The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Prolonged Antibiotic Prophylaxis After Cardiovascular Surgery and Its Effect on Surgical Site Infections and Antimicrobial Resistance
Open accessAbstract
Background —Despite evidence supporting short antibiotic prophylaxis (ABP), it is still common practice to continue ABP for more than 48 hours after coronary artery bypass graft (CABG) surgery. Methods and Results —To compare the effect of short (<48 hours) versus prolonged (>48 hours) ABP on surgical site infections (SSIs) and acquired antimicrobial resistance, we conducted an observational 4-year cohort study at a tertiary-care center. An experienced infection control nurse performed prospective surveillance of 2641 patients undergoing CABG surgery. The main exposure was the duration of ABP, and main outcomes were the adjusted rate of SSI and the isolation of cephalosporin-resistant enterobacteriaceae and vancomycin-resistant enterococci (acquired antibiotic resistance). Adjustment for confounding was performed by multivariable modeling. A total of 231 SSIs (8.7%) occurred after a median of 16 days, including 93 chest-wound infections (3.5%) and 13 deep-organ-space infections (0.5%). After 1502 procedures using short ABP, 131 SSIs were recorded, compared with 100 SSIs after 1139 operations with prolonged ABP (crude OR, 1.0; CI, 0.8 to 1.3). After adjustment for possible confounding, prolonged ABP was not associated with a decreased risk of SSI (adjusted OR, 1.2; CI, 0.8 to 1.6) and was correlated with an increased risk of acquired antibiotic resistance (adjusted OR, 1.6; CI, 1.1 to 2.6). Conclusions —Our findings confirm that continuing ABP beyond 48 hours after CABG surgery is still widespread; however, this practice is ineffective in reducing SSI, increases antimicrobial resistance, and should therefore be avoided.
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The Timing of Prophylactic Administration of Antibiotics and the Risk of Surgical-Wound Infection
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SINGLE‐VERSUS MULTIPLE–DOSE ANTIMICROBIAL PROPHYLAXIS FOR MAJOR SURGERY: A SYSTEMATIC REVIEW
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Changing Ecology of Bacterial Infections as Related to Antibacterial Therapy
Finland, M. (1970) · Journal of Infectious Diseases · doi:10.1093/infdis/122.5.419 · Cited by 227
Antibiotic prophylaxis for cardiothoracic operations
Kreter, B., & Woods, M. (1992) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)34723-3 · Cited by 208
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The Economic Implications of Infection in Cardiac Surgery
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Cost and morbidity associated with antibiotic prophylaxis in the ICU
Namias, N., Harvill, S., Ball, S., et al. (1999) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(98)00287-7 · Cited by 84
Terpstra, S., Noordhoek, G. T., Voesten, H. G. J., Hendriks, B. J. C., & Degener, J. E. (1999) · Journal of Hospital Infection · doi:10.1053/jhin.1999.0636 · Cited by 78
Cited by
Feldman, D., Pamboukian, S. V., Teuteberg, J. J., Birks, E., Lietz, K., Moore, S. A., Morgan, J. A., Arabia, F., Bauman, M. E., Buchholz, H. W., et al. (2013) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2012.09.013 · Cited by 1,368
Bratzler, D. W., & Houck, P. M. (2005) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2005.01.015 · Cited by 1,163
Diabetes and risk of surgical site infection: a systematic review and meta-analysis
Martin, E. T., Kaye, K. S., Knott, C., Nguyen, H., Santarossa, M., Evans, R., Bertran, E., & Jaber, L. (2016) · Infection Control & Hospital Epidemiology · doi:10.1017/ice.2015.249 · Cited by 666
Bratzler, D. W. (2005) · Archives of Surgery · doi:10.1001/archsurg.140.2.174 · Cited by 578
Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2014 Update
Anderson, D. J., Podgorny, K., Berríos-Torres, S. I., Bratzler, D. W., Dellinger, E. P., Greene, L., Nyquist, A.-C., Saiman, L., Yokoe, D. S., Maragakis, L. L., et al. (2014) · Infection Control & Hospital Epidemiology · doi:10.1017/s0899823x00193869 · Cited by 369
Metadata
- Authors
- Harbarth, S., Samore, M. H., Lichtenberg, D., & Carmeli, Y.
- Venue
- Circulation
- Published
- 2000-06-27
- Volume
- 101
- Issue
- 25
- Pages
- 2916-2921
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2069969451
- Cited by
- 592
- References
- 13
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Harbarth, S., Samore, M. H., Lichtenberg, D., & Carmeli, Y. (2000). Prolonged Antibiotic Prophylaxis After Cardiovascular Surgery and Its Effect on Surgical Site Infections and Antimicrobial Resistance. Circulation. https://doi.org/10.1161/01.cir.101.25.2916
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