 · Cited by 99
“The coefficients of air pollution in the short-term, as well as in the long-term, have verified that the phenomenon of air pollution has long-term effects on public healthcare because it is the major cause of continuous environmental degradation and the main factor behind chronic diseases [44,45].”
Background
Investigating the Causal Relationships among Carbon Emissions, Economic Growth, and Life Expectancy in Turkey: Evidence from Time and Frequency Domain Causality Techniques
Rjoub, H., Odugbesan, J. A., Adebayo, T. S., & Wong, W. (2021) · Sustainability · doi:10.3390/su13052924 · Cited by 94
Pollutant constituents of exhaust emitted from light-duty diesel vehicles
Chiang, H., Lai, Y.-M., & Chang, S.-Y. (2011) · Atmospheric Environment · doi:10.1016/j.atmosenv.2011.10.045 · Cited by 94
Outdoor Air Pollution as a Trigger for Out-of-hospital Cardiac Arrests
Dennekamp, M., Akram, M., Abramson, M. J., Tonkin, A. M., Sim, M. R., Fridman, M., & Erbas, B. (2010) · Epidemiology · doi:10.1097/ede.0b013e3181e093db · Cited by 94
Pollutant Particles Produce Vasoconstriction and Enhance MAPK Signaling via Angiotensin Type I Receptor
Li, Z., Carter, J. D., Dailey, L. A., & Huang, Y.-C. T. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7736 · Cited by 94
Diesel Exhaust Inhalation and Assessment of Peripheral Blood Mononuclear Cell Gene Transcription Effects: An Exploratory Study of Healthy Human Volunteers
Peretz, A., Peck, E. C., Bammler, T. K., Beyer, R. P., Sullivan, J. H., Trenga, C. A., Srinouanprachnah, S., Farin, F. M., & Kaufman, J. D. (2007) · Inhalation Toxicology · doi:10.1080/08958370701665384 · Cited by 94
Air pollution and cardiovascular mortality with over 25years follow-up: A combined analysis of two British cohorts
Dehbi, H., Blangiardo, M., Gulliver, J., Fecht, D., de Hoogh, K., Kanaani, Z. A., Tillin, T., Hardy, R., Chaturvedi, N., & Hansell, A. (2016) · Environment International · doi:10.1016/j.envint.2016.12.004 · Cited by 94
Toxicity of lunar dust
Linnarsson, D., Carpenter, J., Fubini, B., Gerde, P., Karlsson, L. L., Loftus, D. J., Prisk, G. K., Staufer, U., Tranfield, E. M., & van Westrenen, W. (2012) · Planetary and Space Science · doi:10.1016/j.pss.2012.05.023 · Cited by 95
Can green structure reduce the mortality of cardiovascular diseases?
Shen, Y.-S., & Lung, S. C. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.05.159 · Cited by 93
Long-Term Exposure to Traffic-Related Air Pollution and Risk of Incident Atrial Fibrillation: A Cohort Study
Monrad, M., Sajadieh, A., Christensen, J. S., Ketzel, M., Raaschou‐Nielsen, O., Tjønneland, A. M., Overvad, K., Loft, S. H., & Sørensen, M. (2016) · Environmental Health Perspectives · doi:10.1289/ehp392 · Cited by 99
Urban fine particulate matter (PM2.5) exposure destroys blood–testis barrier (BTB) integrity through excessive ROS-mediated autophagy
Wei, Y., Cao, X., Tang, X., Shen, L., Lin, T., He, D., Wu, S., & Wei, G. (2017) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2017.1410743 · Cited by 93
“Particulate matter (PM) is a mixture of suspending particles from various origins, varying with locations, which has been confirmed to increase the risks of cardiopulmonary morbidity and mortality (Sarnat et al. 2001; Pope et al. 2004; Adam et al. 2015).”
Background
Associations of Long-Term Exposure to Ultrafine Particles and Nitrogen Dioxide With Increased Incidence of Congestive Heart Failure and Acute Myocardial Infarction
Bai, L., Weichenthal, S., Kwong, J. C., Burnett, R. T., Hatzopoulou, M., Jerrett, M., van Donkelaar, A., Martin, R. V., Ryswyk, K. V., Lu, H., et al. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy194 · Cited by 95
“Lastly, we indirectly adjusted for potential confounding by smoking habits and obesity, 2 major CVD risk factors (40, 41), using a recently developed method (42).”
MethodSelf-citation
Links between chronic exposure to outdoor air pollution and cardiovascular diseases: a review
Konduracka, E., & Rostoff, P. (2022) · Environmental Chemistry Letters · doi:10.1007/s10311-022-01450-9 · Cited by 100
A GIS Based Approach for Assessing the Association between Air Pollution and Asthma in New York State, USA
Gorai, A. K., Tuluri, F., & Tchounwou, P. B. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110504845 · Cited by 93
Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction
Quan, C., Sun, Q., Lippmann, M., & Chen, L. (2010) · Inhalation Toxicology · doi:10.3109/08958371003728057 · Cited by 94
Predicting Chronic Fine and Coarse Particulate Exposures Using Spatiotemporal Models for the Northeastern and Midwestern United States
Yanosky, J. D., Paciorek, C. J., & Suh, H. H. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11692 · Cited by 94
Air particulate matter SRM 1648a primes macrophages to hyperinflammatory response after LPS stimulation
Gawda, A., Majka, G., Nowak, B., Śróttek, M., Walczewska, M., & Marcinkiewicz, J. (2018) · Inflammation Research · doi:10.1007/s00011-018-1165-4 · Cited by 71
“Notably, increased incidence and exacerbation of cardiopulmonary disorders has been found to associated with elevated levels of urban particulate matter [6, 25, 26].”
Background
Role of Cyt-C/caspases-9,3, Bax/Bcl-2 and the FAS death receptor pathway in apoptosis induced by zinc oxide nanoparticles in human aortic endothelial cells and the protective effect by alpha-lipoic acid
Liang, S., Sun, K., Wang, Y., Dong, S., Wang, C., Liu, L., & Wu, Y. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.08.013 · Cited by 92
Effect of atmospheric mixing layer depth variations on urban air quality and daily mortality during Saharan dust outbreaks
Pandolfi, M., Tobı́as, A., Alástuey, A., Sunyer, J., Schwartz, J. D., Lorente, J., Pey, J., & Querol, X. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2014.07.004 · Cited by 91
Exposure to air pollution and tobacco smoking and their combined effects on depression in six low- and middle-income countries
Lin, H., Guo, Y., Kowal, P. R., Airhihenbuwa, C. O., Di, Q., Zheng, Y., Zhao, X., Vaughn, M. G., Howard, S. W., Schootman, M., et al. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.117.202325 · Cited by 93
Air Pollution and Cardiac Arrhythmias: A Comprehensive Review
Shahrbaf, M. A., Akbarzadeh, M. A., Tabary, M., & Khaheshi, I. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100649 · Cited by 91
Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: A panel study
Shields, K. N., Cavallari, J. M., Hunt, M. J. O., Lazo, M., Molina, M. J., Molina, L. T., & Holguín, F. (2013) · Environmental Health · doi:10.1186/1476-069x-12-7 · Cited by 91
The Effects of High-Pressure Injection on a Compression–Ignition, Direct Injection of Natural Gas Engine
McTaggart-Cowan, G., Jones, H. L., Rogak, S. N., Bushe, W. K., Hill, P. G., & Munshi, S. (2006) · Journal of Engineering for Gas Turbines and Power · doi:10.1115/1.2432894 · Cited by 93
Environmental Endocrine Disruption of Energy Metabolism and Cardiovascular Risk
Kirkley, A. G., & Sargis, R. M. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0494-0 · Cited by 91

Authors: Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J.
Affiliations: Brigham Young University (US)
ORCID: Pope, C. Arden
Burnett, Richard T.
Thurston, George D.
Calle, Eugenia E.
Krewski, Daniel
Godleski, John J.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-01-06
Volume: 109
Issue: 1
Pages: 71-77
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000108927.80044.7f
OpenAlex: W2096673955
Cited by: 2,592
References: 43
Citations by year: 2026: 42 · 2025: 64 · 2024: 79 · 2023: 83 · 2022: 108 · 2021: 152 · 2020: 156 · 2019: 130 · 2018: 157 · 2017: 130 · 2016: 133 · 2015: 148 · 2014: 141 · 2013: 157 · 2012: 125
FWCI: 44.60
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences (ES 08129, R01ES012972, ES00260, ES09560, P30ES000002, P30ES000260, P01ES008129, R01ES009560)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Physical Sciences › Environmental Science › Pollution › Energy and Environment Impacts
Keywords: PM2.5, air pollution, cardiovascular mortality, cause-specific mortality, ischemic heart disease, heart failure, cardiac arrest, cardiac arrhythmias, respiratory mortality, smoking, lung inflammation, atherosclerosis, cardiac autonomic function
MeSH terms: Adult, Air Pollution, Arteriosclerosis, Autonomic Nervous System, Cardiovascular Diseases, Cause of Death, Female, Heart, Humans, Inflammation, Lung Diseases, Male, Particle Size, Prospective Studies, Smoking, Time Factors, United States, Odds Ratio, Myocardial Ischemia, Pulmonary Disease, Chronic Obstructive

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Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease

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