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Arteriovenous carbon dioxide and pH gradients during cardiac arrest.
Open accessAbstract
In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis due to lactic acidosis predominates during the initial 8 min of cardiopulmonary resuscitation. Arterial blood gases fail as indicators of systemic acid-base status and therefore as indicators of tissue acidosis.
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Citations
Cited by
End-Tidal Carbon Dioxide Concentration during Cardiopulmonary Resuscitation
Falk, J. L., Rackow, E. C., & Weil, M. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803103181005 · Cited by 466
Self-citationAcute mesenteric ischemia: Pathophysiology, diagnosis, and treatment
Benjamin, E., & Oropello, J. M. (1993) · Disease-a-Month · doi:10.1016/0011-5029(93)90023-v · Cited by 150
Nitric Oxide-Releasing Xerogel-Based Fiber-Optic pH Sensors
Dobmeier, K. P., Charville, G. W., & Schoenfisch, M. H. (2006) · Analytical Chemistry · doi:10.1021/ac060995p · Cited by 22
Metadata
- Authors
- Grundler, W., Weil, M. H., & Rackow, E. C.
- Venue
- Circulation
- Published
- 1986-11
- Volume
- 74
- Issue
- 5
- Pages
- 1071-1074
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2029707988
- Cited by
- 188
- References
- 0
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Arteriovenous carbon dioxide and pH gradients during cardiac arrest. https://app.cochat.ai/papers/10.1161/01.cir.74.5.1071
- The paper
- Grundler, W., Weil, M. H., & Rackow, E. C. (1986). Arteriovenous carbon dioxide and pH gradients during cardiac arrest. Circulation. https://doi.org/10.1161/01.cir.74.5.1071
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.