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Cited by 378Atrial Fibrillation Management and OutcomesVenous Thromboembolism Diagnosis and ManagementAcute Ischemic Stroke Management

The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.

New-Onset Atrial Fibrillation: Sex Differences in Presentation, Treatment, and Outcome

Humphries, Karin H., Kerr, Charles R., Connolly, Stuart J., Klein, George, Boone, John A., Green, Martin, Sheldon, Robert, Talajic, Mario, Dorian, Paul, Newman, David·2001·Circulation
DOI 10.1161/01.cir.103.19.2365
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Abstract

Background —Although sex differences in coronary artery disease have received considerable attention, few studies have dealt with sex differences in the most common sustained cardiac arrhythmia, atrial fibrillation (AF). Differences in presentation and clinical course may dictate different approaches to detection and management. We sought to examine sex-related differences in presentation, treatment, and outcome in patients presenting with new-onset AF. Methods and Results —The Canadian Registry of Atrial Fibrillation (CARAF) enrolled subjects at the time of first ECG-confirmed diagnosis of AF. Participants were followed at 3 months, at 1 year, and annually thereafter. Treatment was at the discretion of the patients’ physicians and was not directed by CARAF investigators. Baseline and follow-up data collection included a detailed medical history, clinical, ECG, and echocardiographic measures, medication history, and therapeutic interventions. Three hundred thirty-nine women and 560 men were followed for 4.14±1.39 years. Compared with men, women were older at the time of presentation, more likely to seek medical advice because of symptoms, and experienced significantly higher heart rates during AF. Compared with older men, older women were half as likely to receive warfarin and twice as likely to receive acetylsalicylic acid. Compared with men on warfarin, women on warfarin were 3.35 times more likely to experience a major bleed. Conclusions —Anticoagulants are underused in older women with AF relative to older men with AF, despite comparable risk profiles. Women receiving warfarin have a significantly higher risk of major bleeding, suggesting the need for careful monitoring of anticoagulant intensity in women.

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Crossref · 10.1161/01.cir.103.19.2365

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Research works printed but not linked: 5

  1. 10.1161/circ.95.1.252 · DOI
  2. 10.1001/archinte.1995.00430050045005 · DOI
  3. 10.1001/archinte.1994.00420130036007 · DOI
  4. 10.1001/archinte.1996.00440040081009 · DOI
  5. 10.1161/circ.95.11.2508 · DOI

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Metadata

Authors
Humphries, K. H., Kerr, C. R., Connolly, S. J., Klein, G., Boone, J. A., Green, M., Sheldon, R., Talajic, M., Dorian, P., & Newman, D.
Affiliations
Western University (CA)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-05-15
Volume
103
Issue
19
Pages
2365-2370
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.103.19.2365
OpenAlex
W2068229127
Cited by
378
References
29
Citations by year
2026: 5 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 19 · 2021: 24 · 2020: 12 · 2019: 16 · 2018: 23 · 2017: 25 · 2016: 22 · 2015: 26 · 2014: 19 · 2013: 20 · 2012: 27
FWCI
5.85
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
new-onset atrial fibrillation, sex differences, women, anticoagulation, warfarin, major bleeding, aspirin, stroke prevention, older women, heart rate, clinical features
MeSH terms
Anticoagulants, Atrial Fibrillation, Cardiovascular Diseases, Cause of Death, Electrocardiography, Female, Follow-Up Studies, Hemorrhage, Humans, Male, Middle Aged, Myocardial Infarction, Registries, Sex Factors, Warfarin, Cohort Studies, Survival Rate, Treatment Outcome, Stroke

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