Cited by 393Mesenchymal stem cell researchAngiogenesis and VEGF in CancerHematopoietic Stem Cell Transplantation

The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells

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Corselli, Mirko, Chen, Chien-Wen, Sun, Bin, Yap, Solomon, Rubin, J. Peter, Péault, Bruno·2012·Stem Cells and Development

Abstract

We previously demonstrated that human pericytes, which encircle capillaries and microvessels, give rise in culture to genuine mesenchymal stem cells (MSCs). This raised the question as to whether all MSC are derived from pericytes. Pericytes and other cells defined on differential expression of CD34, CD31, and CD146 were sorted from the stromal vascular fraction of human white adipose tissue. Besides pericytes, CD34+ CD31- CD146- CD45- cells, which reside in the outmost layer of blood vessels, the tunica adventitia, natively expressed MSC markers and gave rise in culture to clonogenic multipotent progenitors identical to standard bone marrow-derived MSC. Despite common MSC features and developmental properties, adventitial cells and pericytes retain distinct phenotypes and genotypes through culture. However, in the presence of growth factors involved in vascular remodeling, adventitial cells acquire a pericytes-like phenotype. In conclusion, we demonstrate the co-existence of 2 separate perivascular MSC progenitors: pericytes in capillaries and microvessels and adventitial cells around larger vessels.

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Crossref · 10.1089/scd.2011.0200

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Authors
Corselli, M., Chen, C.-W., Sun, B., Yap, S., Rubin, J. P., & Péault, B.
Affiliations
  • University of California, Los Angeles (US)
  • University of Pittsburgh (US)
Corresponding author
Péault, Bruno
Venue
Stem Cells and Development
Published
2011-08-23
Volume
21
Issue
8
Pages
1299-1308
ISSN
  • 1525-8165 (ISSN-L)
  • 1547-3287
  • 1557-8534
OpenAlex
W2147691664
Cited by
393
References
43
Citations by year
2026: 7 · 2025: 10 · 2024: 18 · 2023: 13 · 2022: 16 · 2021: 26 · 2020: 31 · 2019: 41 · 2018: 42 · 2017: 29 · 2016: 38 · 2015: 34 · 2014: 30 · 2013: 28 · 2012: 26
FWCI
14.07
Type
journal article
Language
en
Open access
Locations
  • Stem Cells and Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • University of Pittsburgh
  • National Institutes of Health (TG2-01169)
  • Children's Hospital of Pittsburgh
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Keywords
mesenchymal stem cells, adventitia, pericytes, adventitial cells, stromal vascular fraction, white adipose tissue, CD34, CD31, CD146, multipotent progenitors, vascular remodeling
MeSH terms
Adipose Tissue, Arteries, Cell Separation, Cells, Cultured, Clone Cells, Female, Humans, Immunohistochemistry, Organ Specificity, Veins, Biomarkers, Antigens, CD34, Pericytes, Intercellular Signaling Peptides and Proteins, CD146 Antigen, Mesenchymal Stem Cells

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