The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The Hemodynamic and Metabolic Interrelationships in the Activity of Epinephrine, Norepinephrine and the Thyroid Hormones
Open accessAbstract
The hemodynamic and metabolic effects of a total sympathetic block and of the infusion of l -epinephrine or l -norepinephrine were studied in 27 euthyroid dogs and in 31 thyroid-fed dogs. The physiologic changes produced by increased concentrations of the thyroid hormones were abolished by preventing the reflex release of epinephrine and norepinephrine with a total sympathetic block. The inotropic, chronotropic and calorigenic effects of l -epinephrine and of l -norepinephrine were found to be increased by thyroid feeding. It is concluded that there is a dynamic interrelationship between the thyroid hormones and those of the adrenal medulla and sympathetic nerve endings. The hemodynamic and metabolic changes of thyrotoxicosis are not the result of the isolated activity of the thyroid hormones, but rather are due to the physiologic effects of epinephrine and norepinephrine, as augmented by the thyroid hormones. Studies indicate that l -norepinephrine is the predominant mediator of the changes produced by thyroid feeding.
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Citations
Cites
Singer, R. B., & Hastings, A. B. (1948) · Medicine · doi:10.1097/00005792-194805000-00003 · Cited by 608
DETERMINATION OF PROTEIN-BOUND IODINE
Barker, S. B. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57442-1 · Cited by 210
Mechanism of Action of the Thyroid Hormone
Barker, S. B. (1951) · Physiological Reviews · doi:10.1152/physrev.1951.31.3.205 · Cited by 145
Effect of variation in thyroid function on the pressor response to norepinephrine in man.
Schneckloth, R. E., Kurland, G., & FREEDBERG, A. S. (1953) · PubMed · Cited by 57
ADRENO-SYMPATHOGENIC HEART DISEASE (NEUROHORMONAL FACTORS IN PATHOGENESIS AND TREATMENT)
Raab, W. H.-M. (1948) · Annals of Internal Medicine · doi:10.7326/0003-4819-28-5-1010 · Cited by 39
Rosenblum, H. (1933) · Archives of Internal Medicine · doi:10.1001/archinte.1933.00150210109008 · Cited by 39
THE IMPORTANCE OF THE THYROID IN MAINTAINING AN ADEQUATE PRODUCTION OF HEAT DURING EXPOSURE TO COLD
Ring, G. C. (1942) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1942.137.3.582 · Cited by 36
Sawyer, M. E. M., & Brown, M. G. (1934) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1934.110.3.620 · Cited by 33
The effect of thyroid feeding on the oxygen consumption of the heart and of other tissues
Dock, W., & Lewis, J. K. (1932) · The Journal of Physiology · doi:10.1113/jphysiol.1932.sp002857 · Cited by 26
INFLUENCE OF THE THYROID HORMONE ON THE EFFECTOR SYSTEMS OF THE MAMMALIAN HEART
Hoffmann, F., Hoffmann, E. J., & Talesnik, J. (1947) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1947.148.3.689 · Cited by 24
Cited by
Buccino, R. A., Spann, J. F., Pool, P. E., Sonnenblick, E. H., & Braunwald, E. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105658 · Cited by 384
Catecholamine sensitivity, thyroid hormone and the heart
Levey, G. S. (1971) · The American Journal of Medicine · doi:10.1016/0002-9343(71)90331-7 · Cited by 160
REDUCTION OF PLASMA TRIIODOTHYRONINE (T3) INDUCED BY PROPRANOLOL
LOTTI, G., DELITALA, G., DEVILLA, L., ALAGNA, S., & MASALA, A. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb03322.x · Cited by 68
Metadata
- Authors
- BREWSTER, W. R., ISAACS, J. P., OSGOOD, P. F., & KING, T. L.
- Venue
- Circulation
- Published
- 1956-01
- Volume
- 13
- Issue
- 1
- Pages
- 1-20
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2005021866
- Cited by
- 351
- References
- 12
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Hemodynamic and Metabolic Interrelationships in the Activity of Epinephrine, Norepinephrine and the Thyroid Hormones. https://app.cochat.ai/papers/10.1161/01.cir.13.1.1
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- BREWSTER, W. R., ISAACS, J. P., OSGOOD, P. F., & KING, T. L. (1956). The Hemodynamic and Metabolic Interrelationships in the Activity of Epinephrine, Norepinephrine and the Thyroid Hormones. Circulation. https://doi.org/10.1161/01.cir.13.1.1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
