The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Local Delivery of Human Tissue Kallikrein Gene Accelerates Spontaneous Angiogenesis in Mouse Model of Hindlimb Ischemia
Open accessAbstract
Background—Human tissue kallikrein (HK) releases kinins from kininogen. We investigated whether adenovirus-mediated HK gene delivery is angiogenic in the context of ischemia. Methods and Results—Hindlimb ischemia, caused by femoral artery excision, increased muscular capillary density (P<0.001) and induced the expression of kinin B 1 receptor gene (P<0.05). Pharmacological blockade of B 1 receptors blunted ischemia-induced angiogenesis (P<0.01), whereas kinin B 2 receptor antagonism was ineffective. Intramuscular delivery of adenovirus containing the HK gene (Ad.CMV-cHK) enhanced the increase in capillary density caused by ischemia (969±32 versus 541±18 capillaries/mm 2 for control,P<0.001), accelerated blood flow recovery (P<0.01), and preserved energetic charge of ischemic muscle (P<0.01). Chronic blockade of kinin B 1 or B 2 receptors prevented HK-induced angiogenesis. Conclusions—HK gene delivery enhances the native angiogenic response to ischemia. Angiogenesis gene therapy with HK might be applicable to peripheral occlusive vascular disease.
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Citations
Cites
Bioregulation of kinins: kallikreins, kininogens, and kininases.
Bhoola, K. D., Figueroa, C. D., & Worthy, K. (1992) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00058-4 · Cited by 1,744
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Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications
Silvestre, J.-S., Smadja, D. M., & Lévy, B. I. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2013 · Cited by 255
Paracrine control of vascularization and neurogenesis by neurotrophins
Emanueli, C., Schratzberger, P., Kirchmair, R., & Madeddu, P. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705458 · Cited by 62
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Metadata
- Authors
- Emanueli, C., Minasi, A., Zacheo, A., Chao, J., Chao, L., Salis, M. B., Straino, S., Tozzi, M. G., Smith, R., Gaspa, L., Bianchini, G., Stillo, F., Capogrossi, M. C., & Madeddu, P.
- Venue
- Circulation
- Published
- 2001-01-02
- Volume
- 103
- Issue
- 1
- Pages
- 125-132
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2065360915
- Cited by
- 190
- References
- 1
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Local Delivery of Human Tissue Kallikrein Gene Accelerates Spontaneous Angiogenesis in Mouse Model of Hindlimb Ischemia. https://app.cochat.ai/papers/10.1161/01.cir.103.1.125
- The paper
- Emanueli, C., Minasi, A., Zacheo, A., Chao, J., Chao, L., Salis, M. B., Straino, S., Tozzi, M. G., Smith, R., Gaspa, L., Bianchini, G., Stillo, F., Capogrossi, M. C., & Madeddu, P. (2001). Local Delivery of Human Tissue Kallikrein Gene Accelerates Spontaneous Angiogenesis in Mouse Model of Hindlimb Ischemia. Circulation. https://doi.org/10.1161/01.cir.103.1.125
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
