Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

Smith, C; Mitchinson, M J; Aruoma, O I; Halliwell, B

doi:10.1042/bj2860901

Cited by 455Antioxidant Activity and Oxidative StressAtherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin Effects

Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

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Smith, C, Mitchinson, M J, Aruoma, O I, Halliwell, B·1992·Biochemical Journal

DOI 10.1042/bj2860901PMC PMC1132988

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Abstract

Lipid peroxidation within human arterial lesions is thought to play an important role in the development of atherosclerosis. Peroxidation can be accelerated by the presence of ‘catalytic’ iron or copper ions. Gruel samples from advanced atherosclerotic lesions in the abdominal aortae of human cadavers were tested for pro-oxidant properties. All samples contained bleomycin-detectable iron and phenanthroline-detectable copper. Almost all gruel samples stimulated peroxidation of rat liver microsomes, and this was usually inhibited by the iron-ion chelator desferrioxamine. Some samples stimulated formation of hydroxyl radicals from H2O2 in the presence of ascorbate, a reaction again inhibited by desferrioxamine. We conclude that the interior of human advanced atherosclerotic lesions is a highly pro-oxidant environment, and that the use of copper or iron ions to promote peroxidation of low-density lipoproteins in vitro may be a valid model for events in the arterial wall.

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Iron and oxidised lipids are both found in atherosclerotic lesions.
“Iron and oxidised lipids are both found in atherosclerotic lesions [141,765-777]”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [765]
Both iron and oxidised lipids are found in atherosclerotic lesions.
“Both iron and oxidised lipids (de Valk and Marx 1999; Smith et al. 1992) are found in atherosclerotic lesions”
From Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples (2010) · cites this paper as Smith et al. 1992

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Authors: Smith, C., Mitchinson, M. J., Aruoma, O. I., & Halliwell, B.
Affiliations: King's College London (GB)
University of Cambridge (GB)
ORCID: Aruoma, O I
Halliwell, B
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1992-09-15
Volume: 286
Issue: 3
Pages: 901-905
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj2860901
PMC: PMC1132988
OpenAlex: W1516636175
Cited by: 455
References: 40
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 7
FWCI: 17.32
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: lipid peroxidation, hydroxyl radicals, atherosclerosis, atherosclerotic plaque, iron, copper, pro-oxidant activity, deferoxamine, LDL oxidation, vitamin C, hydrogen peroxide, abdominal aorta, rat liver microsomes
MeSH terms: Animals, Arteriosclerosis, Cations, Copper, Deferoxamine, Humans, Hydrogen Peroxide, Hydroxides, Iron, Microsomes, Liver, Spectrophotometry, Atomic, Lipid Peroxidation, Hydroxyl Radical, Rats

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Stimulation of lipid peroxidation and hydroxyl-radical generation by the contents of human atherosclerotic lesions

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