The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Secondary Pulmonary Hypertension in Chronic Heart Failure: The Role of the Endothelium in Pathophysiology and Management
Abstract
Abstract —Pulmonary vascular resistance is frequently elevated in patients with chronic left ventricular failure as a result of dysregulation of vascular smooth muscle tone and structural remodeling. The former is reversible over a period of minutes to days by pharmacological vasodilators, whereas the latter is relatively fixed and may resolve only slowly, over months to years. These abnormalities are due, at least in part, to pulmonary vascular endothelial dysfunction that results in impaired nitric oxide availability and increased endothelin expression. In patients with chronic heart failure, the resulting pulmonary hypertension directly affects right ventricular function and may affect exercise capacity, morbidity, and mortality. New treatment strategies, which include the use of agents that increase nitric oxide availability or oppose the actions of endothelin, may improve the structure and function of the pulmonary vasculature in patients with chronic heart failure.
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Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Cited by
2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Humbert, M., Vachiery, J.-L., Gibbs, S., Lang, I., Torbicki, A., Simonneau, G., Peacock, A., Vonk Noordegraaf, A., Beghetti, M., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv317 · Cited by 6,931
Updated clinical classification of pulmonary hypertension
Simonneau, G., Gatzoulis, M. A., Adatia, I., Celermajer, D., Denton, C., Ghofrani, A., Gomez Sanchez, M. A., Krishna Kumar, R., Landzberg, M., Machado, R. F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.029 · Cited by 4,191
Braunwald, E. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800239 · Cited by 1,257
Sildenafil Improves Exercise Hemodynamics and Oxygen Uptake in Patients With Systolic Heart Failure
Lewis, G. D., Lachmann, J., Camuso, J., Lepore, J. J., Shin, J., Martinovic, M. E., Systrom, D. M., Bloch, K. D., & Semigran, M. J. (2007) · Circulation · doi:10.1161/circulationaha.106.626226 · Cited by 353
Long-Term Use of Sildenafil in the Therapeutic Management of Heart Failure
Guazzi, M., Samaja, M., Arena, R., Vicenzi, M., & Guazzi, M. D. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.078 · Cited by 323
Metadata
- Authors
- Moraes, D. L., Colucci, W. S., & Givertz, M. M.
- Venue
- Circulation
- Published
- 2000-10-03
- Volume
- 102
- Issue
- 14
- Pages
- 1718-1723
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2122750966
- Cited by
- 401
- References
- 1
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Secondary Pulmonary Hypertension in Chronic Heart Failure: The Role of the Endothelium in Pathophysiology and Management. https://app.cochat.ai/papers/10.1161/01.cir.102.14.1718
- The paper
- Moraes, D. L., Colucci, W. S., & Givertz, M. M. (2000). Secondary Pulmonary Hypertension in Chronic Heart Failure: The Role of the Endothelium in Pathophysiology and Management. Circulation. https://doi.org/10.1161/01.cir.102.14.1718
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
