Ventricular Fibrillation: A Possible Mechanism of Sudden Death in Patients with Wolff-Parkinson-White Syndrome
Open accessAbstract
A case of Wolff-Parkinson-White syndrome associated with ventricular fibrillation is presented. The control of recurrent ventricular fibrillation with large doses of digitalis and other antiarrhythmic drugs, including propranolol, lidocaine, procainamide, and quinidine, is discussed. As far as we can determine, this is the first human case in which the precise onset of ventricular fibrillation was documented. Possible mechanisms are presented that may produce ventricular fibrillation in patients with Wolff-Parkinson-White syndrome associated with atrial flutter or fibrillation.
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Atrial fibrillation with a fast ventricular response is potentially life-threatening in patients with WPW syndrome because it can degenerate into ventricular fibrillation.
“Atrial fibrillation with fast ventricular response is a potentially lifethreatening arrhythmia in patients with WPW syndrome due to degeneration in VF. 306,307”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [307]
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Cites
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- Authors
- DREIFUS, L. S., HAIAT, R., WATANABE, Y., ARRIAGA, J., & REITMAN, N.
- Affiliations
- From the Division of Cardiology, Hahnemann Medical College, Philadelphia, Pennsylvania, and Middlesex General Hospital, New Brunswick, New Jersey.
- ORCID
- WATANABE, YOSHIO
- Venue
- Circulation
- Published
- 1971-04
- Volume
- 43
- Issue
- 4
- Pages
- 520-527
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1990331716
- Cited by
- 316
- References
- 4
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 7 · 2012: 11
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- ventricular fibrillation, Wolff-Parkinson-White syndrome, atrial flutter, atrial fibrillation, antiarrhythmic drugs, digitalis, propranolol, lidocaine, procainamide, quinidine, ventricular arrhythmia mechanisms
- MeSH terms
- Anti-Arrhythmia Agents, Atrial Fibrillation, Atrial Flutter, Death, Sudden, Female, Heart Conduction System, Humans, Middle Aged, Pacemaker, Artificial, Ventricular Fibrillation, Wolff-Parkinson-White Syndrome
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