Effect of acute and chronic ascorbic acid on flow‐mediated dilatation with sedentary and physically active human ageing

Eskurza, Iratxe; Monahan, Kevin D.; Robinson, Jed A.; Seals, Douglas R.

doi:10.1113/jphysiol.2003.057042

Cited by 341Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsCardiovascular and exercise physiology

Effect of acute and chronic ascorbic acid on flow‐mediated dilatation with sedentary and physically active human ageing

Eskurza, Iratxe, Monahan, Kevin D., Robinson, Jed A., Seals, Douglas R.·2004·The Journal of Physiology

DOI 10.1113/jphysiol.2003.057042

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Abstract

Peripheral conduit artery flow‐mediated dilatation decreases with ageing in humans. The underlying mechanisms and efficacy of preventive strategies are unknown. Brachial artery flow‐mediated dilatation was determined at baseline and after ascorbic acid (vitamin C) intravenous infusion and chronic supplementation (500 mg day −1 for 30 days) in three groups of healthy men: young sedentary ( n = 11; 25 ± 1 years, mean ± s.e.m. ), older sedentary ( n = 9; 64 ± 2), and older endurance‐exercise trained ( n = 9; 64 ± 2). At baseline, flow‐mediated dilatation (normalized for the hyperaemic stimulus) was ∼45% lower in the older (0.015 ± 0.001) versus young (0.028 ± 0.004) sedentary men ( P < 0.01), but was preserved in older exercising men (0.028 ± 0.004). Ascorbic acid infusion increased plasma concentrations > 15‐fold in all groups and restored flow‐mediated dilatation in the sedentary older men (to 0.023 ± 0.002; P > 0.1 versus other groups), with no effects in the other two groups. Oral ascorbic acid supplementation did not affect flow‐mediated dilatation in any group. Brachial artery endothelium‐independent dilatation (sublingual nitroglycerin) did not differ among the groups at baseline nor change with ascorbic acid administration. These results provide the first evidence for an important role of oxidative stress in both the impairment in peripheral conduit artery flow‐mediated dilatation with sedentary human ageing and the preservation of flow‐mediated dilatation with physically active ageing.

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Long-term exercise-trained men aged 50-76 do not show age impairment; they have similar endothelium-dependent dilation to acetylcholine-mediated vasodilation as healthy 22-35-year-old men.
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From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [167]
If endothelial dysfunction is an early marker for atherosclerosis, prevention of endothelial dysfunction by a lifetime of physical activity would prevent most atherosclerosis reaching a clinical level at age 50-76 in men or even initiation of aerobic physical activity within lifestyle.
“then a prevention of endothelial dysfunction by a lifetime of physical activity would therefore also prevent most of atherosclerosis reaching a clinical level at the age of 50–76 yrs in men (132, 167) or even initiation of aerobic physical activity within lifestyle (132).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [167]
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From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [281]
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Peripheral Circulation
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Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress
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Exercise prevents age‐related decline in nitric‐oxide‐mediated vasodilator function in cutaneous microvessels
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Impaired flow-mediated dilation with age is not explained by l -arginine bioavailability or endothelial asymmetric dimethylarginine protein expression
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IL-1 Inhibition and Vascular Function in CKD
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Strong Relationship Between Vascular Function in the Coronary and Brachial Arteries
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Cardiovascular Adaptations to Exercise Training
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B6D2F1 Mice Are a Suitable Model of Oxidative Stress-Mediated Impaired Endothelium-Dependent Dilation With Aging
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High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men
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Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles
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Modulatory influences on ageing of the vasculature in healthy humans
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Brachial artery flow-mediated dilation during handgrip exercise: evidence for endothelial transduction of the mean shear stimulus
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Nutrition and other lifestyle influences on arterial aging
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Modulatory influence of sex hormones on vascular aging
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Dose-dependent increases in flow-mediated dilation following acute cocoa ingestion in healthy older adults
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Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults
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Healthy lifestyle-based approaches for successful vascular aging
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High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men
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Endothelium‐dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration
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Ascorbic acid increases muscle blood flow during dynamic exercise in older healthy humans
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Oxidative stress contributes to the age related decline in basal leg blood flow in sedentary men
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Ascorbic acid does not influence skeletal muscle contraction‐induced rapid vasodilation in older healthy humans
Simpson, C. B., Kirby, B. S., Carlson, R. E., Schrage, W. G., Voyles, W. F., & Dinenno, F. A. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.957.3

Authors: Eskurza, I., Monahan, K. D., Robinson, J. A., & Seals, D. R.
Affiliations: University of Colorado Boulder (US)
ORCID: Monahan, Kevin D.
Seals, Douglas R.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2004-03-30
Volume: 556
Issue: 1
Pages: 315-324
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.2003.057042
OpenAlex: W2154375091
Cited by: 341
References: 47
Citations by year: 2026: 11 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 12 · 2019: 21 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 24 · 2014: 19 · 2013: 16 · 2012: 32
FWCI: 6.98
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r21ag019365-02)
National Institute on Aging (AG-13038, AG 19365, AG-00828, AG-06537, R37AG013038, R01AG013038, R01AG006537)
National Center for Research Resources (RR-00051, M01RR000051)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: vitamin C, flow-mediated dilation, brachial artery, aging, sedentary lifestyle, physical activity, oxidative stress, endothelial function, nitric oxide, intravenous infusion, oral supplementation
MeSH terms: Administration, Oral, Adult, Aged, Aging, Antioxidants, Ascorbic Acid, Brachial Artery, Humans, Infusions, Intravenous, Male, Middle Aged, Physical Education and Training, Physical Endurance, Regional Blood Flow, Time Factors, Vasodilation

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Effect of acute and chronic ascorbic acid on flow‐mediated dilatation with sedentary and physically active human ageing

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