Cited by 853Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionAtherosclerosis and Cardiovascular Diseases

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Endothelial Function: A Critical Determinant in Atherosclerosis?

Landmesser, Ulf, Hornig, Burkhard, Drexler, Helmut·2004·Circulation

DOI 10.1161/01.cir.0000129501.88485.1f

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Abstract

Common conditions predisposing to atherosclerosis, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with endothelial dysfunction. Endothelial function has largely been assessed as endothelium-dependent vasomotion, at least in part based on the assumption that impaired endothelium-dependent vasodilation also reflects the alteration of other important functions of the endothelium. An important rationale for this approach has been the observation that endothelium-derived nitric oxide (NO), a major mediator of endothelium-dependent vasodilation, has important anti-inflammatory and antithrombotic properties, ie, inhibiting leukocyte adhesion, limiting platelet adhesion and aggregation, and the expression of plasminogen activator inhibitor-1 (PAI-1), a prothrombotic protein. Accumulating data suggest that the degree of impairment of endothelium-dependent vasomotion has profound and independent prognostic implications. A common mechanism underlying endothelial dysfunction relates to increased vascular production of reactive oxygen species. Recent studies also suggest that inflammation per se and C-reactive protein in particular may directly contribute to endothelial dysfunction. These findings raise the question of whether assessment of endothelial function can be used in the clinical setting to identify patients at high risk. New insights into mechanisms of endothelial dysfunction, such as a better understanding of the regulation of important vascular sources of oxygen radicals, may lead to novel therapeutic strategies with the potential to improve prognosis.

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Authors: Landmesser, U., Hornig, B., & Drexler, H.
Affiliations: Medizinische Hochschule Hannover (DE)
ORCID: Landmesser, Ulf
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-06
Volume: 109
Issue: 21_suppl_1
Pages: II27-33
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000129501.88485.1f
OpenAlex: W2163221788
Cited by: 851
References: 78
Citations by year: 2026: 10 · 2025: 10 · 2024: 10 · 2023: 16 · 2022: 11 · 2021: 29 · 2020: 27 · 2019: 20 · 2018: 38 · 2017: 42 · 2016: 47 · 2015: 44 · 2014: 47 · 2013: 59 · 2012: 42
FWCI: 35.77
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: endothelial dysfunction, endothelial function, atherosclerosis, endothelium-dependent vasodilation, nitric oxide, reactive oxygen species, inflammation, C-reactive protein, plasminogen activator inhibitor-1, hypertension, hypercholesterolemia, diabetes mellitus, smoking, cardiovascular risk prediction
MeSH terms: Animals, Arteriosclerosis, Endothelium, Vascular, Humans, Inflammation, Models, Cardiovascular, Nitric Oxide, Prognosis, Thrombosis, Reactive Oxygen Species, Mice

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Endothelial Function: A Critical Determinant in Atherosclerosis?

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