Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cholesterol is a major and essential component of the brain, which must be produced there exclusively via synthesis as cholesterol-rich lipoproteins cannot cross the blood brain barrier.
“Cholesterol is a major and essential component of the brain, which must be produced there exclusively via synthesis as cholesterol-rich lipoproteins cannot cross the blood brain barrier (BBB)29.”
From A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) · cites this paper as [29]
Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703 · see citing works
Brown, G., Albers, J. J., Fisher, L. D., Schaefer, S. M., Lin, J.-T., Kaplan, C., Zhao, X.-Q., Bisson, B. D., Fitzpatrick, V. F., & Dodge, H. T. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011083231901 · Cited by 2,159 · see citing works
Sherrill, B. C., & Dietschy, J. M. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)62331-8 · Cited by 197 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Gylling, H., Plat, J., Turley, S., Ginsberg, H. N., Ellegård, L., Jessup, W., Jones, P. J., Lütjohann, D., Maerz, W., Masana, L., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.043 · Cited by 529 · see citing works
Self-citationCentral nervous system: cholesterol turnover, brain development and neurodegeneration
Dietschy, J. M. (2009) · bchm · doi:10.1515/bc.2009.035 · Cited by 394 · see citing works
Self-citationIs it time to reevaluate methyl balance in humans?
Stead, L. M., Brosnan, J. T., Brosnan, M. E., Vance, D. E., & Jacobs, R. L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.1.5 · Cited by 278 · see citing works
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
Buchovecky, C. M., Turley, S. D., Brown, H. M., Kyle, S. M., McDonald, J. G., Liu, B., Pieper, A. A., Huang, W., Katz, D. M., Russell, D. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2714 · Cited by 234 · see citing works
Self-citationEisenberg, D. T. A., Kuzawa, C. W., & Hayes, M. G. (2010) · American Journal of Physical Anthropology · doi:10.1002/ajpa.21298 · Cited by 231 · see citing works
Thyroid hormone signaling and the liver
Ritter, M. J., Amano, I., Hollenberg, A. N., et al. (2020) · Hepatology · doi:10.1002/hep.31296 · Cited by 188 · see citing works
Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol
Otte, K., Kranz, H., Kober, I., Thompson, P., Hoefer, M., Haubold, B., Remmel, B., Voss, H., Kaiser, C., Albers, M., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.864-872.2003 · Cited by 176 · see citing works
Review: Transport of maternal cholesterol to the fetal circulation
Woollett, L. A. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.011 · Cited by 173 · see citing works
Shibata, N., Arita, M., Misaki, Y., Dohmae, N., Takio, K., Ono, T., Inoue, K., & Arai, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041620398 · Cited by 108 · see citing works
PCSK9 inhibition in the management of familial hypercholesterolemia
Ogura, M. (2018) · Journal of Cardiology · doi:10.1016/j.jjcc.2017.07.002 · Cited by 84 · see citing works
Correa-Cerro, L. S., Wassif, C. A., Kratz, L., Miller, G. F., Munasinghe, J. P., Grinberg, A., Fliesler, S. J., & Porter, F. D. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl003 · Cited by 75 · see citing works
Rebholz, S. L., Jones, T., Herrick, R. L., Xie, C., Calafat, A. M., Pinney, S. M., & Woollett, L. A. (2016) · Toxicology Reports · doi:10.1016/j.toxrep.2015.11.004 · Cited by 69 · see citing works
Cholesterol: From Feeding to Gene Regulation
Martini, C., & Pallottini, V. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0049-y · Cited by 53 · see citing works
de Vree, J. M. L., Romijn, J. A., Mok, K. S., Mathus-Vliegen, L. M., Stoutenbeek, C. P., Ostrow, J. D., Tytgat, G. N., Sauerwein, H. P., Elferink, R. P. O., & Groen, A. K. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.1.70 · Cited by 35 · see citing works
Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels
Nguyen, H., Glaaser, I. W., & Slesinger, P. A. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1386645 · Cited by 29 · see citing works
- Authors
- Dietschy, J., Turley, S., & Spady, D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1993-10
- Volume
- 34
- Issue
- 10
- Pages
- 1637-1659
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2151602225
- Cited by
- 874
- References
- 3
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 10 · 2023: 13 · 2022: 19 · 2021: 29 · 2020: 26 · 2019: 28 · 2018: 23 · 2017: 25 · 2016: 26 · 2015: 22 · 2014: 22 · 2013: 32 · 2012: 29
- FWCI
- 35.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Heart, Lung, and Blood Institute (HL09610)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- liver, cholesterol homeostasis, low-density lipoprotein, lipoprotein metabolism, cross-species comparison
- MeSH terms
- Animals, Biological Transport, Cholesterol, Dietary Fats, Homeostasis, Humans, Cholesterol, LDL, Liver, Genetic Variation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
