The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Trandolapril Reduces the Incidence of Atrial Fibrillation After Acute Myocardial Infarction in Patients With Left Ventricular Dysfunction
Abstract
Background —Studies have suggested that ACE inhibitors have an antiarrhythmic effect on ventricular arrhythmias. Whether they have an effect on atrial fibrillation is unknown. Methods and Results —We investigated the effect of ACE inhibition with trandolapril on the incidence of atrial fibrillation in patients with reduced left ventricular function secondary to acute myocardial infarction. The patients in this study were those who qualified for inclusion into the TRAndolapril Cardiac Evaluation (TRACE) study, a randomized double-blind placebo-controlled study and who had sinus rhythm on the ECG obtained at randomization. Patients who fulfilled the criteria for inclusion were randomized to treatment with the ACE inhibitor trandolapril or placebo and were followed up for 2 to 4 years. Development and time to occurrence of atrial fibrillation in one 12-lead ECG recorded at the outpatient visits was the primary end point of this investigation. Of the 1749 patients included in the TRACE study, 1577 had sinus rhythm on the ECG recorded at randomization. Of these patients, 790 were randomized to trandolapril treatment and 787 to placebo treatment. The groups differed only slightly with respect to baseline characteristics. A total of 64 patients developed atrial fibrillation during the 2- to 4-year follow-up period. Significantly more patients developed atrial fibrillation in the placebo group than in the trandolapril group, 5.3% (n=42) versus 2.8% (n=22), respectively, P <0.05. Cox multivariable regression analysis, adjusting for important baseline characteristics, revealed that trandolapril treatment significantly reduced the risk of developing atrial fibrillation (RR, 0.45; 95% CI, 0.26 to 0.76; P <0.01). Conclusions —The results from the present study demonstrate that trandolapril treatment reduces the incidence of atrial fibrillation in patients with left ventricular dysfunction after acute myocardial infarction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575
Køber, L., Torp-Pedersen, C., Carlsen, J. E., Bagger, H., Eliasen, P., Lyngborg, K., Videbæk, J., Cole, D. S., Auclert, L., Pauly, N. C., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512213332503 · Cited by 1,773
Self-citationSt John Sutton, M., Pfeffer, M. A., Plappert, T., Rouleau, J. L., Moyé, L. A., Dagenais, G. R., Lamas, G. A., Klein, M., Sussex, B., & Goldman, S. (1994) · Circulation · doi:10.1161/01.cir.89.1.68 · Cited by 823
Ravelli, F., & Allessie, M. (1997) · Circulation · doi:10.1161/01.cir.96.5.1686 · Cited by 477
Crenshaw, B. S., Ward, S. R., Granger, C. B., Stebbins, A. L., Topol, E. J., & Califf, R. M. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00194-0 · Cited by 404
Pedersen, O. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1352 · Cited by 230
Self-citationThe effect of atrial dilatation on the genesis of atrial arrhythmias
SOLTI, F., VECSEY, T., KEKESI, V, & JUHASZ-NAGY, A. (1989) · Cardiovascular Research · doi:10.1093/cvr/23.10.882 · Cited by 225
Effect of enalapril on ventricular arrhythmias in congestive heart failure
Webster, M. W. I., Andrew Fitzpatrick, M., Gary Nicholls, M., Ikram, H., & Elisabeth Wells, J. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)91186-5 · Cited by 184
Eldar, M., Canetti, M., Rotstein, Z., Boyko, V., Gottlieb, S., Kaplinsky, E., & Behar, S. (1998) · Circulation · doi:10.1161/01.cir.97.10.965 · Cited by 174
Køber, L., Torp-Pedersen, C. T., Carlsen, J. E., Videbæk, R., & Egeblad, H. (1994) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a060443 · Cited by 149
Self-citation
Cited by
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab670 · Cited by 19,442
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805
New ideas about atrial fibrillation 50 years on
Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481
Metadata
- Authors
- Pedersen, O. D., Bagger, H., Køber, L., & Torp-Pedersen, C.
- Venue
- Circulation
- Published
- 1999-07-27
- Volume
- 100
- Issue
- 4
- Pages
- 376-380
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2164029652
- Cited by
- 656
- References
- 14
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Trandolapril Reduces the Incidence of Atrial Fibrillation After Acute Myocardial Infarction in Patients With Left Ventricular Dysfunction. https://app.cochat.ai/papers/10.1161/01.cir.100.4.376
- The paper
- Pedersen, O. D., Bagger, H., Køber, L., & Torp-Pedersen, C. (1999). Trandolapril Reduces the Incidence of Atrial Fibrillation After Acute Myocardial Infarction in Patients With Left Ventricular Dysfunction. Circulation. https://doi.org/10.1161/01.cir.100.4.376
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
