The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Direct In Vivo Evidence Demonstrating Neointimal Migration of Adventitial Fibroblasts After Balloon Injury of Rat Carotid Arteries
Open accessAbstract
Background —Clinical and experimental evidence suggest that the adventitia participates in the response to endoluminal vascular injury. The current study used a direct approach to test the hypothesis that, after balloon injury of the rat carotid artery, adventitial fibroblasts migrate in a luminal direction and contribute to neointima formation. Methods and Results —Primary syngeneic adventitial fibroblasts were stably transduced with retroviral particles coordinating expression of β-galactosidase (LacZ) and introduced into the adventitia of right carotid arteries of rats immediately after balloon injury. At defined times after injury and fibroblast implantation, rats were euthanized, and arterial tissue was examined for detection of LacZ mRNA (reverse transcription polymerase chain reaction), DNA (polymerase chain reaction), and in situ enzymatic activity. LacZ expression was detected in the media 5 days postinjury and in both media and neointima at 7, 10, and 14 days postinjury. LacZ was undetectable in injured vessels that had not been seeded with transduced fibroblasts and was restricted to the adventitia in seeded vessels that were not injured. Conclusions —These observations provide direct demonstration of adventitial fibroblast migration into neointima of arteries after endoluminal injury.
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Adventitial Myofibroblasts Contribute to Neointimal Formation in Injured Porcine Coronary Arteries
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Superoxide Anion From the Adventitia of the Rat Thoracic Aorta Inactivates Nitric Oxide
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Vascular Myofibroblasts: Lessons From Coronary Repair and Remodeling
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Development of intimal lesions after leukocyte migration into the vascular wall.
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Estrogen Inhibits Vascular Smooth Muscle Cell–Dependent Adventitial Fibroblast Migration In Vitro
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Cited by
Smooth muscle cell phenotypic switching in atherosclerosis
Gomez, D., & Owens, G. K. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs115 · Cited by 866
The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells
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Estrogen and Mechanisms of Vascular Protection
Xing, D., Nozell, S., Chen, Y.-F., Hage, F., & Oparil, S. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.182279 · Cited by 379
Self-citationMolecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension
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Perivascular Ancestors of Adult Multipotent Stem Cells
Corselli, M., Chen, C.-W., Crisan, M., Lazzari, L., & Péault, B. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.109.191643 · Cited by 309
Metadata
- Authors
- Li, G., Chen, S.-J., Oparil, S., Chen, Y.-F., & Thompson, J. A.
- Venue
- Circulation
- Published
- 2000-03-28
- Volume
- 101
- Issue
- 12
- Pages
- 1362-1365
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1997810397
- Cited by
- 278
- References
- 10
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Direct In Vivo Evidence Demonstrating Neointimal Migration of Adventitial Fibroblasts After Balloon Injury of Rat Carotid Arteries. https://app.cochat.ai/papers/10.1161/01.cir.101.12.1362
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- Li, G., Chen, S.-J., Oparil, S., Chen, Y.-F., & Thompson, J. A. (2000). Direct In Vivo Evidence Demonstrating Neointimal Migration of Adventitial Fibroblasts After Balloon Injury of Rat Carotid Arteries. Circulation. https://doi.org/10.1161/01.cir.101.12.1362
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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