Cited by 2,592Air Quality and Health ImpactsIndoor Air Quality and Microbial ExposureEnergy and Environment Impacts

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Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease

Pope, C. Arden, Burnett, Richard T., Thurston, George D., Thun, Michael J., Calle, Eugenia E., Krewski, Daniel, Godleski, John J.·2004·Circulation

DOI 10.1161/01.cir.0000108927.80044.7f

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Abstract

Background— Epidemiologic studies have linked long-term exposure to fine particulate matter air pollution (PM) to broad cause-of-death mortality. Associations with specific cardiopulmonary diseases might be useful in exploring potential mechanistic pathways linking exposure and mortality. Methods and Results— General pathophysiological pathways linking long-term PM exposure with mortality and expected patterns of PM mortality with specific causes of death were proposed a priori. Vital status, risk factor, and cause-of-death data, collected by the American Cancer Society as part of the Cancer Prevention II study, were linked with air pollution data from United States metropolitan areas. Cox Proportional Hazard regression models were used to estimate PM-mortality associations with specific causes of death. Long-term PM exposures were most strongly associated with mortality attributable to ischemic heart disease, dysrhythmias, heart failure, and cardiac arrest. For these cardiovascular causes of death, a 10-μg/m 3 elevation in fine PM was associated with 8% to 18% increases in mortality risk, with comparable or larger risks being observed for smokers relative to nonsmokers. Mortality attributable to respiratory disease had relatively weak associations. Conclusions— Fine particulate air pollution is a risk factor for cause-specific cardiovascular disease mortality via mechanisms that likely include pulmonary and systemic inflammation, accelerated atherosclerosis, and altered cardiac autonomic function. Although smoking is a much larger risk factor for cardiovascular disease mortality, exposure to fine PM imposes additional effects that seem to be at least additive to if not synergistic with smoking.

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Authors: Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J.
Affiliations: Brigham Young University (US)
ORCID: Pope, C. Arden
Burnett, Richard T.
Thurston, George D.
Calle, Eugenia E.
Krewski, Daniel
Godleski, John J.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-01-06
Volume: 109
Issue: 1
Pages: 71-77
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000108927.80044.7f
OpenAlex: W2096673955
Cited by: 2,592
References: 43
Citations by year: 2026: 42 · 2025: 64 · 2024: 79 · 2023: 83 · 2022: 108 · 2021: 152 · 2020: 156 · 2019: 130 · 2018: 157 · 2017: 130 · 2016: 133 · 2015: 148 · 2014: 141 · 2013: 157 · 2012: 125
FWCI: 44.60
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences (ES 08129, R01ES012972, ES00260, ES09560, P30ES000002, P30ES000260, P01ES008129, R01ES009560)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Physical Sciences › Environmental Science › Pollution › Energy and Environment Impacts
Keywords: PM2.5, air pollution, cardiovascular mortality, cause-specific mortality, ischemic heart disease, heart failure, cardiac arrest, cardiac arrhythmias, respiratory mortality, smoking, lung inflammation, atherosclerosis, cardiac autonomic function
MeSH terms: Adult, Air Pollution, Arteriosclerosis, Autonomic Nervous System, Cardiovascular Diseases, Cause of Death, Female, Heart, Humans, Inflammation, Lung Diseases, Male, Particle Size, Prospective Studies, Smoking, Time Factors, United States, Odds Ratio, Myocardial Ischemia, Pulmonary Disease, Chronic Obstructive

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Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease

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