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Cited by 657

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate.

Open access
Rodeheffer, R J, Gerstenblith, G, Becker, L C, Fleg, J L, Weisfeldt, M L, Lakatta, E G·1984·Circulation
DOI 10.1161/01.cir.69.2.203
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Abstract

To assess the effect of age on cardiac volumes and function in the absence of overt or occult coronary disease, we performed serial gated blood pool scans at rest and during progressive upright bicycle exercise to exhaustion in 61 participants in the Baltimore Longitudinal Study of Aging. The subjects ranged in age from 25 to 79 years and were free of cardiac disease according to their histories and results of physical, resting and stress electrocardiographic, and stress thallium scintigraphic examinations. Absolute left ventricular volumes were obtained at each workload. There were no age-related changes in cardiac output, end-diastolic or end-systolic volumes, or ejection fraction at rest. During vigorous exercise (125 W), cardiac output was not related to age (cardiac output [1/min] = 16.02 + 0.03 [age]; r = .12, p = .46). However, there was an age-related increase in end-diastolic volume (end-diastolic volume [ml] = 86.30 + 1.48 [age]; r = .47, p = .003) and stroke volume (stroke volume [ml] = 85.52 + 0.80 [age]; r = .37, p = .02), and an age-related decrease in heart rate (heart rate [beats/min] = 184.66 - 0.70 [age]; r = -.50, p = .002). The dependence of the age-related increase in stroke volume on diastolic filling was emphasized by the fact that at this high workload end-systolic volume was higher (end-systolic volume [ml] = 3.09 + 0.65 [age]; r = .45, p = .003) and ejection fraction lower (ejection fraction = 88.48 - 0.18 [age]; r = -.33, p = .04) with increasing age. These findings indicate that although aging does not limit cardiac output per se in healthy community-dwelling subjects, the hemodynamic profile accompanying exercise is altered by age and can be explained by an age-related diminution in the cardiovascular response to beta-adrenergic stimulation.

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Metadata

Authors
Rodeheffer, R. J., Gerstenblith, G., Becker, L. C., Fleg, J. L., Weisfeldt, M. L., & Lakatta, E. G.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1984-02
Volume
69
Issue
2
Pages
203-213
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.69.2.203
OpenAlex
W2012464391
Cited by
657
References
1
FWCI
61.17
Type
journal article
Language
en
Open access
bronze

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