The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.
Abstract
Studies in animals have suggested that increases in blood flow result in dilation of large arteries by an endothelium-dependent mechanism. Atherosclerosis can impair endothelium-dependent vasodilation to vasoactive agents. The purpose of this study was to determine whether or not large coronary arteries in humans exhibit dilation with increases in blood flow and to test the hypothesis that this response is impaired in the presence of atherosclerosis. Graded concentrations of adenosine were infused into the distal left anterior descending (LAD) coronary artery to test the dilator response of the proximal LAD to increases in blood flow. The proximal LAD was thereby exposed to changes in blood flow, but not directly to adenosine. Ten patients with angiographically smooth proximal LAD segments (group 1) and seven patients with irregularities in the proximal LAD consistent with mild atherosclerosis (group 2) were studied. Infusions of adenosine throughout the range of 0.022 to 2.2 mg/min into the LAD produced a dose-dependent increase in estimated coronary blood flow and a mean increase of 305 +/- 27% at 2.2 mg/min adenosine. At 2.2 mg/min adenosine, a striking difference (p less than 0.001) occurred between the significant flow-mediated dilation of the proximal LAD observed in group 1 (+13.2 +/- 1.3% from 2.63 +/- 0.16 mm, p less than 0.001), and the lack of dilation in group 2 (+1.8 +/- 1.5% from 3.20 +/- 0.17 mm, p = NS), despite a greater increase in coronary blood flow in group 2 (+387 +/- 29%) than in group 1 (+230 +/- 36%).(ABSTRACT TRUNCATED AT 250 WORDS)
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Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T. L., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,425
Self-citationRole of endothelium in responses of vascular smooth muscle.
Furchgott, R. F. (1983) · Circulation Research · doi:10.1161/01.res.53.5.557 · Cited by 1,949
Flow-induced release of endothelium-derived relaxing factor
Rubanyi, G. M., Romero, J. C., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.6.h1145 · Cited by 1,366
Nabel, E. G., Ganz, P., Gordon, J. B., Alexander, R. W., & Selwyn, A. P. (1988) · Circulation · doi:10.1161/01.cir.77.1.43 · Cited by 555
Self-citationBossaller, C., Habib, G. B., Yamamoto, H., Williams, C., Wells, S., & Henry, P. D. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112779 · Cited by 531
Wilson, R. F., Laughlin, D. E., Ackell, P. H., Chilian, W. M., Holida, M. D., Hartley, C. J., Armstrong, M. L., Marcus, M. L., & White, C. W. (1985) · Circulation · doi:10.1161/01.cir.72.1.82 · Cited by 509
Förstermann, U., Mügge, A., Alheid, U., Haverich, A., & Frölich, J. C. (1988) · Circulation Research · doi:10.1161/01.res.62.2.185 · Cited by 418
Freiman, P. C., Mitchell, G. G., Heistad, D. D., Armstrong, M. L., & Harrison, D. G. (1986) · Circulation Research · doi:10.1161/01.res.58.6.783 · Cited by 405
Cited by
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Endothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749
Self-citationImproved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve
Murthy, V. L., Naya, M., Foster, C. R., Hainer, J., Gaber, M., Di Carli, G., Blankstein, R., Dorbala, S., Sitek, A., Pencina, M. J., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.050427 · Cited by 850
Chronic Heart Failure in the United States: A Manifestation of Coronary Artery Disease
Gheorghiade, M., & Bonow, R. O. (1998) · Circulation · doi:10.1161/01.cir.97.3.282 · Cited by 787
Metadata
- Authors
- Cox, D. A., Vita, J. A., Treasure, C. B., Fish, R. D., Alexander, R. W., Ganz, P., & Selwyn, A. P.
- Venue
- Circulation
- Published
- 1989-09
- Volume
- 80
- Issue
- 3
- Pages
- 458-465
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2087375327
- Cited by
- 414
- References
- 20
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cox, D. A., Vita, J. A., Treasure, C. B., Fish, R. D., Alexander, R. W., Ganz, P., & Selwyn, A. P. (1989). Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation. https://doi.org/10.1161/01.cir.80.3.458
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
