The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Heterozygosity for a Hereditary Hemochromatosis Gene Is Associated With Cardiovascular Death in Women
Open accessAbstract
Background —The genetic background of hereditary hemochromatosis ( HH ) is homozygosity for a cysteine-to-tyrosine transition at position 282 in the HFE gene. Heterozygosity for HH is associated with moderately increased iron levels and could be a risk factor for cardiovascular death. Methods and Results —We studied the relation between HH heterozygosity and cardiovascular death in a cohort study among 12 239 women 51 to 69 years of age residing in Utrecht, the Netherlands. Women were followed for 16 to 18 years (182 976 follow-up years). The allele prevalence of the HH gene in the reference group was 4.0 (95% CI 2.9 to 5.4). The mortality rate ratios for HH heterozygotes compared with wild types was 1.5 (95% CI 0.9 to 2.5) for myocardial infarction (n=242), 2.4 (95% CI 1.3 to 3.5) for cerebrovascular disease (n=118), and 1.6 (95% CI 1.1 to 2.4) for total cardiovascular disease (n=530). The population-attributable risks of HH heterozygosity for myocardial infarction and cerebrovascular and total cardiovascular death were 3.3%, 8.8%, and 4.0%, respectively. In addition, we found evidence for effect modification by hypertension and smoking. Conclusions —We found important evidence that inherited variation in iron metabolism is involved in cardiovascular death in postmenopausal women, especially in women already carrying classic risk factors.
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Cites
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.803 · Cited by 1,284
IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK
Sullivan, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92463-6 · Cited by 969
Gutteridge, J. M. C. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80626-3 · Cited by 629
Cited by
Whitfield, J. B. (2001) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/20014091084227 · Cited by 1,153
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
Fang, X., Ardehali, H., Min, J., & Wang, F. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00735-4 · Cited by 1,081
Bioavailability of iron, zinc, and other trace minerals from vegetarian diets
Hunt, J. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.633s · Cited by 637
Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
Altamura, S., & Muckenthaler, M. U. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1010 · Cited by 369
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium
Ganesh, S. K., Zakai, N. A., van Rooij, F. J. A., Soranzo, N., Smith, A. V., Nalls, M. A., Chen, M.-H., Kottgen, A., Glazer, N. L., Dehghan, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.466 · Cited by 358
Metadata
- Authors
- Roest, M., van der Schouw, Y. T., de Valk, B., Marx, J. J. M., Tempelman, M. J., de Groot, P. G., Sixma, J. J., & Banga, J. D.
- Venue
- Circulation
- Published
- 1999-09-21
- Volume
- 100
- Issue
- 12
- Pages
- 1268-1273
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2132865281
- Cited by
- 245
- References
- 4
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Roest, M., van der Schouw, Y. T., de Valk, B., Marx, J. J. M., Tempelman, M. J., de Groot, P. G., Sixma, J. J., & Banga, J. D. (1999). Heterozygosity for a Hereditary Hemochromatosis Gene Is Associated With Cardiovascular Death in Women. Circulation. https://doi.org/10.1161/01.cir.100.12.1268
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
