Cardiac performance and mortality early after intracardiac surgery in infants and young children.
Open accessAbstract
One hundred thirty-nine infants and small children less than 48 months old were studied during the first 72 hours after intracardiac surgery for a variety of lesions. The hospital mortality rate was 19.4% (27 patients); 16 of those dying succumbed from acute cardiac failure. Deaths from acute cardiac failure were commonest in patients with low cardiac index (CI), and a continuous probability curve relates the two. The mean CI for all patients was 2.51 plus or minus 0.794 l-min minus 1-m minus 2, and that for individual patients varied between 0.6 and 4.9. Cardiac output normalized by surface area (cardiac index) correlated weakly with age. cardiac output normalized by weight did not correlate with age; Mean mixed venous oxygen partial pressure (P-vO2)varied between 17 and 60 mm Hg, and the weighted mean for the group of 80 patients in whom it was obtained was 33.1 plus or minus 6.57 mm Hg. CI and P-vO2 were only slightly related. Acute cardiac deaths occurred more frequently in patients with low P-vO2. Acute cardiac death was more reliably predicted using CI and P-vO2 together than either alone. The average of the mean arterial pressure was 80.5 plus or minus 2.53 mm Hg, and this did not correlate with CI. Mean average systemic vascular resistance was 30.0 plus or minus 8.395 SRU. We conclude that in such patients treatment should be directed toward keeping CI greater than 2.0 l-min minus 1-m minus 2 and P-vO2 greater than 30 mm Hg; that the possibility of maintaining adequate CI and P-vO2 is not related to the age of the patient but is related to the malformation treated; and that a therapeutic trial of reducing left ventricular afterload is indicated in some of these patients.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Approximately 25% of children after cardiac surgery have a cardiac index less than 2.0 L/min/m2.
“Approximately 25% of children experience a decrease in cardiac index of less than 2 L/min/m2 within 6-18 hours after cardiac surgery.”
From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [1]
Cited by
Sorted by citations
Wernovsky, G., Wypij, D., Jonas, R. A., Mayer, J. E., Hanley, F. L., Hickey, P. R., Walsh, A. Z., Chang, A. C., Castañeda, A. R., Newburger, J. W., et al. (1995) · Circulation · doi:10.1161/01.cir.92.8.2226 · Cited by 1,010 · see citing works
Brierley, J., Carcillo, J., Choong, K., Cornell, T. T., Caen, A. D., Deymann, A., Doctor, A., Davis, A., Duff, J., Dugas, M., et al. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819323c6 · Cited by 999 · see citing works
Hoffman, T. M., Wernovsky, G., Atz, A. M., Kulik, T. J., Nelson, D. P., Chang, A. C., Bailey, J. M., Akbary, A., Kocsis, J. F., Kaczmarek, R., et al. (2003) · Circulation · doi:10.1161/01.cir.0000051365.81920.28 · Cited by 772 · see citing works
Davis, A. L., Carcillo, J. A., Aneja, R. K., Deymann, A. J., Lin, J. C., Nguyen, T. C., Okhuysen‐Cawley, R., Relvas, M. S., Rozenfeld, R. A., Skippen, P. W., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002425 · Cited by 679 · see citing works
Wernovsky, G. (2006) · Cardiology in the Young · doi:10.1017/s1047951105002398 · Cited by 335 · see citing works
Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery.
Chang, A. C., Atz, A., Wernovsky, G., Burke, R., & Wessel, D. (1995) · Critical Care Medicine · doi:10.1097/00003246-199511000-00018 · Cited by 263 · see citing works
Davidson, J., Tong, S., Hancock, H. S., Hauck, A., da Cruz, E. D., & Kaufman, J. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2544-x · Cited by 225 · see citing works
“death in the postoperative period [1].”
The Host Response to Sepsis and Developmental Impact
Wynn, J. L., Cornell, T. T., Wong, H. R., Shanley, T. P., & Wheeler, D. S. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3301 · Cited by 210 · see citing works
Mortality and Functional Morbidity After Use of PALS/APLS by Community Physicians
Carcillo, J., Kuch, B., Han, Y. Y., Day, S. E., Greenwald, B., McCloskey, K., Pearson-Shaver, A., & Orr, R. (2009) · Pediatrics · doi:10.1542/peds.2008-1967 · Cited by 177 · see citing works
Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study
Hoffman, T. M., Wernovsky, G., Atz, A. M., Bailey, J. M., Akbary, A., Kocsis, J. F., Nelson, D. P., Chang, A. C., Kulik, T. J., Spray, T. L., et al. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120305 · Cited by 167 · see citing works
“These include (1) primary composite end point 14 days after randomization, (2) individual components of the primary composite end point 14 days after randomization, (3) total urine output (milliliters per kilogram per hour) in the first 36 hours after initiation of study medication, (4) creatinine clearance at 36 hour…”
BackgroundWu, C., Honarmand, A., Schnell, S., Kuhn, R., Schoeneman, S., Ansari, S., Carr, J., Markl, M., & Shaibani, A. (2016) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.115.002657 · Cited by 141 · see citing works
“been reported as a predictor of acute cardiac death in young children.(15) Recently, Jefferson et al reported that low cardiac index is associated with incident dementia and Alzheimer’s disease.”
BackgroundSurgical treatment of tetralogy of Fallot with pulmonary atresia.
Alfieri, O., Blackstone, E., Kirklin, J., Pacifico, A., & Bargeron, L. (1978) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)39573-x · Cited by 105
Self-citationNecrotizing enterocolitis in neonates with congenital heart disease.
Giannone, P., Luce, W. A., Nankervis, C., Hoffman, T., & Wold, L. (2008) · Life Science · doi:10.1016/j.lfs.2007.09.036 · Cited by 104 · see citing works
Jones, M. P., & Ferrans, V. (1977) · American Journal of Cardiology · doi:10.1016/s0002-9149(77)80221-x · Cited by 93 · see citing works
Causes of death after congenital heart surgery.
Ma, M., Gauvreau, K., Allan, C. K., Mayer, J., & Jenkins, K. (2007) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.10.073 · Cited by 89 · see citing works
Hyperkalemic cardioplegia for adult and pediatric surgery: end of an era?
Dobson, G. P., Faggian, G. G., Onorati, F., & Vinten‐Johansen, J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00228 · Cited by 78 · see citing works
“Stunning occurs in about 10% of adults following cardiac surgery (Weisel, 1993; Vaage and Valen, 1993; Mangano, 1995; Spinale, 1999; Flack et al., 2000; Chang et al., 2002; Anselmi et al., 2004) and in 10–15% of pediatric patients (Parr et al., 1975; Booker, 1998; Ravishankar et al., 2003).”
BackgroundPediatric Sepsis – Part I: “Children are not small adults!”
Wheeler, D., Wong, H., & Zingarelli, B. (2011) · The Open Inflammation Journal · doi:10.2174/1875041901104010004 · Cited by 84
“These findings have been confirmed in multiple studies [9, 62-66].”
ResultPro: NIRS is "standard of care" for postoperative management.
Tweddell, J., Ghanayem, N., & Hoffman, G. (2010) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2010.02.008 · Cited by 81 · see citing works
Lechner, E., Hofer, A., Leitner-Peneder, G., Freynschlag, R., Mair, R., Weinzettel, R., Rehak, P., & Gombotz, H. (2012) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3182455571 · Cited by 79 · see citing works
Sood, E., Benzaquen, J. S., Davies, R. R., Woodford, E. J., & Pizarro, C. (2012) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.10.033 · Cited by 74 · see citing works
Shih, C.-Y., Sapru, A., Oishi, P. E., Azakie, A., Karl, T. R., Harmon, C., Asija, R., Adatia, I., & Fineman, J. R. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.10.052 · Cited by 67 · see citing works
Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease
K. Chandler, H., & Kirsch, R. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666151119164647 · Cited by 74 · see citing works
“The LCOS was first described by Parr and colleagues in 1975 [1].”
BackgroundDo weekends or evenings matter in a pediatric intensive care unit?*
Hixson, E. D., Davis, S., Morris, S., & Harrison, A. M. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000165564.01639.cb · Cited by 73 · see citing works
Stocker, C., Shekerdemian, L., Nørgaard, M., Brizard, C., Mynard, J., Horton, S., & Penny, D. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000251123.70632.4e · Cited by 68 · see citing works
“A LCOS is common early after cardiac surgery in infants and children and is an important risk factor for poor outcome (47).”
BackgroundChaturvedi, R., Lincoln, C., Gothard, J., Scallan, M., White, P., Redington, A., & Shore, D. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70446-5 · Cited by 68
Relation between oxygen consumption and oxygen delivery in patients after cardiac surgery.
Routsi, C., Vincent, J.-L., Bakker, J., Backer, D. D., Lejeune, P., d'Hollander, A. A., Clerc, J.-L. L., & Kahn, R. J. (1993) · Anesthesia and Analgesia · doi:10.1213/00000539-199312000-00004 · Cited by 65
A Population Pharmacokinetic Analysis of Milrinone in Pediatric Patients After Cardiac Surgery
Bailey, J., Hoffman, T., Wessel, D., Nelson, D., Atz, A., Chang, A. C., Kulik, T., Spray, T., Akbary, A., Miller, R. P., et al. (2004) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1023/b:jopa.0000029488.45177.48 · Cited by 64 · see citing works
“The objectives of this analysis were (1) to determine the best population pharmacokinetic model for milrinone in pediatric patients using the study dose regimen and (2) to determine whether the covariates of weight, age, hepatic function, and renal function, influenced drug disposition.”
BackgroundMethodInfluentialAfterload reduction and cardiac ouptut in infants early after intracardiac surgery.
Appelbaum, A., Blackstone, E., Kouchoukos, N., & Kirklin, J. (1977) · American Journal of Cardiology · doi:10.1016/s0002-9149(77)80103-3 · Cited by 62 · see citing works
Self-citationEarly risks of open heart surgery for mitral valve disease.
Appelbaum, A., Kouchoukos, N., Blackstone, E., & Kirklin, J. (1976) · American Journal of Cardiology · doi:10.1016/0002-9149(76)90313-1 · Cited by 60
Self-citationIntraaortic balloon pumping in children.
Pollock, J., Charlton, M., Williams, W. G., Edmonds, J., & Trusler, G. (1980) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)61697-9 · Cited by 58
Burrows, F. A., Williams, W. G., Teoh, K., Wood, A., Burns, J., Edmonds, J., Barker, G., Trusler, G., & Weisel, R. (1988) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)35207-9 · Cited by 54 · see citing works
Hemodynamic Effects of Vasodilator Agents in Dogs with Experimental Ventricular Septal Defects
Synhorst, D., Lauer, R. M., Doty, D. B., & Brody, M. J. (1976) · Circulation · doi:10.1161/01.cir.54.3.472 · Cited by 51
What’s new in pediatric intensive care
Carcillo, J. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000232492.44019.e6 · Cited by 46
“Plasma exchange is equally effective in children with disseminated intravascular coagulation, thrombotic thrombocytopenia purpura, or liver failure coagulopathies (20).”
BackgroundCritical care in cardiovascular medicine
Ravishankar, C., Tabbutt, S., & Wernovsky, G. (2003) · Current Opinion in Pediatrics · doi:10.1097/00008480-200310000-00001 · Cited by 44 · see citing works
Jain, A., Shroff, S. G., Janicki, J. S., Reddy, H. K., & Weber, K. (1991) · doi:10.1378/chest.99.6.1403 · Cited by 44
Continuous monitoring of mixed venous oxygen saturation during aortic surgery.
Shenaq, S., Casar, G., Chelly, J., Ott, H., & Crawford, E. (1987) · Chest · doi:10.1378/chest.92.5.796 · Cited by 41
Acute hepatic failure following cardiac operation in children.
Jenkins, J., Lynn, A., Wood, A., Trusler, G., & Barker, G. (1982) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)38937-8 · Cited by 41
Jarmakani, J., Nakazawa, M., Isabel-jones, J., & Marks, R. (1976) · Circulation · doi:10.1161/01.cir.53.3.555 · Cited by 40 · see citing works
Miletic, K. G., Spiering, T. J., Delius, R. E., Walters, H. L., & Mastropietro, C. W. (2015) · Interactive CardioVascular and Thoracic Surgery · doi:10.1093/icvts/ivu409 · Cited by 40 · see citing works
Effect of Open-Heart Surgery on the Body Composition of Infants and Young Children
Brans, Y., Dweck, H. S., Harris, H., Parr, G., Bailey, P. E., Kirklin, J., & Cassady, G. (1981) · Pediatric Research · doi:10.1203/00006450-198107000-00009 · Cited by 39
Self-citationFirst experiences with intraoperative Levosimendan in pediatric cardiac surgery
Osthaus, W. A., Boethig, D., Winterhalter, M., Huber, D., Goerler, H., Sasse, M., & Sümpelmann, R. (2009) · European Journal of Pediatrics · doi:10.1007/s00431-008-0834-7 · Cited by 38 · see citing works
Sumimoto, T., Takayama, Y., Iwasaka, T., Sugiura, T., Takeuchi, M., Hasegawa, T., Tarumi, N., Takashima, H., Nakamura, S., Taniguchi, H., et al. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90754-6 · Cited by 38
Hill, K. D., Baldwin, H. S., Bichel, D. P., Butts, R. J., Chamberlain, R. C., Ellis, A. M., Graham, E. M., Hickerson, J., Hornik, C. P. V., Jacobs, J. P., et al. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.11.016 · Cited by 44 · see citing works
Hummel, J., Rücker, G., & Stiller, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011312.pub3 · Cited by 40 · see citing works
Duggal, B., Pratap, U., Slavík, Z., Kaplanová, J., & Macrae, D. (2005) · Pediatric Cardiology · doi:10.1007/s00246-005-0881-z · Cited by 36 · see citing works
“The incidence of low cardiac output syndrome (LCOS) as one of these complications at a single institution remained approximately 25% despite change in the spectrum of treated defects and patients age throughout the years [17, 25].”
BackgroundSchlichtig, R., Cowden, W., & Chaitman, B. (1986) · American Journal of Medicine · doi:10.1016/0002-9343(86)90621-2 · Cited by 36
Bhalala, U., Nishisaki, A., McQueen, D., Bird, G. L., Morrison, W., Nadkarni, V., Nathan, M., & Starr, J. (2012) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3182389531 · Cited by 35 · see citing works
“Apredictable fall in cardiac output (CO), referred to as low cardiac output (LCO) syndrome, occurs after congenital heart surgery and is one of the major causes of perioperative morbidity and mortality (1, 2).”
BackgroundManagement of the cardiovascular subsystem after cardiac surgery.
Kirklin, J., & Kirklin, J. (1981) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)61060-0 · Cited by 35
Self-citationLi, J., Hoschtitzky, A., Allen, M., Elliott, M., & Redington, A. (2004) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2004.02.032 · Cited by 33
Management of the postoperative cardiovascular surgical patient.
Kouchoukos, N., & Karp, R. B. (1976) · American Heart Journal · doi:10.1016/s0002-8703(76)80053-1 · Cited by 33
A Review of Tetralogy of Fallot and Postoperative Management
Forman, J., Beech, R., Slugantz, L., & Donnellan, A. (2019) · Critical Care Nursing Clinics of North America · doi:10.1016/j.cnc.2019.05.003 · Cited by 36 · see citing works
Suemori, T., Skowno, J., Horton, S., Bottrell, S., Butt, W., & Davidson, A. J. (2016) · Paediatric anaesthesia · doi:10.1111/pan.12800 · Cited by 32 · see citing works
Goal-Directed Management of Pediatric Shock in the Emergency Department
Carcillo, J., Kato, H., Lin, J. C., & Orr, R. (2007) · Clinical Pediatric Emergency Medicine · doi:10.1016/j.cpem.2007.07.002 · Cited by 32 · see citing works
“Therefore, Han et al [6] and Orr and colleagues [7] examined early goal-directed therapy for neonatal and pediatric septic shock and “all-comer” shock in community hospital emergency departments, using prolonged capillary refill of longer than 2 seconds as a surrogate marker of decreased CO according to the report rec…”
MethodResultInfluentialOxygen transport in critically ill infants after congenital heart operations.
Rossi, A., Seiden, H., Gross, R. P., & Griepp, R. B. (1999) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(98)01255-7 · Cited by 31
Inomata, S., Nishikawa, T., & Taguchi, M. (1994) · British Journal of Anaesthesia · doi:10.1093/bja/72.1.11 · Cited by 30 · see citing works
“Intermittent or continuous measurement of mixed venous oxygen saturation (SvOt) has been reported to be a useful indicator of alterations in cardiac output (CO) and oxygen consumption (Vot) and serious complications in cardiovascular surgery and critically ill patients [1-15].”
BackgroundHyperlactatemia: An Update on Postoperative Lactate
Stephens, E. H., Epting, C. L., Backer, C. L., & Wald, E. (2020) · World Journal for Pediatric and Congenital Heart Surgery · doi:10.1177/2150135120903977 · Cited by 28 · see citing works
Flechet, M., Güiza, F., Vlasselaers, D., Desmet, L., Lamote, S., Delrue, H., Beckers, M., Casaer, M., Wouters, P., den Berghe, G. V., et al. (2018) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001495 · Cited by 28
“Inadequate tissue perfusion and oxygenation are often associated with poor prognosis (5).”
BackgroundPreoperative assessment of high-risk surgical patients.
Savino, J., & del Guercio, L. (1985) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)43681-9 · Cited by 27
Measurement of cardiac output by thermodilution in infants and children after open-heart operations.
Mathur, M., Harris, E., Yarrow, S., & Barratt-boyes, B. (1976) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)40441-8 · Cited by 27
Amiet, V., Perez, M., Longchamp, D., Ksontini, T. B., Natterer, J., Plaza-Wüthrich, S., Cotting, J., & Bernardo, S. D. (2017) · Pediatric Cardiology · doi:10.1007/s00246-017-1718-2 · Cited by 27 · see citing works
Davidson, J. A., Khailova, L. S., Treece, A. L., Robison, J., Soranno, D. E., Jaggers, J. J., Ing, R. J., Lawson, S., & Lujan, S. M. O. (2019) · Scientific Reports · doi:10.1038/s41598-019-50481-w · Cited by 27 · see citing works
Recent developments in the perioperative management of the paediatric cardiac patient
Stocker, C. F., & Shekerdemian, L. S. (2006) · Current Opinion in Anaesthesiology · doi:10.1097/01.aco.0000236135.77733.cd · Cited by 30 · see citing works
Nitroprusside and epinephrine for treatment of low output in children after open-heart surgery.
Benzing, G., Helmsworth, J. A., Schreiber, J., & Kaplan, S. (1979) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)63363-2 · Cited by 26 · see citing works
Rogers, L., Ray, S., Johnson, M. K. A., Feinstein, Y., Dominguez, T. E., Peters, M. J., Hoskote, A. U., & Brown, K. (2019) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001960 · Cited by 29 · see citing works
Berner, M., Rouge, J., & Friedli, B. (1983) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)61078-8 · Cited by 25
Alternatives to Swan-Ganz cardiac output monitoring.
Moore, F., Haenel, J., & Moore, E. E. (1991) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)45481-2 · Cited by 24 · see citing works
Postoperative Abdominal NIRS Values Predict Low Cardiac Output Syndrome in Neonates
Hickok, R. L., Spaeder, M., Berger, J., Schuette, J., & Klugman, D. (2016) · World journal for pediatric & congenital heart surgery · doi:10.1177/2150135115618939 · Cited by 23 · see citing works
Kim, J.-W., Gwak, M., Shin, W., Kim, H.-J., Yu, J. J., & Park, P.-H. (2014) · Pediatric Cardiology · doi:10.1007/s00246-014-1046-8 · Cited by 28 · see citing works
Gastrointestinal complications associated with the surgical treatment of heart disease in children
Ferguson, L., Gandiya, T., Kaselas, C., Sheth, J., Hasan, A., & Gabra, H. O. S. (2016) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2016.10.052 · Cited by 24 · see citing works
Postoperative management of heart failure in pediatric patients
Yuerek, M., Rossano, J. W., Mascio, C. E., & Shaddy, R. E. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2016.1117388 · Cited by 24 · see citing works
“occurring 9–12 h after CPB.[8,10] With appropriate intensive care management of LCOS morbidity or need for mechanical circulatory support (MCS) can be”
BackgroundMethodInfluentialMultiple organ system extracorporeal support in critically ill children.
Carcillo, J. (2008) · The Pediatric clinics of North America · doi:10.1016/j.pcl.2008.03.002 · Cited by 21
Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation
Joynt, C., Bigam, D., Charrois, G., Jewell, L., Korbutt, G., & Cheung, P. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1060-5 · Cited by 21 · see citing works
Summary Proceedings From the Cardiology Group on Postoperative Cardiac Dysfunction
Roth, S., Adatia, I., & Pearson, G. (2006) · Pediatrics · doi:10.1542/peds.2005-0620g · Cited by 21
da Silveira, D. B. C., Wender, O., & Azambuja, P. C. (2007) · doi:10.1590/s0102-76382007000300002 · Cited by 20
Noninvasive hemodynamic monitoring of septic shock in children
Fathi, E. M., Narchı, H., & Chedid, F. D. (2018) · World Journal of Methodology · doi:10.5662/wjm.v8.i1.1 · Cited by 22 · see citing works
Does near-infrared spectroscopy play a role in paediatric intensive care?
Desmond, F., & Namachivayam, S. (2016) · doi:10.1093/bjaed/mkv053 · Cited by 19
Sepsis in Pediatric Cardiac Intensive Care
Wheeler, D., & Wong, H. (2016) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000796 · Cited by 19 · see citing works
Lemson, J., Driessen, J., & van der Hoeven, J. G. (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1252-z · Cited by 19
“Following complex congenital cardiac surgery, a certain number of patients suffer from a low cardiac output syndrome leading to a distorted balance between oxygen delivery (DO2) and oxygen consumption (VO2) [1].”
BackgroundInfluentialAnderson, R., Smith, A. U., & Cook, A. (2004) · Cardiology in the Young · doi:10.1017/s1047951104006249 · Cited by 19
Moodie, D., Feldt, R. H., Kaye, M. P., Strelow, D., & van der Hagen, L. J. (1978) · Journal of Surgical Research · doi:10.1016/0022-4804(78)90123-3 · Cited by 18
Objective Assessment of Cardiac Output in Infants after Cardiac Surgery
BOHN, D. J. (2011) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2011.01.002 · Cited by 20 · see citing works
Cardiac decompression after operation for congenital heart disease in infancy.
Elami, A., Permut, L., Laks, H., Drinkwater, D., & Sebastian, J. (1994) · Annals of Thoracic Surgery · doi:10.1016/0003-4975(94)91921-6 · Cited by 17
Jaccard, C., Berner, M., Rouge, J., Oberhänsli, I., & Friedli, B. (1984) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)38413-2 · Cited by 17 · see citing works
Flick, R., Sprung, J., Gleich, S. J., Barnes, R. D., Warner, D., Dearani, J., Scott, P. D., Hanson, A., Schroeder, D., & Schears, G. (2008) · Paediatric anaesthesia · doi:10.1111/j.1460-9592.2008.02632.x · Cited by 16
Pharmacologic support for postoperative low cardiac output.
Disesa, V. (1991) · Seminars in Thoracic and Cardiovascular Surgery · doi:10.5555/uri:pii:104306799190049d · Cited by 16
Pulmonary artery catheterization in pediatric intensive care.
Katz, R., Pollack, M. M., & Weibley, R. (1983) · Advances in Pediatrics · doi:10.1016/s0065-3101(22)00578-3 · Cited by 16
The Evolution of Pediatric Cardiac Critical Care
Checchia, P. A., Brown, K., Wernovsky, G., Penny, D. J., & Bronicki, R. A. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000004832 · Cited by 22 · see citing works
Bhalala, U. S., Appachi, E., & Mumtaz, M. A. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00104 · Cited by 14 · see citing works
Myocardial Oxidative Stress in Infants Undergoing Cardiac Surgery
Sznycer-Taub, N. R., Mackie, S. A., Peng, Y.-W., Donohue, J. E., Yu, S., Aiyagari, R., & Charpie, J. (2016) · Pediatric Cardiology · doi:10.1007/s00246-016-1345-3 · Cited by 15 · see citing works
Carcillo, J. (2012) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3182231667 · Cited by 15 · see citing works
“In a series of classic studies, Parr, Kirklin, Pacifico, and others (3, 4) evaluated risk factors for sudden cardiac death after cardiac surgery in infants.”
BackgroundAn International Survey of Corticosteroid Use for the Management of Low Cardiac Output Syndrome
Flores, S., Fitzgerald, M., Iliopoulos, I. D., Daily, J., Rodriguez, M., Nelson, D., Wong, H., Menon, K., & Cooper, D. (2017) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001180 · Cited by 14 · see citing works
A technique for placement of left atrial monitoring line.
McNicholas, K., & Niguidula, F. N. (1983) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)60439-0 · Cited by 14
Anesthesia and postoperative care for cardiac operations.
Tarhan, S., White, R. D., & Moffitt, E. (1977) · Annals of Thoracic Surgery · doi:10.1016/s0003-4975(10)64096-9 · Cited by 14
Oxygen consumption following pediatric cardiac surgery.
Puhakka, K., Räsänen, J., Leijala, M., & Peltola, K. (1994) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1016/1053-0770(94)90195-3 · Cited by 13
Non-invasive Cardiac Output Monitoring in Congenital Heart Disease
Tandon, A., Bhattacharya, S., Morca, A., Inan, O. T., Munther, D. S., Ryan, S. D., Latifi, S. Q., Lu, N., Lasa, J. J., Marino, B. S., et al. (2023) · Current Treatment Options in Pediatrics · doi:10.1007/s40746-023-00274-1 · Cited by 12 · see citing works
Benson, E. J., Aronowitz, D., Forti, R., Lafontant, A., Ranieri, N. R., Starr, J. P., Melchior, R. W., Lewis, A., Jahnavi, J., Breimann, J., et al. (2023) · Metabolites · doi:10.3390/metabo13111153 · Cited by 12
“…and excessive oxygen delivery relative to oxygen demand during CPB have been identified as potential risk factors for neurological injury [1,8,9], and dynamic changes in cerebral physiology and neurological injury biomarkers have also been observed over the first 24 h after bypass [10–12].”
BackgroundJothinath, K., Balakrishnan, S., Raju, V., Menon, S., & Osborn, J. (2021) · Annals of Cardiac Anaesthesia · doi:10.4103/aca.aca_160_19 · Cited by 18 · see citing works
“It was first defined in the pediatric population by Parr and colleagues in 1975 using the dye dilution technique.[1] Early recognition and treatment of LCOS is paramount due to its adverse impact on perioperative morbidity and mortality.”
MethodThe use of balloon-tipped pulmonary artery catheters in children undergoing cardiac surgery
Damen, J., & Wever, J. (2004) · Intensive Care Medicine · doi:10.1007/bf00265116 · Cited by 12
Sun, Y., & Yao, Y.-T. (2022) · Journal of Cardiac Surgery · doi:10.1111/jocs.16914 · Cited by 15 · see citing works
“As low cardiac output develops, patients are at higher risk of morbidity in the postoperative period.(2,3) Although significant technological advances have improved outcomes in pediatric cardiac surgery patients,(4,5) managing these patients relies on multiple strategies to mitigate the potential threat of low cardiac…”
BackgroundHeart Failure Treatment in the Intensive Care Unit in Children
Jefferies, J. L., Hoffman, T. M., & Nelson, D. P. (2010) · Heart Failure Clinics · doi:10.1016/j.hfc.2010.06.001 · Cited by 15 · see citing works
- Authors
- Parr, G. V., Blackstone, E. H., & Kirklin, J. W.
- Affiliations
- University of Alabama at Birmingham (US)
- Blackstone (United States) (US)
- ORCID
- Blackstone, E H
- Venue
- Circulation
- Published
- 1975-05
- Volume
- 51
- Issue
- 5
- Pages
- 867-874
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2001400624
- Cited by
- 210
- References
- 0
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 1 · 2023: 10 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 12 · 2016: 11 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- cardiac index, mortality, acute heart failure, systemic vascular resistance, cardiac output, infants, congenital heart disease, postoperative complications, left ventricular afterload, hemodynamic monitoring, mortality prediction
- MeSH terms
- Blood, Blood Pressure, Body Surface Area, Carbon Dioxide, Cardiac Output, Cardiopulmonary Bypass, Child, Preschool, Heart Arrest, Heart Defects, Congenital, Cardiac Surgical Procedures, Hemoglobins, Humans, Hydrogen-Ion Concentration, Hypothermia, Induced, Infant, Infant, Newborn, Oxygen, Oxygen Consumption, Postoperative Care, Postoperative Complications, Pulmonary Artery, Pulmonary Edema, Time Factors, Vascular Resistance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
