Rapidly Self-Expandable Polymeric Stents with a Shape-Memory Property
Abstract
A novel biodegradable stent, made of chitosan films cross-linked with an epoxy compound, with a shape-memory property was developed. To reduce their crystallinity, glycerol and poly(ethylene oxide) were blended in the chitosan films. The mechanical properties of the prepared stent were studied using a commercially available metallic stent as a control. After blending, the ductility of the chitosan films was improved, and the compressive strength of the stent was significantly enhanced. The metallic stent could tolerate elastic deformations of 10% before becoming irreversibly deformed, while the polymeric stent was able to withstand deformations up to 30% and still regain its original configuration. The developed stent could rapidly expand ( approximately 150 s) from its crimped (temporary) to fully expanded (permanent) states stimulated by hydration, which is advantageous considering avoiding its migration during in vivo deployment. In the preliminary animal study, the implanted stent was found to be intact, and no thrombus formation was seen in the stent-implanted vessel. This degradable stent can be an attractive alternative to metallic stents and may serve as a useful vehicle for local drug delivery.
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A water sensitive biodegradable stent made of chitosan films crosslinked with an epoxy compound is prepared following this strategy by Chen et al.
“A water sensitive biodegradable stent made of chitosan films crosslinked with an epoxy compound is prepared following this strategy by Chen et al. [403].”
From A review of stimuli-responsive shape memory polymer composites (2013) · cites this paper as [403]
Cites
Chitosan Chemistry and Pharmaceutical Perspectives
Kumar, M. N. V. R., Müzzarelli, R. A. A., Muzzarelli, C., Sashiwa, H., & Domb, A. J. (2004) · Chemical Reviews · doi:10.1021/cr030441b · Cited by 2,945 · see citing works
Lendlein, A., Kelch, S., Kratz, K., Schulte, J., & Schauer, S. (2002) · Wiley eBooks · doi:10.1002/0471238961.1908011612051404.a01 · Cited by 2,616 · see citing works
Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications
Lendlein, A., & Langer, R. (2002) · Science · doi:10.1126/science.1066102 · Cited by 2,146 · see citing works
Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency
Mao, H., Roy, K., Troung-Le, V. L., Janes, K. A., Lin, K., Wang, Y., August, J. T., & Leong, K. W. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00361-8 · Cited by 1,229 · see citing works
Serruys, P. W., Luijten, H. E., Beatt, K. J., Geuskens, R., de Feyter, P. J., van den Brand, M., Reiber, J. H., ten Katen, H. J., van Es, G. A., & Hugenholtz, P. G. (1988) · Circulation · doi:10.1161/01.cir.77.2.361 · Cited by 931 · see citing works
Initial and 6-Month Results of Biodegradable Poly- l -Lactic Acid Coronary Stents in Humans
Tamai, H., Igaki, K., Kyo, E., Kosuga, K., Kawashima, A., Matsui, S., Komori, H., Tsuji, T., Motohara, S., & Uehata, H. (2000) · Circulation · doi:10.1161/01.cir.102.4.399 · Cited by 807 · see citing works
Synthesis and characterization of chitosan–poly(acrylic acid) nanoparticles
Hu, Y., Jiang, X., Ding, Y., Ge, H., Yuan, Y., & Yang, C. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00071-6 · Cited by 513 · see citing works
Three-Year Follow-up after Implantation of Metallic Coronary-Artery Stents
Kimura, T., Yokoi, H., Nakagawa, Y., Tamura, T., Kaburagi, S., Sawada, Y., Sato, Y., 横井, 博., Hamasaki, N., Nosaka, H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602293340903 · Cited by 505 · see citing works
Lin, Y.-H., Liang, H., Chung, C.-K., Chen, M., & Sung, H. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.011 · Cited by 445 · see citing works
Self-citationCross-Linking Chitosan Nanofibers
Schiffman, J. D., & Schauer, C. L. (2006) · Biomacromolecules · doi:10.1021/bm060804s · Cited by 437 · see citing works
Wood, E. J. (2004) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.2004.494032069994 · Cited by 363 · see citing works
Kolhe, P., & Kannan, R. M. (2002) · Biomacromolecules · doi:10.1021/bm025689+ · Cited by 328 · see citing works
Lysozyme degradation of partially deacetylated chitin, its films and hydrogels
Pangburn, S., Trescony, P. V., & Heller, J. (1982) · Biomaterials · doi:10.1016/0142-9612(82)90043-6 · Cited by 298 · see citing works
Lysozymes: Model Enzymes in Biochemistry and Biology
(1996) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-9225-4 · Cited by 294 · see citing works
Self‐Assembled Shape‐Memory Fibers of Triblock Liquid‐Crystal Polymers
Ahir, S. V., Tajbakhsh, A. R., & Terentjev, E. M. (2006) · Advanced Functional Materials · doi:10.1002/adfm.200500692 · Cited by 271 · see citing works
In vitro evaluation of a chitosan membrane cross-linked with genipin
Mi, F., Tan, Y.-C., Liang, H., et al. (2001) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856201753113051 · Cited by 199 · see citing works
Self-citationBiodegradable stents with elastic memory
Venkatraman, S. S., Tan, L. P., Joso, J. F. D., Boey, Y. C. F., & Wang, X. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.09.002 · Cited by 180 · see citing works
Galactosylated chitosan as a synthetic extracellular matrix for hepatocytes attachment
Park, I., Yang, J., Jeong, H., Bom, H., Harada, I., Akaike, T., Kim, S., & Cho, C. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00108-x · Cited by 162 · see citing works
Coated Stents for the Prevention of Restenosis: Part I
Babapulle, M. N., & Eisenberg, M. J. (2002) · Circulation · doi:10.1161/01.cir.0000038982.49640.70 · Cited by 162 · see citing works
A genipin-crosslinked gelatin membrane as wound-dressing material: in vitro and in vivo studies
Chang, W., Chang, Y., Lai, P.-H., et al. (2003) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856203766652084 · Cited by 153 · see citing works
Self-citationCollapse pressures of biodegradable stents
Venkatraman, S. S., Poh, T. L., Tjong, V., Mak, K. H., & Boey, F. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00640-3 · Cited by 108 · see citing works
Altered coronary flow properties in diffuse coronary artery ectasia
Akyürek, Ö., Berkalp, B., Sayın, T., et al. (2003) · American Heart Journal · doi:10.1067/mhj.2003.48 · Cited by 93 · see citing works
Butler, M. F., Clark, A., & Adams, S. (2006) · Biomacromolecules · doi:10.1021/bm060133y · Cited by 68 · see citing works
Biodegradation of the Copolymeric Polylactide Stent
Hietala, E., Salminen, U., Ståhls, A., Välimaa, T., Maasilta, P. K., Törmälä, P., Nieminen, M. S., & Harjula, A. L. J. (2001) · Journal of Vascular Research · doi:10.1159/000051067 · Cited by 66 · see citing works
Ruygrok, P., & Serruys, P. W. J. C. (1996) · Circulation · doi:10.1161/01.cir.94.5.882 · Cited by 65 · see citing works
Dallan, P. R. M., Moreira, P. D. L., Petinari, L., Malmonge, S. M., Beppu, M. M., Genari, S. C., & Moraes, Â. M. (2006) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30610 · Cited by 45 · see citing works
Chitosan-oxychitin coatings for prosthetic materials
Müzzarelli, R. A. A. (2001) · Carbohydrate Polymers · doi:10.1016/s0144-8617(00)00205-8 · Cited by 44 · see citing works
Nitinol Properties Affecting Uses in Interventional Radiology
Rabkin, D. J., Lang, E. V., & Brophy, D. P. (2000) · Journal of Vascular and Interventional Radiology · doi:10.1016/s1051-0443(07)61428-6 · Cited by 35 · see citing works
Miconazole-loaded 6-oxychitin–chitosan microcapsules
Genta, I., Perugini, P., Modena, T., et al. (2003) · Carbohydrate Polymers · doi:10.1016/s0144-8617(02)00257-6 · Cited by 33 · see citing works
Evaluation of Two Epoxy Ether Compounds for Biocompatible Potential
Lohrr, J. M., Budig, L., Sagartz, J. E., et al. (1992) · Artificial Organs · doi:10.1111/j.1525-1594.1992.tb00563.x · Cited by 32 · see citing works
Matsumoto, Y., Shimokawa, H., Morishige, K., et al. (2002) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200204000-00007 · Cited by 30 · see citing works
Viscoelastic memory and self-expansion of self-reinforced bioabsorbable stents
Välimaa, T., LAAKSOVIRTA, S., Tammela, T. L. J., Laippala, P. J., Talja, M. T., Isotalo, T., Pétas, A., Taari, K., & Törmälä, P. O. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00076-5 · Cited by 26 · see citing works
Stress analysis of a bulk-filled class-V chemical-cured dental composite restoration
Katona, T. R., Winkler, M. M., & Huang, J. (1996) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199608)31:4 · Cited by 14 · see citing works
Glycosynthase-catalysed formation of modified polysaccharide microstructures
Watts, A. G., & Withers, S. G. (2004) · Biochemical Journal · doi:10.1042/bj20040633 · Cited by 8 · see citing works
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A review of stimuli-responsive shape memory polymer composites
Meng, H., & Li, G. (2013) · Polymer · doi:10.1016/j.polymer.2013.02.023 · Cited by 1,190 · see citing works
Mather, P. T., Luo, X., & Rousseau, I. A. (2009) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-082908-145419 · Cited by 911 · see citing works
A review of stimuli-responsive polymers for smart textile applications
Hu, J., Meng, H., Li, G., & Ibekwe, S. I. (2012) · Smart Materials and Structures · doi:10.1088/0964-1726/21/5/053001 · Cited by 639 · see citing works
Multiple and two-way reversible shape memory polymers: Design strategies and applications
Wang, K., Jia, Y.-G., Zhao, C., & Zhu, X. X. (2019) · Progress in Materials Science · doi:10.1016/j.pmatsci.2019.100572 · Cited by 208 · see citing works
Polymer Networks Combining Controlled Drug Release, Biodegradation, and Shape Memory Capability
Neffe, A. T., Hanh, B. D., Steuer, S., & Lendlein, A. (2009) · Advanced Materials · doi:10.1002/adma.200802333 · Cited by 172 · see citing works
Xiao, Y., Zhou, S., Wang, L., & Gong, T. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am100692n · Cited by 153 · see citing works
Neuss, S., Blomenkamp, I., Stainforth, R., Boltersdorf, D., Jansen, M., Butz, N., Perez-Bouza, A., & Knüchel, R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.027 · Cited by 151 · see citing works
Poly(glycerol sebacate urethane)–cellulose nanocomposites with water-active shape-memory effects
Wu, T., Frydrych, M., O’Kelly, K., & Chen, B. (2014) · Biomacromolecules · doi:10.1021/bm500507z · Cited by 126 · see citing works
Lendlein, A., Zotzmann, J., Feng, Y., Alteheld, A., & Kelch, S. (2009) · Biomacromolecules · doi:10.1021/bm900038e · Cited by 115 · see citing works
Kalita, H., & Karak, N. (2013) · Polymers for Advanced Technologies · doi:10.1002/pat.3149 · Cited by 30 · see citing works
- Authors
- Chen, M.-C., Tsai, H.-W., Chang, Y., Lai, W.-Y., Mi, F.-L., Liu, C.-T., Wong, H.-S., & Sung, H.-W.
- Affiliations
- National Tsing Hua University (TW)
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-08-04
- Volume
- 8
- Issue
- 9
- Pages
- 2774-2780
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2050221459
- Cited by
- 160
- References
- 34
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 12 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 8
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- chitosan films, epoxy crosslinking, biodegradable stents, crystallinity reduction, ductility, compressive strength, stent migration, thrombus formation, local drug delivery, vascular stents
- MeSH terms
- Animals, Aorta, Biocompatible Materials, Hydrogen-Ion Concentration, Membranes, Artificial, Polymers, Rabbits, Time Factors, Molecular Structure, Stents, Chitosan
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