Influence of sex hormones and phytoestrogens on heart disease in men and women

Bhupathy, Poornima; Haines, Christopher Dean; Leinwand, Leslie Anne

doi:10.2217/whe.09.80

Cited by 125Phytoestrogen effects and researchMenopause: Health Impacts and TreatmentsEstrogen and related hormone effects

Influence of sex hormones and phytoestrogens on heart disease in men and women

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Bhupathy, Poornima, Haines, Christopher Dean, Leinwand, Leslie Anne·2010·Women s Health

DOI 10.2217/whe.09.80PMC PMC2836937

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Abstract

Cardiovascular disease (CVD) is the number one cause of morbidity and mortality in men and women worldwide. According to the WHO, by 2015, almost 20 million people will die from CVD each year. It is well established that men and women differ not only in baseline cardiac parameters, but also in the clinical presentation, diagnosis and treatment outcomes of CVD. Women tend to develop heart disease later in life than men. This difference has been attributed to the loss of estrogen during the menopausal transition; however, the biological explanations for the sexual dimorphism in CVD are more complex and seem unlikely to be due to estrogen alone. The current controversy that has arisen regarding the effects of HRT on CVD in women is a case in point. In this review, the sex-based differences in cardiac (patho-) physiology are discussed with emphasis on the impact of sex hormones, hormone receptors and diet on heart disease.

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Sex hormones are thought to play an important role in the development of cardiovascular diseases.
“Likewise, sex hormones are thought to play an important role in the development of cardiovascular diseases [19–21].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [20]

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[181]Setchell KD Brown NM Lydeking-Olsen E The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones J Nutr 132 3577 3584 2002 12468591

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Authors: Bhupathy, P., Haines, C. D., & Leinwand, L. A.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Bhupathy, Poornima
Haines, Christopher Dean
Leinwand, Leslie Anne
ORCID: Leinwand, Leslie Anne
Venue: Women s Health
Publisher: SAGE Publications
Published: 2010-01
Volume: 6
Issue: 1
Pages: 77-95
ISSN: 1745-5057 (ISSN-L)
1745-5065
DOI: 10.2217/whe.09.80
PMC: PMC2836937
OpenAlex: W2099284230
Cited by: 125
References: 191
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 17 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 6 · 2013: 8 · 2012: 10
FWCI: 1.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Women s Health (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL050560)
National Institute of General Medical Sciences (T32GM008759, T32GM142607)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: sex hormones, phytoestrogens, cardiovascular disease, sex differences, estrogen, menopause, hormone replacement therapy, hormone receptors, diet, heart disease in women
MeSH terms: Age Factors, Animals, Cardiovascular Diseases, Female, Heart, Humans, Male, Sex Factors, Gonadal Steroid Hormones, Estrogen Replacement Therapy, Phytoestrogens, Mice

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Influence of sex hormones and phytoestrogens on heart disease in men and women

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