Drexler, Helmut

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Lüscher, T. F., Bart, B., Banasiak, W., Niegowska, J., et al. (2009) · New England Journal of Medicine

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 2,083

Role of oxidative stress in atherosclerosis

Harrison, D., Griendling, K. K., Landmesser, U., Hornig, B., & Drexler, H. (2003) · The American Journal of Cardiology

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 1,275

Targeted Anticytokine Therapy in Patients With Chronic Heart Failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)

Mann, D. L., McMurray, J. J. V., Packer, M., Swedberg, K., Borer, J. S., Colucci, W. S., Djian, J., Drexler, H., Feldman, A., Kober, L., et al. (2004) · Circulation

Heart Failure Treatment and ManagementCardiac Fibrosis and Remodeling

Cited by 1,240

Endothelial Function: A Critical Determinant in Atherosclerosis?

Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 851

The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury

Kempf, T., Eden, M., Strelau, J., Naguib, M., Willenbockel, C., Tongers, J., Heineke, J., Kotlarz, D., Xu, J., Molkentin, J. D., et al. (2006) · Circulation Research

GDF15 and Related BiomarkersCardiac Ischemia and Reperfusion

Cited by 651

Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial

Konstam, M. A., Neaton, J. D., Dickstein, K., Drexler, H., Komajda, M., Martinez, F. A., Riegger, G. A., Malbecq, W., Smith, R. D., Guptha, S., et al. (2009) · The Lancet

Heart Failure Treatment and ManagementHeart rate and cardiovascular health

Cited by 646

Endothelial Dysfunction in Human Disease

Drexler, H., & Hornig, B. (1999) · Journal of Molecular and Cellular Cardiology

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 471

Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy

Sorrentino, S. A., Besler, C., Rohrer, L., Meyer, M., Heinrich, K., Bahlmann, F. H., Mueller, M., Horváth, T., Doerries, C., Heinemann, M., et al. (2010) · Circulation

Nitric Oxide and Endothelin EffectsLipoproteins and Cardiovascular Health

Cited by 402

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury

Hilfiker-Kleiner, D., Hilfiker, A., Fuchs, M., Kaminski, K., Schaefer, A., Schieffer, B., Hillmer, A., Schmiedl, A., Ding, Z., Podewski, E., et al. (2004) · Circulation Research

Cardiac Fibrosis and RemodelingCytokine Signaling Pathways and Interactions

Cited by 385

Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease

Schieffer, B., Bünte, C., Witte, J., Hoeper, K., Böger, R. H., Schwedhelm, E., & Drexler, H. (2004) · Journal of the American College of Cardiology

Renin-Angiotensin System StudiesEicosanoids and Hypertension Pharmacology

Cited by 239

Angiotensin II Induces Endothelial Xanthine Oxidase Activation: Role for Endothelial Dysfunction in Patients With Coronary Disease

Landmesser, U., Spiekermann, S., Preuss, C., Sorrentino, S., Fischer, D., Manes, C., Mueller, M., & Drexler, H. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology

Nitric Oxide and Endothelin EffectsGout, Hyperuricemia, Uric Acid

Cited by 210

Critical Role of the NAD(P)H Oxidase Subunit p47 phox for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction

Doerries, C., Grote, K., Hilfiker-Kleiner, D., Luchtefeld, M., Schaefer, A., Holland, S. M., Sorrentino, S., Manes, C., Schieffer, B., Drexler, H., et al. (2007) · Circulation Research

Cardiac Fibrosis and RemodelingNitric Oxide and Endothelin Effects

Cited by 206

Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction

Hilfiker-Kleiner, D., Shukla, P., Klein, G., Schaefer, A., Stapel, B., Hoch, M., Müller, W., Scherr, M., Theilmeier, G., Ernst, M., et al. (2010) · Circulation

Cardiac Fibrosis and RemodelingCytokine Signaling Pathways and Interactions

Cited by 167

Molecular Mechanisms in Heart Failure

Hilfiker-Kleiner, D., Landmesser, U., & Drexler, H. (2006) · Journal of the American College of Cardiology

Cardiac Fibrosis and RemodelingHeart Failure Treatment and Management

Cited by 151

The clinical significance of endothelial dysfunction

Landmesser, U., & Drexler, H. (2005) · Current Opinion in Cardiology

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 142

The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration

Grote, K., Salguero, G., Ballmaier, M., Dangers, M., Drexler, H., & Schieffer, B. (2007) · Blood

Connective Tissue Growth Factor ResearchAngiogenesis and VEGF in Cancer

Cited by 117

Many good reasons to have STAT3 in the heart

Hilfiker-Kleiner, D., Hilfiker, A., & Drexler, H. (2005) · Pharmacology & Therapeutics

Cytokine Signaling Pathways and InteractionsCardiac Fibrosis and Remodeling

Cited by 115

Expression of CYR61, an Angiogenic Immediate Early Gene, in Arteriosclerosis and Its Regulation by Angiotensin II

Hilfiker, A., Hilfiker-Kleiner, D., Fuchs, M., Kaminski, K., Lichtenberg, A., Rothkötter, H.-J., Schieffer, B., & Drexler, H. (2002) · Circulation

Renin-Angiotensin System StudiesCardiovascular, Neuropeptides, and Oxidative Stress Research

Cited by 114

Regulation of Proangiogenic Factor CCN1 in Cardiac Muscle: Impact of Ischemia, Pressure Overload, and Neurohumoral Activation

Hilfiker-Kleiner, D., Kaminski, K., Kaminska, A., Fuchs, M., Klein, G., Podewski, E., Grote, K., Kiian, I., Wollert, K. C., Hilfiker, A., et al. (2004) · Circulation

Connective Tissue Growth Factor ResearchCardiac Fibrosis and Remodeling

Cited by 110

Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man

Luchtefeld, M., Schunkert, H., Stoll, M., Selle, T., Lorier, R., Grote, K., Sagebiel, C., Jagavelu, K., Tietge, U. J. F., Assmus, U., et al. (2007) · The Journal of Experimental Medicine

Atherosclerosis and Cardiovascular DiseasesCytokine Signaling Pathways and Interactions

Cited by 69

Stretch-inducible Expression of the Angiogenic Factor CCN1 in Vascular Smooth Muscle Cells Is Mediated by Egr-1

Grote, K., Bavendiek, U., Grothusen, C., Flach, I., Hilfiker-Kleiner, D., Drexler, H., & Schieffer, B. (2004) · Journal of Biological Chemistry

Connective Tissue Growth Factor ResearchCardiovascular, Neuropeptides, and Oxidative Stress Research

Cited by 52