The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effectiveness and Limitations of β-Blocker Therapy in Congenital Long-QT Syndrome
Open accessAbstract
Background —β-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness and limitations of β-blockers in this disorder have not been evaluated. Methods and Results —The study population comprised 869 LQTS patients treated with β-blockers. Effectiveness of β-blockers was analyzed during matched periods before and after starting β-blocker therapy, and by survivorship methods to determine factors associated with cardiac events while on prescribed β-blockers. After initiation of β-blockers, there was a significant ( P <0.001) reduction in the rate of cardiac events in probands (0.97±1.42 to 0.31±0.86 events per year) and in affected family members (0.26±0.84 to 0.15±0.69 events per year) during 5-year matched periods. On-therapy survivorship analyses revealed that patients with cardiac symptoms before β-blockers (n=598) had a hazard ratio of 5.8 (95% CI, 3.7 to 9.1) for recurrent cardiac events (syncope, aborted cardiac arrest, or death) during β-blocker therapy compared with asymptomatic patients; 32% of these symptomatic patients will have another cardiac event within 5 years while on prescribed β-blockers. Patients with a history of aborted cardiac arrest before starting β-blockers (n=113) had a hazard ratio of 12.9 (95% CI, 4.7 to 35.5) for aborted cardiac arrest or death while on prescribed β-blockers compared with asymptomatic patients; 14% of these patients will have another arrest (aborted or fatal) within 5 years on β-blockers. Conclusions —β-blockers are associated with a significant reduction in cardiac events in LQTS patients. However, syncope, aborted cardiac arrest, and LQTS-related death continue to occur while patients are on prescribed β-blockers, particularly in those who were symptomatic before starting this therapy.
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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Cited by
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893
Self-citationACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities
Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.032 · Cited by 2,546
Schwartz, P. J., Priori, S. G., Spazzolini, C., Moss, A. J., Vincent, G. M., Napolitano, C., Denjoy, I., Guicheney, P., Breithardt, G., Keating, M. T., et al. (2001) · Circulation · doi:10.1161/01.cir.103.1.89 · Cited by 1,779
Self-citationRole of the Autonomic Nervous System in Modulating Cardiac Arrhythmias
Shen, M. J., & Zipes, D. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.302549 · Cited by 867
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Liu, J. F., Jons, C., Moss, A. J., McNitt, S., Peterson, D. R., Qi, M., Zareba, W., Robinson, J. L., Barsheshet, A., Ackerman, M. J., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.025 · Cited by 126
Self-citationKaufman, E. S. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.02.009 · Cited by 104
Long QT syndrome and short QT syndrome
Zareba, W., & Cygankiewicz, I. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.006 · Cited by 96
Ageing, the autonomic nervous system and arrhythmia: From brain to heart
Chadda, K. R., Ajijola, O. A., Vaseghi, M., Shivkumar, K., Huang, C. L.-H., & Jeevaratnam, K. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.005 · Cited by 77
Atrial Arrhythmias in long-QT syndrome under daily life conditions: a nested case control study
ZELLERHOFF, S., PISTULLI, R., MÖNNIG, G., HINTERSEER, M., BECKMANN, B., KÖBE, J., STEINBECK, G., KÄÄB, S., HAVERKAMP, W., FABRITZ, L., et al. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01339.x · Cited by 71
Syncope in Children and Adolescents
Kanjwal, K., & Calkins, H. (2015) · Cardiology Clinics · doi:10.1016/j.ccl.2015.04.008 · Cited by 52
Effect of atenolol on QTc interval lengthening during hypoglycaemia in type 1 diabetes
Lee, S. P., Harris, N. D., Robinson, R. T., Davies, C., Ireland, R., Macdonald, I. A., & Heller, S. R. (2005) · Diabetologia · doi:10.1007/s00125-005-1796-1 · Cited by 45
Sudden Cardiac Death in Athletes
Link, M. S., & Mark Estes, N. A. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.10.002 · Cited by 26
Metadata
- Authors
- Moss, A. J., Zareba, W., Hall, W. J., Schwartz, P. J., Crampton, R. S., Benhorin, J., Vincent, G. M., Locati, E. H., Priori, S. G., Napolitano, C., Medina, A., Zhang, L., Robinson, J. L., Timothy, K., Towbin, J. A., & Andrews, M. L.
- Venue
- Circulation
- Published
- 2000-02-15
- Volume
- 101
- Issue
- 6
- Pages
- 616-623
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2091453055
- Cited by
- 841
- References
- 1
- FWCI
- 32.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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