The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Transfer of CD4 + T Cells Aggravates Atherosclerosis in Immunodeficient Apolipoprotein E Knockout Mice
Abstract
Background —Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. Methods and Results —To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE —/– mice with immunodeficient scid/scid mice. The offspring showed a 73% reduction in aortic fatty streak lesions when compared with immunocompetent apoE –/– mice. Transfer of CD4 + T cells from apoE –/– to immunodeficient apoE –/– / scid/scid mice increased lesions by 164%. This was associated with the infiltration of transferred T cells into lesions, increased circulating interferon-γ levels, and increased I-A expression in lesions. Conclusions —CD4 + T cells carry disease-promoting immunity in atherosclerosis.
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Self-citationAutoantibody against oxidised LDL and progression of carotid atherosclerosis
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Cited by
INFLAMMATION AND ATHEROSCLEROSIS
Hansson, G. K., Robertson, A.-K. L., & Söderberg-Nauclér, C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100100 · Cited by 1,046
Self-citationThe immunology of atherosclerosis
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Self-citationAccelerated Atherosclerosis in Autoimmune Rheumatic Diseases
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Inflammation and Atherosclerosis: Novel Insights Into Plaque Formation and Destabilization
Stoll, G., & Bendszus, M. (2006) · Stroke · doi:10.1161/01.str.0000226901.34927.10 · Cited by 503
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Metadata
- Authors
- Zhou, X., Nicoletti, A., Elhage, R., & Hansson, G. K.
- Venue
- Circulation
- Published
- 2000-12-12
- Volume
- 102
- Issue
- 24
- Pages
- 2919-2922
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2026563377
- Cited by
- 554
- References
- 21
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transfer of CD4 + T Cells Aggravates Atherosclerosis in Immunodeficient Apolipoprotein E Knockout Mice. https://app.cochat.ai/papers/10.1161/01.cir.102.24.2919
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- Zhou, X., Nicoletti, A., Elhage, R., & Hansson, G. K. (2000). Transfer of CD4 + T Cells Aggravates Atherosclerosis in Immunodeficient Apolipoprotein E Knockout Mice. Circulation. https://doi.org/10.1161/01.cir.102.24.2919
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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