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Vasodepressor syncope; factors influencing cardiac output
Abstract
Vasodepressor syncope is characterized hemodynamically by a sudden fall in total peripheral resistance with little associated change in cardiac output. The failure of the cardiac output to compensate for the fall in peripheral resistance is a striking feature of the fainting reaction. Possible explanations for this phenomenon are the presence of neurogenic myocardial inhibition or markedly limited volume of blood available to the heart. The effects of atropine injections, inflation of antigravity suit, negative pressure breathing, and albumin infusions on the syncopal reaction were studied. Results favor the causative role of limited venous inflow in the cardiac output response.
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In most cases, hypocapnia may be an important factor accentuating cardiovascular embarrassment in syncope, but additional predisposing factors must be invoked to explain actual fainting.
“Thus, in most cases, hypocapnia may be “an important factor accentuating cardiovascular embarrassment” in syncope (Weissler et al., 1957, p.881), but most probably, additional predisposing factors must be invoked to explain actual fainting.”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Weissler et al., 1957
Apneas were noted by other investigators in periods leading up to syncope.
“Similarly, apneas were noted by other investigators in periods leading up to syncope (e.g., Weissler et al., 1957).”
From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Weissler et al., 1957
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Management of Vasovagal Syncope: Controlling or Aborting Faints by Leg Crossing and Muscle Tensing
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Hemodynamic changes during spontaneous vasovagal reactions
Glick, G., & Yu, P. N. (1963) · The American Journal of Medicine · doi:10.1016/0002-9343(63)90037-8 · Cited by 116
Verheyden, B., Liu, J., van Dijk, N., Westerhof, B. E., Reybrouck, T., Aubert, A. E., & Wieling, W. (2008) · Heart Rhythm · doi:10.1016/j.hrthm.2008.09.003 · Cited by 101
Decrease in cardiac output and muscle sympathetic activity during vasovagal syncope
Jardine, D. L., Melton, I. C., Crozier, I. G., English, S., Bennett, S. I., Frampton, C. M., & Ikram, H. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00640.2001 · Cited by 86
The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm
Ritz, T., Meuret, A. E., & Ayala, E. S. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.05.007 · Cited by 74
“Thus, in most cases, hypocapnia may be “an important factor accentuating cardiovascular embarrassment” in syncope (Weissler et al., 1957, p.881), but most probably, additional predisposing factors must be invoked to explain actual fainting.”
BackgroundEffects of cholinergic and β-adrenergic blockade on orthostatic tolerance in healthy subjects
Convertino, V. A., & Sather, T. M. (2000) · Clinical Autonomic Research · doi:10.1007/bf02322256 · Cited by 47
Pathophysiology of neurally mediated syncope: Role of cardiac output and total peripheral resistance
Fu, Q., & Levine, B. D. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.07.004 · Cited by 39
Assessment of the vasodepressor reflex in carotid sinus syndrome
Solari, D., Maggi, R., Oddone, D., Solano, A., Croci, F., Donateo, P., Wieling, W., & Brignole, M. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.001093 · Cited by 32
SANTOS, R. Q. D., SMIDT, L., SUZIGAN, B. H., DE SOUZA, L. V., & BARBISAN, J. N. (2013) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12069 · Cited by 9
Metadata
- Authors
- WEISSLER, A. M., WARREN, J. V., ESTES, E. H., MCINTOSH, H. D., & LEONARD, J. J.
- Affiliations
- Duke University (US)
- ORCID
- ESTES, E. H.
- Venue
- Circulation
- Published
- 1957-06
- Volume
- 15
- Issue
- 6
- Pages
- 875-882
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2053336195
- Cited by
- 125
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Keywords
- vasodepressor syncope, syncope, systemic vascular resistance, cardiac output, atropine, negative pressure breathing, albumin infusion, hemodynamics
- MeSH terms
- Cardiac Output, Heart, Humans, Syncope, Syncope, Vasovagal
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