Cited by 160Advanced Drug Delivery Systemsbiodegradable polymer synthesis and propertiesTissue Engineering and Regenerative Medicine

Rapidly Self-Expandable Polymeric Stents with a Shape-Memory Property

Chen, Mei-Chin, Tsai, Hung-Wen, Chang, Yen, Lai, Wei-Yun, Mi, Fwu-Long, Liu, Chin-Tang, Wong, Hen-Sheng, Sung, Hsing-Wen·2007·Biomacromolecules

Abstract

A novel biodegradable stent, made of chitosan films cross-linked with an epoxy compound, with a shape-memory property was developed. To reduce their crystallinity, glycerol and poly(ethylene oxide) were blended in the chitosan films. The mechanical properties of the prepared stent were studied using a commercially available metallic stent as a control. After blending, the ductility of the chitosan films was improved, and the compressive strength of the stent was significantly enhanced. The metallic stent could tolerate elastic deformations of 10% before becoming irreversibly deformed, while the polymeric stent was able to withstand deformations up to 30% and still regain its original configuration. The developed stent could rapidly expand ( approximately 150 s) from its crimped (temporary) to fully expanded (permanent) states stimulated by hydration, which is advantageous considering avoiding its migration during in vivo deployment. In the preliminary animal study, the implanted stent was found to be intact, and no thrombus formation was seen in the stent-implanted vessel. This degradable stent can be an attractive alternative to metallic stents and may serve as a useful vehicle for local drug delivery.

Integrity signals

Registry

Crossref · 10.1021/bm7004615

Cites

34 of 34 references verified0 citation errors · 0 not checkable

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  • A water sensitive biodegradable stent made of chitosan films crosslinked with an epoxy compound is prepared following this strategy by Chen et al.

    “A water sensitive biodegradable stent made of chitosan films crosslinked with an epoxy compound is prepared following this strategy by Chen et al. [403].”

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Authors
Chen, M.-C., Tsai, H.-W., Chang, Y., Lai, W.-Y., Mi, F.-L., Liu, C.-T., Wong, H.-S., & Sung, H.-W.
Affiliations
National Tsing Hua University (TW)
Venue
Biomacromolecules
Published
2007-08-04
Volume
8
Issue
9
Pages
2774-2780
ISSN
  • 1525-7797 (ISSN-L)
  • 1526-4602
OpenAlex
W2050221459
Cited by
160
References
34
Citations by year
2026: 5 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 12 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 8
FWCI
6.95
Type
journal article
Language
en
Open access
closed
Locations
  • Biomacromolecules (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
chitosan films, epoxy crosslinking, biodegradable stents, crystallinity reduction, ductility, compressive strength, stent migration, thrombus formation, local drug delivery, vascular stents
MeSH terms
Animals, Aorta, Biocompatible Materials, Hydrogen-Ion Concentration, Membranes, Artificial, Polymers, Rabbits, Time Factors, Molecular Structure, Stents, Chitosan

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