The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Effects of Experimental Heart Failure on Atrial Cellular and Ionic Electrophysiology
Abstract
Background —Congestive heart failure (CHF) is frequently associated with atrial fibrillation (AF), but little is known about the effects of CHF on atrial cellular electrophysiology. Methods and Results —We studied action potential (AP) properties and ionic currents in atrial myocytes from dogs with CHF induced by ventricular pacing at 220 to 240 bpm for 5 weeks. Atrial myocytes from CHF dogs were hypertrophied (mean±SEM capacitance, 89±2 pF versus 71±2 pF in control, n=160 cells per group, P <0.001). CHF significantly reduced the density of L-type Ca 2+ current ( I Ca ) by ≈30%, of transient outward K + current ( I to ) by ≈50%, and of slow delayed rectifier current ( I Ks ) by ≈30% without altering their voltage dependencies or kinetics. The inward rectifier, ultrarapid and rapid delayed rectifier, and T-type Ca 2+ currents were not altered by CHF. CHF increased transient inward Na + /Ca 2+ exchanger (NCX) current by ≈45%. The AP duration of atrial myocytes was not altered by CHF at slow rates but was increased at faster rates, paralleling in vivo refractory changes. CHF created a substrate for AF, prolonging mean AF duration from 8±4 to 535±82 seconds ( P <0.01). Conclusions —Experimental CHF selectively decreases atrial I to , I Ca , and I Ks , increases NCX current, and leaves other currents unchanged. The cellular electrophysiological remodeling caused by CHF is quite distinct from that caused by atrial tachycardia, highlighting important differences in the cellular milieu characterizing different clinically relevant AF substrates.
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Cites
Atrial Fibrillation Begets Atrial Fibrillation: A Study in Awake Chronically Instrumented Goats
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Sodium/Calcium Exchange: Its Physiological Implications
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Promotion of Atrial Fibrillation by Heart Failure in Dogs: Atrial Remodeling of a Different Sort
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Self-citationMorillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,037
Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation
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Self-citationWinslow, R. L., Rice, J., Jafri, S., Marbán, E., & O’Rourke, B. (1999) · Circulation Research · doi:10.1161/01.res.84.5.571 · Cited by 797
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Outward K + Current Densities and Kv1.5 Expression Are Reduced in Chronic Human Atrial Fibrillation
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Tachycardia-induced cardiomyopathy: A reversible form of left ventricular dysfunction
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New ideas about atrial fibrillation 50 years on
Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481
Self-citationPathophysiological mechanisms of atrial fibrillation: a translational appraisal
Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273
Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
Nattel, S., Burstein, B., & Dobrev, D. (2008) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.107.754564 · Cited by 1,124
Self-citationGoette, A., Kalman, J. M., Aguinaga, L., Akar, J., Cabrera, J. A., Chen, S. A., Chugh, S. S., Corradi, D., D’Avila, A., Dobrev, D., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 771
Self-citationHeijman, J., Voigt, N., Nattel, S., & Dobrev, D. (2014) · Circulation Research · doi:10.1161/circresaha.114.302226 · Cited by 677
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Metadata
- Authors
- Li, D., Melnyk, P., Feng, J., Wang, Z., Petrecca, K., Shrier, A., & Nattel, S.
- Venue
- Circulation
- Published
- 2000-06-06
- Volume
- 101
- Issue
- 22
- Pages
- 2631-2638
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2158133158
- Cited by
- 373
- References
- 25
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- closed
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