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Cited by 260

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice

Open access
Shiomi, Tetsuya, Tsutsui, Hiroyuki, Matsusaka, Hidenori, Murakami, Kimiyo, Hayashidani, Shunji, Ikeuchi, Masaki, Wen, Jing, Kubota, Toru, Utsumi, Hideo, Takeshita, Akira·2004·Circulation
DOI 10.1161/01.cir.0000109701.77059.e9
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Abstract

Background— Oxidative stress plays an important role in the pathophysiology of heart failure. We determined whether the overexpression of glutathione peroxidase (GSHPx) could attenuate left ventricular (LV) remodeling and failure after myocardial infarction (MI). Methods and Results— We created MI in 12- to 16-week-old, male GSHPx transgenic mice (TG+MI) and nontransgenic wild-type littermates (WT+MI) by ligating the left coronary artery. GSHPx activity was increased in the hearts of TG mice, with no significant changes in other antioxidant enzymes. LV concentrations of thiobarbituric acid–reactive substances measured in TG+MI at 4 weeks were significantly lower than those in WT+MI. The survival rate during 4 weeks of MI was significantly higher in TG+MI than in WT+MI, although the infarct size was comparable. LV cavity dilatation and dysfunction were significantly attenuated in TG+MI. LV end-diastolic pressure was increased in WT+MI and reduced in TG+MI. Improvement of LV function in TG+MI was accompanied by a decrease in myocyte hypertrophy, apoptosis, and interstitial fibrosis in the noninfarcted LV. Myocardial matrix metalloproteinase-9 zymographic and protein levels were increased in WT+MI after 3 days but were attenuated in TG+MI. Conclusions— Overexpression of GSHPx inhibited LV remodeling and failure after MI. Therapies designed to interfere with oxidative stress might be beneficial to prevent cardiac failure.

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Metadata

Authors
Shiomi, T., Tsutsui, H., Matsusaka, H., Murakami, K., Hayashidani, S., Ikeuchi, M., Wen, J., Kubota, T., Utsumi, H., & Takeshita, A.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-02-03
Volume
109
Issue
4
Pages
544-549
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000109701.77059.e9
OpenAlex
W2030929060
Cited by
260
References
26
FWCI
10.53
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice. https://app.cochat.ai/papers/10.1161/01.cir.0000109701.77059.e9
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Shiomi, T., Tsutsui, H., Matsusaka, H., Murakami, K., Hayashidani, S., Ikeuchi, M., Wen, J., Kubota, T., Utsumi, H., & Takeshita, A. (2004). Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice. Circulation. https://doi.org/10.1161/01.cir.0000109701.77059.e9

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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