The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cholesterol Production in Obesity
Open accessAbstract
Sterol-balance studies were performed in 10 control subjects, 10 normolipidemic obese patients, and 10 hypertriglyceridemic (type IV, mostly obese) patients on a low-cholesterol solid-food diet. Fecal elimination of cholesterol was markedly elevated in the overweight patients and tended to be high in the hypertriglyceridemic subjects also. A significant correlation was found between body weight and fecal excretion of neutral, acidic, and total steroids, indicating that the greater the body weight the higher was the rate of cholesterol synthesis. Sterol-balance data in obese subjects showed that excess daily cholesterol production roughly amounted to 20 mg/kg of adipose tissue. The control subjects produced only 12 mg/kg of body weight daily. Thus, obesity is associated with an increased rate of cholesterol synthesis in man. However, the correlation between serum cholesterol concentration and cholesterol production was low, suggesting that the overall rate of cholesterol synthesis was not the only factor determining the serum cholesterol level. That enhanced cholesterol production is not an irreversible phenomenon in obese subjects was indicated by the normalization of sterol-balance values in three overweight patients after their weights had been reduced by total fast followed by a low-calorie diet.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fat Transport in Lipoproteins — An Integrated Approach to Mechanisms and Disorders
Fredrickson, D. S., Levy, R. I., & Lees, R. S. (1967) · New England Journal of Medicine · doi:10.1056/nejm196701052760107 · Cited by 1,910
CORONARY HEART DISEASE IN SEVEN COUNTRIES
(1971) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1971.tb50629.x · Cited by 1,599
Quantitative isolation and gas–liquid chromatographic analysis of total fecal bile acids
Grundy, S. M., Ahrens, E. H., & Miettinen, T. A. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39310-x · Cited by 883
Self-citationMiettinen, T. A., Ahrens, E. H., & Grundy, S. M. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39311-1 · Cited by 754
Self-citationDetermination of serum triglycerides
Carlson, L. A. (1963) · Journal of Atherosclerosis Research · doi:10.1016/s0368-1319(63)80012-5 · Cited by 689
Bolin, D. W., King, R. P., & Klosterman, E. W. (1952) · Science · doi:10.1126/science.116.3023.634 · Cited by 466
Regulation of Cholesterol Metabolism
Dietschy, J. M., & Wilson, J. D. (1970) · New England Journal of Medicine · doi:10.1056/nejm197005212822105 · Cited by 337
Grundy, S. M., & Ahrens, E. H. (1969) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42653-7 · Cited by 321
Connor, W. E., Witiak, D. T., Stone, D. B., & Armstrong, M. L. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106102 · Cited by 279
Relation of Body Weight to Development of Coronary Heart Disease: The Framingham Study
KANNEL, W. B., LEBAUER, E. J., DAWBER, T. R., & MCNAMARA, P. M. (1967) · Circulation · doi:10.1161/01.cir.35.4.734 · Cited by 274
Cited by
Dietschy, J., Turley, S., & Spady, D. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35728-x · Cited by 874
Effects of obesity and caloric intake on biliary lipid metabolism in man.
Bennion, L. J., & Grundy, S. M. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108180 · Cited by 386
BRAY, G. A. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-6-1052 · Cited by 385
Biliary lipid secretion in cholesterol gallstone disease. The effect of cholecystectomy and obesity.
Shaffer, E. A., & Small, D. M. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108705 · Cited by 345
Wang, F., Zheng, J., Yang, B., Jiang, J., Fu, Y., & Li, D. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002408 · Cited by 340
Metadata
- Authors
- MIETTINEN, T. A.
- Venue
- Circulation
- Published
- 1971-11
- Volume
- 44
- Issue
- 5
- Pages
- 842-850
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1984143520
- Cited by
- 258
- References
- 22
- FWCI
- 21.85
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cholesterol Production in Obesity. https://app.cochat.ai/papers/10.1161/01.cir.44.5.842
- The paper
- MIETTINEN, T. A. (1971). Cholesterol Production in Obesity. Circulation. https://doi.org/10.1161/01.cir.44.5.842
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
