The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Aggravation and provocation of ventricular arrhythmias by antiarrhythmic drugs.
Open accessAbstract
Antiarrhythmic drugs may aggravate or even induce ventricular arrhythmias. This type of adverse reaction is becoming more prevalent as the use of antiarrhythmic agents becomes more widespread. In a retrospective analysis of antiarrhythmic drug action, a worsening of arrhythmia was observed in 80 of 722 (11.1%) antiarrhythmic drug tests in 53 of 155 patients being treated for ventricular tachyarrhythmias. Aggravation of arrhythmias was defined by occurrence of a fourfold increase in the frequency of ventricular premature complexes, a 10-fold increase in repetitive forms, or the first emergence of sustained ventricular tachycardia coincident with time course of action of the particular drug under study. Such aggravation was noted with each of nine drugs tested: quinidine, procainamide, disopyramide, propranolol, metoprolol, aprindine, mexiletine, tocainide and pindolol. The frequency of this complication for a specific drug ranged from 5.9-15.8%. Blood drug concentrations were consistently in the therapeutic range. A study of the variability of ventricular arrhythmia during 48-hour Holter monitoring and exercise stress testing in no instance showed arrhythmia enhancement commensurate with that defining aggravation. Our data suggest that this potentially serious complication is not readily predictable and requires a systematic approach to antiarrhythmic drug testing before a patient is prescribed a long-range maintenance program.
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Citations
Cites
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Self-citationManagement of patients with malignant ventricular arrhythmias
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THE PHYSIOLOGICAL DISPOSITION AND CARDIAC EFFECTS OF PROCAINE AMIDE
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Cited by
Drug-induced prolongation of the QT interval
Roden, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032426 · Cited by 1,965
Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.178233 · Cited by 1,080
Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation
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Long-Term Follow-up of Asymptomatic Healthy Subjects with Frequent and Complex Ventricular Ectopy
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Proarrhythmia, cardiac arrest and death in young patients receiving encainide and flecainide
Fish, F. A., Gillette, P. C., & Benson, D. W. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90586-x · Cited by 193
Metadata
- Authors
- Velebit, V, Podrid, P., Lown, B., Cohen, B. H., & Graboys, T. B.
- Venue
- Circulation
- Published
- 1982-05
- Volume
- 65
- Issue
- 5
- Pages
- 886-894
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2014562798
- Cited by
- 632
- References
- 15
- FWCI
- 50.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Velebit, V, Podrid, P., Lown, B., Cohen, B. H., & Graboys, T. B. (1982). Aggravation and provocation of ventricular arrhythmias by antiarrhythmic drugs. Circulation. https://doi.org/10.1161/01.cir.65.5.886
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