The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Natural history of chronic second-degree atrioventricular nodal block
Abstract
This report details our experience with documented chronic second-degree atrioventricular (AV) nodal block (proximal to His [H]) in 56 patients. Forty-six men (82%) and 10 women (18%), ages 18-87 years, were studied. Nineteen of the patients (34%) had no organic heart disease (including seven trained athletes) and 37 (66%) had organic heart disease. ECGs in all patients demonstrated episodes of type I second-degree block; five patients also had periods of 2:1 block. Prospective follow-up patients with no organic heart disease (157-2280 days, mean 1395 +/- 636 days) revealed one patient with clear indication for permanent pacing because of bradyarrhythmic symptoms (permanently placed on day 220 of follow-up). Two patients died nonsuddenly. In patients with organic heart disease (prospective follow-up of 60-2950 days, mean 1347 +/- 825 days), pacemakers were implanted in 10 patients, primarily for treatment of congestive heart failure in eight and syncope in two. Sixteen patients died -- three suddenly, seven with congestive heart failure, two of an acute myocardial infarction and four of causes unrelated to cardiac disease. In summary, chronic second-degree AV nodal block has a relatively benign course in patients without organic heart disease. In patients with organic heart disease, prognosis is poor and related to the severity of underlying heart disease.
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“In asymptomatic patients with PR prolongation alone, Mobitz type I second degree AV block, or 2:1 block at the AV nodal level, the clinical course is generally benign, with a low rate of progression to complete AV block [16] .”
From Evaluating and managing bradycardia (2020) · cites this paper as [16]
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Cites
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Self-citationThe conduction system in cardiac amyloidosis
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Self-citationWenckebach A-V block: A frequent feature following heavy physical training
Meytes, I., Kaplinsky, E., Yahini, J. H., Hanne-Paparo, N., & Neufeld, H. N. (1975) · American Heart Journal · doi:10.1016/0002-8703(75)90421-4 · Cited by 134
Medical and physiological considerations in the use of artificial cardiac pacing. Part I
McNally, E. M., & Benchimol, A. (1968) · American Heart Journal · doi:10.1016/0002-8703(68)90096-3 · Cited by 93
Electrocardiographic findings in 67,375 asymptomatic subjects
Johnson, R. L., Averill, K. H., & Lamb, L. E. (1960) · The American Journal of Cardiology · doi:10.1016/0002-9149(60)90044-8 · Cited by 87
Sinus nodal responses to atrial extrastimuli in patients without apparent sinus node disease
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Self-citationThe incidence of typical and atypical A-V Wenckebach periodicity
Denes, P., Levy, L., Pick, A., & Rosen, K. M. (1975) · American Heart Journal · doi:10.1016/0002-8703(75)90005-8 · Cited by 79
Wenckebach atrioventricular block (Mobitz type I) in children and adolescents
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ACC/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities
Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.032 · Cited by 2,546
2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy
Glikson, M., Nielsen, J. C., Kronborg, M. B., Michowitz, Y., Auricchio, A., Barbash, I. M., Barrabés, J. A., Boriani, G., Braunschweig, F., Brignole, M., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab364 · Cited by 2,019
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities
Epstein, A. E., Dimarco, J., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2008) · Circulation · doi:10.1161/circualtionaha.108.189742 · Cited by 1,772
Epstein, A. E., Dimarco, J., Ellenbogen, K. A., Estes, N. A. M., Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., et al. (2012) · Circulation · doi:10.1161/cir.0b013e318276ce9b · Cited by 1,496
Gregoratos, G., Abrams, J., Epstein, A. E., Freedman, R. A., Hayes, D. L., Hlatky, M. A., Kerber, R. E., Naccarelli, G. V., Schoenfeld, M. H., Silka, M. J., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02528-7 · Cited by 1,273
Metadata
- Authors
- Strasberg, B., Amat-Y-Leon, F., Dhingra, R. C., Palileo, E., Swiryn, S., Bauernfeind, R., Wyndham, C., & Rosen, K. M.
- Affiliations
- Bauerfeind (Germany) (DE)
- Venue
- Circulation
- Published
- 1981-05
- Volume
- 63
- Issue
- 5
- Pages
- 1043-1049
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1993507703
- Cited by
- 132
- References
- 20
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 8
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- second-degree atrioventricular block, organic heart disease, pacemaker implantation, congestive heart failure, syncope, sudden cardiac death, prognosis, natural history (disease), athletes
- MeSH terms
- Adolescent, Adult, Aged, Chronic Disease, Electrocardiography, Electrophysiology, Female, Heart Block, Heart Diseases, Humans, Male, Middle Aged, Pacemaker, Artificial, Syncope, Radiography, Thoracic
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Cite CoChat for the checks on this page, and the paper for its own findings.
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- CoChat. (2026). Citation check: Natural history of chronic second-degree atrioventricular nodal block. https://app.cochat.ai/papers/10.1161/01.cir.63.5.1043
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- Strasberg, B., Amat-Y-Leon, F., Dhingra, R. C., Palileo, E., Swiryn, S., Bauernfeind, R., Wyndham, C., & Rosen, K. M. (1981). Natural history of chronic second-degree atrioventricular nodal block. Circulation. https://doi.org/10.1161/01.cir.63.5.1043
