The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Preload Induces Troponin I Degradation Independently of Myocardial Ischemia
Open accessAbstract
Background —Although global ischemia induces troponin I (TnI) degradation, regional ischemia does not. We hypothesized that this disparity is related to preload-induced proteolysis, which varies as a function of the amount of myocardium at risk of ischemia. Methods and Results —Isolated rat hearts were buffer-perfused at controlled levels of preload. Increasing preload to 25 mm Hg in the absence of ischemia produced pronounced TnI degradation (27 kDa versus 31 kDa bands: 16.4±3.6% versus 4.7±1.9% in immediately excised controls, P <0.05). TnI degradation could be blocked by preventing the activation of endogenous calpains with 25 μmol/L calpeptin (4.3±0.6%). This improved function, with left ventricular systolic pressure increasing from 103±4 mm Hg to 137±7 mm Hg ( P <0.05). Eliminating elevations in preload after global ischemia-induced stunning also prevented TnI degradation. Conclusions —Calpain-mediated TnI proteolysis can be dissociated from stunning and arises from elevations in preload rather than ischemia. This raises the possibility that ongoing preload-induced TnI degradation could impair myocardial function long-term.
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Stretch-induced programmed myocyte cell death.
Cheng, W., Li, B., Kajstura, J., Li, P., Wolin, M. S., Sonnenblick, E. H., Hintze, T. H., Olivetti, G., & Anversa, P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118280 · Cited by 640
Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium
Gao, W. D., Atar, D., Liu, Y., Perez, N. G., Murphy, A. M., & Marban, E. (1997) · Circulation Research · doi:10.1161/01.res.0000435855.49359.47 · Cited by 392
McDonough, J. L., Arrell, D. K., & Van Eyk, J. E. (1999) · Circulation Research · doi:10.1161/01.res.84.1.9 · Cited by 317
Transgenic Mouse Model of Stunned Myocardium
Murphy, A. M., Kögler, H., Georgakopoulos, D., McDonough, J. L., Kass, D. A., Van Eyk, J. E., & Marbán, E. (2000) · Science · doi:10.1126/science.287.5452.488 · Cited by 228
Cardiac Troponin T and I in End-Stage Renal Failure
Wayand, D., Baum, H., Schätzle, G., Schärf, J., & Neumeier, D. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.9.1345 · Cited by 178
Di Lisa, F., De Tullio, R., Salamino, F., Barbato, R., Melloni, E., Siliprandi, N., Schiaffino, S., & Pontremoli, S. (1995) · Biochemical Journal · doi:10.1042/bj3080057 · Cited by 167
Cardiac Troponin I Is Modified in the Myocardium of Bypass Patients
McDonough, J. L., Labugger, R., Pickett, W., Tse, M. Y., MacKenzie, S., Pang, S. C.-N., Atar, D., Ropchan, G. V., & Eyk, J. E. V. (2001) · Circulation · doi:10.1161/01.cir.103.1.58 · Cited by 129
Thomas, S. A., Fallavollita, J. A., Lee, T., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.5.446 · Cited by 80
Self-citationSherman, A. J., Klocke, F. J., Decker, R. S., Decker, M. L., Kozlowski, K. A., Harris, K. R., Hedjbeli, S., Yaroshenko, Y. N., Nakamura, S., Parker, M. A., et al. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.4.h1320 · Cited by 58
Kositprapa, C., Zhang, B., Berger, S. B., Canty, J. M., & Lee, T. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007160702275 · Cited by 46
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Cited by
Cardiomyocyte stiffness in diastolic heart failure
Borbély, A., van der Velden, J., Papp, Z., Bronzwaer, J. G. F., Edes, I., Stienen, G. J. M., & Paulus, W. J. (2005) · Circulation · doi:10.1161/01.cir.0000155257.33485.6d · Cited by 536
Cardiac troponins: from myocardial infarction to chronic disease
Park, K. C., Gaze, D. C., Collinson, P. O., & Marber, M. S. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx183 · Cited by 510
Exercise-Induced Cardiac Troponin Elevation
Shave, R., Baggish, A., George, K., Wood, M., Scharhag, J., Whyte, G., Gaze, D., & Thompson, P. D. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.037 · Cited by 447
Pathobiology of Troponin Elevations
White, H. D. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.029 · Cited by 381
Witt, S. H., Granzier, H., Witt, C. C., & Labeit, S. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.05.021 · Cited by 310
Metadata
- Authors
- Feng, J., Schaus, B. J., Fallavollita, J. A., Lee, T.-C., & Canty, J. M.
- Venue
- Circulation
- Published
- 2001-04-24
- Volume
- 103
- Issue
- 16
- Pages
- 2035-2037
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2051521078
- Cited by
- 287
- References
- 11
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Feng, J., Schaus, B. J., Fallavollita, J. A., Lee, T.-C., & Canty, J. M. (2001). Preload Induces Troponin I Degradation Independently of Myocardial Ischemia. Circulation. https://doi.org/10.1161/01.cir.103.16.2035
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