The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation: A Prospective Cohort Study in Men in Eastern Finland
Abstract
Background —Homozygosity for a relatively common Cys282Tyr mutation of the human hemochromatosis-associated ( HFE ) gene was recently found to account for most cases of hereditary hemochromatosis. Because excess iron has been postulated to enhance risk of vascular disease, we studied whether occurrence of this mutation was associated with increased risk of first acute myocardial infarction in healthy middle-aged men in a prospective cohort study. Methods and Results —Study subjects were the 1150 participants in the population-based Kuopio Ischemic Heart Disease Risk Factor Study (KIHD), aged 42, 48, 54, or 60 years at baseline, who had no coronary heart disease at baseline and for whom a DNA sample was available. Information about myocardial infarctions was collected prospectively by use of FINMONICA (FINnish MONItoring of trends and determinants in CArdiovascular disease study) and hospital data. Events were classified by MONICA (MONItoring of trends and determinants in CArdiovascular disease study) diagnostic criteria. The HFE Cys282Tyr mutation was assayed by a solid-phase minisequencing technique. One subject was homozygous and 76 individuals were heterozygous for the HFE Cys282Tyr mutation (6.7%). During a mean follow-up of 9 years, 8 (10.4%) of 77 carriers and 60 (5.6%) of 1073 noncarriers experienced an acute myocardial infarction. In a Cox proportional hazards model allowing for the other strongest risk factors, the carriers had a 2.3-fold (95% CI 1.1 to 4.8; P =0.03) risk of acute myocardial infarction compared with noncarriers. Conclusions —Male carriers of the common hemochromatosis gene mutation are at 2-fold risk for first acute myocardial infarction compared with noncarriers.
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Cites
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.803 · Cited by 1,284
Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebrón, J. A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., & Schatzman, R. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1472 · Cited by 827
Salonen, J. T., Seppänen, K., Nyyssönen, K., Korpela, H., Kauhanen, J., Kantola, M., Tuomilehto, J., Esterbauer, H., Tatzber, F., & Salonen, R. (1995) · Circulation · doi:10.1161/01.cir.91.3.645 · Cited by 578
Self-citationFeder, J. N., Tsuchihashi, Z., Irrinki, A., Lee, V. K., Mapa, F. A., Morikang, E., Prass, C. E., Starnes, S. M., Wolff, R. K., Parkkila, S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14025 · Cited by 471
Smith, C., Mitchinson, M. J., Aruoma, O. I., & Halliwell, B. (1992) · Biochemical Journal · doi:10.1042/bj2860901 · Cited by 455
Association Between Body Iron Stores and the Risk of Acute Myocardial Infarction in Men
Tuomainen, T.-P., Punnonen, K., Nyyssönen, K., & Salonen, J. T. (1998) · Circulation · doi:10.1161/01.cir.97.15.1461 · Cited by 286
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Cited by
Bioavailability of iron, zinc, and other trace minerals from vegetarian diets
Hunt, J. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.633s · Cited by 637
Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis
Altamura, S., & Muckenthaler, M. U. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1010 · Cited by 369
Association of age, sex, and race with body iron stores in adults: Analysis of NHANES III data
Zacharski, L. R., Ornstein, D. L., Woloshin, S., & Schwartz, L. M. (2000) · American Heart Journal · doi:10.1067/mhj.2000.106646 · Cited by 349
Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis
Day, S. M., Duquaine, D., Mundada, L. V., Menon, R. G., Khan, B. V., Rajagopalan, S., & Fay, W. P. (2003) · Circulation · doi:10.1161/01.cir.0000066910.02844.d0 · Cited by 192
Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo
Rooyakkers, T. M., Stroes, E. S. G., Kooistra, M. P., Van Faassen, E. E., Hider, R. C., Rabelink, T. J., & Marx, J. J. M. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.0320s1009.x · Cited by 157
Metadata
- Authors
- Tuomainen, T.-P., Kontula, K., Nyyssönen, K., Lakka, T. A., Heliö, T., & Salonen, J. T.
- Venue
- Circulation
- Published
- 1999-09-21
- Volume
- 100
- Issue
- 12
- Pages
- 1274-1279
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1977960047
- Cited by
- 232
- References
- 7
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation: A Prospective Cohort Study in Men in Eastern Finland. https://app.cochat.ai/papers/10.1161/01.cir.100.12.1274
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- Tuomainen, T.-P., Kontula, K., Nyyssönen, K., Lakka, T. A., Heliö, T., & Salonen, J. T. (1999). Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation: A Prospective Cohort Study in Men in Eastern Finland. Circulation. https://doi.org/10.1161/01.cir.100.12.1274
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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