The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure
Abstract
Background— The effects of cardiac resynchronization therapy (CRT) in patients with mildly symptomatic heart failure have not been fully elucidated. Methods and Results— The Multicenter InSync ICD Randomized Clinical Evaluation II (MIRACLE ICD II) was a randomized, double-blind, parallel-controlled clinical trial of CRT in NYHA class II heart failure patients on optimal medical therapy with a left ventricular (LV) ejection fraction ≤35%, a QRS ≥130 ms, and a class I indication for an ICD. One hundred eighty-six patients were randomized: 101 to the control group (ICD activated, CRT off) and 85 to the CRT group (ICD activated, CRT on). End points included peak V̇ o 2 , V̇ e /V̇ co 2 , NYHA class, quality of life, 6-minute walk distance, LV volumes and ejection fraction, and composite clinical response. Compared with the control group at 6 months, no significant improvement was noted in peak V̇ o 2 , yet there were significant improvements in ventricular remodeling indexes, specifically LV diastolic and systolic volumes ( P =0.04 and P =0.01, respectively), and LV ejection fraction ( P =0.02). CRT patients showed statistically significant improvement in V̇ e /V̇ co 2 ( P =0.01), NYHA class ( P =0.05), and clinical composite response ( P =0.01). No significant differences were noted in 6-minute walk distance or quality of life scores. Conclusions— In patients with mild heart failure symptoms on optimal medical therapy with a wide QRS complex and an ICD indication, CRT did not alter exercise capacity but did result in significant improvement in cardiac structure and function and composite clinical response over 6 months.
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Cites
Bristow, M. R., Saxon, L. A., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., DeMets, D., White, B. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032423 · Cited by 5,812
Cardiac Resynchronization in Chronic Heart Failure
Abraham, W. T., Fisher, W. G., Smith, A. L., Delurgio, D. B., Leon, A. R., Loh, E., Kocovic, D. Z., Packer, M., Clavell, A. L., Hayes, D. L., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013168 · Cited by 4,648
Self-citationCARDIAC RESYNCHRONIZATION IN CHRONIC HEART FAILURE
Braham, W. I. T. A., Isher, W. E. G. F., Mith, L. S., Elurgio, D. A. B. D., Eon, A. N. R. L., Oh, E., Ocovic, D. U. Z. K., Acker, M. G., Lavell, L. C., Ayes, D. A. L. H., et al. (2002) · Cited by 3,808
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Young, J. B., Abraham, W. T., & Smith, A. L. (2003) · ACC Current Journal Review · doi:10.1016/j.accreview.2003.08.087 · Cited by 1,682
Self-citationSt John Sutton, M. G., Plappert, T., Abraham, W. T., Smith, A. L., DeLurgio, D. B., Leon, A. R., Loh, E., Kocovic, D. Z., Fisher, W. G., Ellestad, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000065226.24159.e9 · Cited by 1,124
Self-citationAuricchio, A., Stellbrink, C., Sack, S., Block, M., Vogt, J. Ü., Bakker, P., Huth, C., Schöndube, F., Wolfhard, U., Böcker, D., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01895-8 · Cited by 1,026
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2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8776 · Cited by 2,106
2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab364 · Cited by 2,019
2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2022) · EP Europace · doi:10.1093/europace/euab232 · Cited by 914
Tracy, C. M., Epstein, A. E., Darbar, D., DiMarco, J. P., Dunbar, S. B., Estes, N. A. M., Ferguson, T. B., Hammill, S. C., Karasik, P. E., Link, M. S., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.007 · Cited by 732
Metadata
- Authors
- Abraham, W. T., Young, J. B., León, A. R., Adler, S., Bank, A. J., Hall, S. A., Lieberman, R., Liem, L. B., O’Connell, J. B., Schroeder, J. S., & Wheelan, K. R.
- Venue
- Circulation
- Published
- 2004-11-02
- Volume
- 110
- Issue
- 18
- Pages
- 2864-2868
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2110628407
- Cited by
- 559
- References
- 17
- FWCI
- 22.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure. https://app.cochat.ai/papers/10.1161/01.cir.0000146336.92331.d1
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- Abraham, W. T., Young, J. B., León, A. R., Adler, S., Bank, A. J., Hall, S. A., Lieberman, R., Liem, L. B., O’Connell, J. B., Schroeder, J. S., & Wheelan, K. R. (2004). Effects of Cardiac Resynchronization on Disease Progression in Patients With Left Ventricular Systolic Dysfunction, an Indication for an Implantable Cardioverter-Defibrillator, and Mildly Symptomatic Chronic Heart Failure. Circulation. https://doi.org/10.1161/01.cir.0000146336.92331.d1
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