The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Estrogen and Mechanisms of Vascular Protection
Open accessAbstract
Estrogen has antiinflammatory and vasoprotective effects when administered to young women or experimental animals that appear to be converted to proinflammatory and vasotoxic effects in older subjects, particularly those that have been hormone free for long periods. Clinical studies have raised many important questions about the vascular effects of estrogen that cannot easily be answered in human subjects. Here we review cellular/molecular mechanisms by which estrogen modulates injury-induced inflammation, growth factor expression, and oxidative stress in arteries and isolated vascular smooth muscle cells, with emphasis on the role of estrogen receptors and the nuclear factor-κB (NFκB) signaling pathway, as well as evidence that these protective mechanisms are lost in aging subjects.
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Cites
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Cited by
Estrogen and the cardiovascular system
Knowlton, A. A., & Lee, A. R. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.03.007 · Cited by 489
Estrogenic endocrine disruptors: Molecular mechanisms of action
Kiyama, R., & Wada-Kiyama, Y. (2015) · Environment International · doi:10.1016/j.envint.2015.05.012 · Cited by 287
Sex and gender differences in cognitive resilience to aging and Alzheimer's disease
Arenaza‐Urquijo, E. M., Boyle, R., Casaletto, K., Anstey, K. J., Vila‐Castelar, C., Colverson, A., Palpatzis, E., Eissman, J. M., Kheng Siang Ng, T., Raghavan, S., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13844 · Cited by 223
Vascular aging: implications for cardiovascular disease and therapy
Ghebre, Y. T., Yakubov, E., Wong, W. T., & Krishnamurthy, P. (2016) · Translational Medicine · doi:10.4172/2161-1025.1000183 · Cited by 87
Lin, J., Kroenke, C. H., Epel, E., Kenna, H. A., Wolkowitz, O. M., Blackburn, E., & Rasgon, N. L. (2011) · Brain Research · doi:10.1016/j.brainres.2010.10.033 · Cited by 86
Metadata
- Authors
- Xing, D., Nozell, S., Chen, Y.-F., Hage, F., & Oparil, S.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2009-03
- Volume
- 29
- Issue
- 3
- Pages
- 289-295
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2124138031
- Cited by
- 379
- References
- 73
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xing, D., Nozell, S., Chen, Y.-F., Hage, F., & Oparil, S. (2009). Estrogen and Mechanisms of Vascular Protection. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.108.182279
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
