The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Limb Blood Flow and Vascular Conductance Are Reduced With Age in Healthy Humans: Relation to Elevations in Sympathetic Nerve Activity and Declines in Oxygen Demand
Abstract
Background —We tested the hypothesis that basal (resting) limb blood flow and vascular conductance are reduced with age in adult humans and that these changes are related to elevations in sympathetic vasoconstrictor nerve activity and reductions in limb oxygen demand. Methods and Results —Sixteen young (28±1 years; mean±SEM) and 15 older (63±1 years) healthy normotensive adult men were studied. Diastolic blood pressure and body fat were higher ( P <0.005) in the older men, but there were no other age-related differences in subject characteristics. Femoral artery blood flow (Doppler ultrasound) was 26% lower in the older men ( P <0.005), despite similar levels of cardiac output (systemic arterial blood flow) in the 2 groups. Femoral artery vascular conductance was 32% lower and femoral vascular resistance was 45% higher in the older men ( P <0.005). Muscle sympathetic nerve activity (peroneal microneurography) was 74% higher in the older men ( P <0.001) and correlated with femoral artery blood flow ( r =−0.55, P <0.005), vascular conductance ( r =−0.65, P <0.001), and vascular resistance ( r =0.61, P <0.001). The age-related differences in femoral hemodynamics were no longer significant after correction for the influence of muscle sympathetic nerve activity. There were no significant age-group differences in leg tissue mass (by dual-energy x-ray absorptiometry), but estimated leg oxygen consumption was 15% lower in the older men ( P <0.001). Femoral artery blood flow was directly related to estimated leg oxygen consumption ( r =0.78, P <0.001). The age-group differences in femoral artery blood flow were no longer significant after correction for estimated leg oxygen consumption by ANCOVA. Conclusions —(1) Basal whole-leg arterial blood flow and vascular conductance are reduced with age in healthy adult men; (2) these changes are associated with elevations in sympathetic vasoconstrictor nerve activity; and (3) the lower whole-limb blood flow is related to a lower oxygen demand that is independent of tissue mass.
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Citations
Cites
Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women
Fleg, J. L., O'Connor, F., Gerstenblith, G., Becker, L. C., Clulow, J., Schulman, S. P., & Lakatta, E. G. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.890 · Cited by 506
Cited by
Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.057042 · Cited by 341
Self-citationSheffield-Moore, M., Yeckel, C. W., Volpi, E., Wolf, S. E., Morio, B., Chinkes, D. L., Paddon-Jones, D., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00334.2003 · Cited by 197
Pulse wave velocity is associated with muscle mass decline: Health ABC study
study, F. T. H. A., Abbatecola, A. M., Chiodini, P., Gallo, C., Lakatta, E., Sutton-Tyrrell, K., Tylavsky, F. A., Goodpaster, B., de Rekeneire, N., Schwartz, A. V., et al. (2012) · AGE · doi:10.1007/s11357-011-9238-0 · Cited by 114
Regulation of skeletal muscle blood flow during exercise in ageing humans
Hearon, C. M., & Dinenno, F. A. (2016) · The Journal of Physiology · doi:10.1113/jp270593 · Cited by 107
Self-citationEndothelin-A -Mediated Vasoconstriction During Exercise With Advancing Age
Barrett-O’Keefe, Z., Ives, S. J., Trinity, J. D., Morgan, G., Rossman, M. J., Donato, A. J., Runnels, S., Morgan, D. E., Gmelch, B. S., Bledsoe, A. D., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu065 · Cited by 43
Metadata
- Authors
- Dinenno, F. A., Jones, P. P., Seals, D. R., & Tanaka, H.
- Venue
- Circulation
- Published
- 1999-07-13
- Volume
- 100
- Issue
- 2
- Pages
- 164-170
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2073538254
- Cited by
- 309
- References
- 1
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- closed
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