Nitric Oxide-Releasing Xerogel-Based Fiber-Optic pH Sensors
Open accessAbstract
A xerogel-based optical pH sensor capable of releasing low levels of nitric oxide (NO) and measuring changes in solution pH is reported. Through simple dip-coating procedures, aminoalkoxysilane-based xerogel films modified with N-diazeniumdiolate NO donor precursors and the fluorescent pH indicator seminaphthorhodamine-1 carboxylate (SNARF-1) were sequentially deposited onto optical fibers. The resulting sensors were characterized by fast and linear response to pH throughout the physiological range (pH 7.0-7.8). Real-time chemiluminescence measurements confirmed that the presence of the overlying SNARF-1-containing TMOS layer did not have an inhibitory effect on N-diazeniumdiolate formation or NO release, and the NO-releasing coatings were capable of maintaining NO fluxes >0.4 pmol/cm(2) s up to 16 h. In vitro blood compatibility studies using porcine platelets confirmed the expected thromboresistivity of the NO-releasing xerogel coatings.
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NO releasing intravascular glucose, pH, and CO2 sensors using diazeniumdiolated NO donors demonstrated much improved electrochemical responses over corresponding control sensors.
“Similar to oxygen sensors, NO releasing intravascular glucose,271–275 pH,275,276 and CO2275,277 sensors using diazeniumdiolated NO donors have also been tested, demonstrating much improved electrochemical responses over the corresponding control sensors.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [276]
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- Authors
- Dobmeier, K. P., Charville, G. W., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-10-07
- Volume
- 78
- Issue
- 21
- Pages
- 7461-7466
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- PMC
- PMC2564808
- OpenAlex
- W1968712331
- Cited by
- 22
- References
- 49
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Analytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Science Foundation
- Frances C. and William P. Smallwood Foundation
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
- Topics
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Fiber Optic Sensors
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- nitric oxide release, fiber optic pH sensor, optical pH sensing, SNARF-1, dip coating, chemiluminescence, platelet aggregation, hemocompatibility
- MeSH terms
- Animals, Benzopyrans, Blood Platelets, Cell Adhesion, Fiber Optic Technology, Fluorescent Dyes, Gels, Hydrogen-Ion Concentration, Microscopy, Electron, Scanning, Naphthols, Nitric Oxide, Rhodamines, Sensitivity and Specificity, Swine, Reproducibility of Results, Optical Fibers
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