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Late Coronary Occlusion After Intracoronary Brachytherapy
Open accessAbstract
Background —Intracoronary brachytherapy appears to be a promising technology to prevent restenosis. Presently, limited data are available regarding the late safety of this therapeutic modality. The aim of the study was to determine the incidence of late (>1 month) thrombosis after PTCA and radiotherapy. Methods and Results —From April 1997 to March 1999, we successfully treated 108 patients with PTCA followed by intracoronary β-radiation. Ninety-one patients have completed at least 2 months of clinical follow-up. Of these patients, 6.6% (6 patients) presented with sudden thrombotic events confirmed by angiography 2 to 15 months after intervention (2 balloon angioplasty and 4 stent). Some factors (overlapping stents, unhealed dissection) may have triggered the thrombosis process, but the timing of the event is extremely unusual. Therefore, the effect of radiation on delaying the healing process and maintaining a thrombogenic coronary surface is proposed as the most plausible mechanism to explain such late events. Conclusions —Late and sudden thrombosis after PTCA followed by intracoronary radiotherapy is a new phenomenon in interventional cardiology.
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Cited by
Pathological Mechanisms of Fatal Late Coronary Stent Thrombosis in Humans
Farb, A., Burke, A. P., Kolodgie, F. D., & Virmani, R. (2003) · Circulation · doi:10.1161/01.cir.0000091115.05480.b0 · Cited by 478
Coronary in-stent restenosis: Current status and future strategies
Lowe, H. C., Oesterle, S. N., & Khachigian, L. M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01742-9 · Cited by 414
The Road to Bioabsorbable Stents: Reaching Clinical Reality?
Erne, P., Schier, M., & Resink, T. J. (2006) · CardioVascular and Interventional Radiology · doi:10.1007/s00270-004-0341-9 · Cited by 249
Metadata
- Authors
- Costa, M. A., Sabaté, M., van der Giessen, W. J., Kay, I. P., Cervinka, P., Ligthart, J. M. R., Serrano, P., Coen, V. L. M. A., Levendag, P. C., & Serruys, P. W.
- Venue
- Circulation
- Published
- 1999-08-24
- Volume
- 100
- Issue
- 8
- Pages
- 789-792
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2020413887
- Cited by
- 389
- References
- 0
- FWCI
- 48.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Late Coronary Occlusion After Intracoronary Brachytherapy. https://app.cochat.ai/papers/10.1161/01.cir.100.8.789
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- Costa, M. A., Sabaté, M., van der Giessen, W. J., Kay, I. P., Cervinka, P., Ligthart, J. M. R., Serrano, P., Coen, V. L. M. A., Levendag, P. C., & Serruys, P. W. (1999). Late Coronary Occlusion After Intracoronary Brachytherapy. Circulation. https://doi.org/10.1161/01.cir.100.8.789
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