Cited by 739Atrial Fibrillation Management and OutcomesCardiovascular Function and Risk FactorsCardiac Arrhythmias and Treatments

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Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study.

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Sanfilippo, A J, Abascal, V M, Sheehan, M, Oertel, L B, Harrigan, P, Hughes, R A, Weyman, A E·1990·Circulation

DOI 10.1161/01.cir.82.3.792

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Abstract

To test the hypothesis that atrial enlargement can develop as a consequence of atrial fibrillation, left and right atrial dimensions were measured echocardiographically at two different time points in patients with atrial fibrillation. Patients were selected who initially had normal atrial sizes and who had no evidence of significant structural or functional cardiac abnormalities other than atrial fibrillation either by history or two-dimensional and Doppler echocardiography. Fifteen patients were studied (12 men and three women; mean age, 67.3 years). Average time between studies was 20.6 months. Three orthogonal left atrial dimensions and two right atrial dimensions were measured, and all were found to increase significantly between studies. Also, highly significant increases in calculated left atrial volume (from 45.2 to 64.1 cm3, p less than 0.001) and right atrial volume (from 49.2 to 66.2 cm3, p less than 0.001) were observed. The relative extents of left and right atrial volume increase did not differ, and left ventricular size did not change significantly between studies. These results indicate that atrial enlargement can occur as a consequence of atrial fibrillation. The maintenance of sinus rhythm, therefore, may prevent atrial enlargement and its adverse clinical effects.

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Kannel WB, Abbott RD, Savage DD, McNamara PM: Epide- miologic features of chronic atrial fibrillation: The Framing- ham study. N Engl J Med 1982;306:1018-1022
Wolf PA, Abbott RD, Kannel WB: Atrial fibrillation: A major contributor to stroke in the elderly. Arch Intem Med 1987; 147:1561-1564
Wolf PA, Kannel WB, McGee DL, Meeks SL, Bharucha NE, McNamara PM: Duration of atrial fibrillation and imminence of stroke: The Framingham study. Stroke 1983;14:664-667
Britton M, Gustafsson C: Non-rheumatic atrial fibrillation as a risk factor for stroke. Stroke 1985;16:182-188
Gajewski J, Singer'RB: Mortality in an insured population with atrial fibrillation. JAM4 1981;245:1540-1544
Probst P, Goldschlager N, Selzer A: Left atrial size and atrial fibrillation in mitral stenosis. Circulation 1973;48:1282-1287
Petersen P, Kastrup J, Brinch K, Godtfredsen J, Boysen G: Relation between left atrial dimension and duration of atrial fibrillation. Am J Cardiol 1987;60:382-384'
Henry WL, Morganroth J, Pearlman AS, Clark CE, Redwood DR, Itscoitz SB, Epstein SE: Relation between echocardio- graphically determined left atrial size and atrial fibrillation. Circulation 1976;53:273-279
Keren G, Etzion T, Sherez J, Zelcer AA, Megidish R, Miller HI, Laniado S: Atrial fibrillation and atrial enlargement in patients with mitral stenosis. Am Heart J 1987;114:1146-1155
Brand FN, Abbott RD, Kannel WB, Wolf PA: Characteristics and prognosis of lone atrial fibrillation. JAMA 1985; 254:3449-3453
Kopecky SL, Gersh BJ, McGoon MD, Whisnant JP, Holmes DR, Ilstrup DM, Frye RL: The natural history of lone atrial fibrillation: A population based study over three decades. N Engl J Med 1987;317:669-674
Brand FN, Wolf PA, Kannel WB: Clinical significance of lone atrial fibrillation. Pract Cardiol 1987;13:85-93
Hoglund C, Rosenhamer G: Echocardiographic left atrial dimension as a predictor of maintaining sinus rhythm after conversion of atrial fibrillation. Acta Med Scand 1985; 217:411-415
Hinton RC, Kistler JP, Fallon JT, Friedlich AL, Fisher CM: Influence of atrial fibrillation on incidence of systemic embo- lism. Am J Cardiol 1977;40:509-513
Triulzi M, Gillam LD, Gentile F, Newell JB, Weyman AE: Normal adult cross-sectional echocardiographic values: Linear dimensions and chamber areas. Echocardiography 1984; 1:403-426
Sahn DJ, DeMaria A, Kisslo J, Weyman AE: The committee on M-mode standardization of the American Society of Echo- cardiography: Recommendations regarding quantitation in M-mode echocardiography and results of a survey of echocar- diographic measurements. Circulation 1978;58:1072-1081
Davies MJ, Pomerance A: Pathology of atrial fibrillation in man. Br Heart J 1972;34:520-525
Bailey GWH, Braniff BA, Hancock EW, Cohn KE: Relation of left atrial pathology to atrial fibrillation in mitral valvular disease. Ann Int Med 1968;69:13-20
Manning WJ, Leeman DE, Gotch RJ, Come PC: Pulsed Doppler evaluation of atrial mechanical function after electri- cal cardioversion of atrial fibrillation. J Am Coll Cardiol 1989;13:617-623
Skinner NS, Mitchell JH, Wallace AG, Sarnoff SJ: Hemody- namic consequences of atrial fibrillation at constant ventricu- lar rates. Am J Med 1964;36:342-550
White CW, Kerber RE, Weiss HR, Marcus ML: The effects of atrial fibrillation on atrial pressure-volume and flow relation- ships. Circ Res 1982;51:205-215
Shapiro W, Klein G: Alterations in cardiac function immedi- ately following electrical conversion of atrial fibrillation to normal sinus rhythm. Circulation 1968;38:1074
Somerville W, Chambers RJ: Systemic embolism in mitral stenosis: Relation to the size of the left atrial appendix. BrMed J 1964;2:1167-1169
Madden JL: Resection of the left auricular appendix. JAMA 1949;140:769-772
Bailey CP, Olsen AK, Keown KK, Nichols HT, Jamison WL: Commissurotomy for mitral stenosis: Technique for preven- tion of cerebral complications. JAMA 1952;149:1085-1091
Caplan LR, D'Cruz I, Hier DB, Reddy H, Shah S: Atrial size, atrial fibrillation, and stroke. Ann Neurol 1986;19:158-161
Wiener I, Hafner R, Nicolai M, Lyons H: Clinical and echocardiographic correlates of systemic embolization in non- rheumatic atrial fibrillation. Am J Cardiol 1987;59:177
Ruocco NA, Most AS: Clinical and echocardiographic risk factors for systemic embolization in patients with atrial fibril- lation in the absence of mitral stenosis (abstract). J Am Coll Cardiol 1986;7:165A
Tegeler CH, Hart RG: Atrial size, atrial fibrillation and stroke. Ann Neurol 1987;21:315-315
Dittrich HC, Erickson JS, Schneiderman T, Blacky AR, Savides T, Nicod PH: Echocardiographic and clinical predic- tors for outcome of elective cardioversion of atrial fibrillation. Am J Cardiol 1989;63:193-197 KEY WORDS * echocardiography embolization * atrial fibrillation

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Defauw, J. A. M., van Hemel, N. M., Kingma, J. H., Jaarsma, W., Vermeulen, F. E. E., de Bakker, J. M. T., & Guiraudon, G. M. (1992) · Developments in cardiovascular medicine · doi:10.1007/978-94-011-1816-3_10 · Cited by 4
Short term hemodynamic effects of atrial fibrillation in a closed-loop human cardiac-baroreflex system
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The assessment of atrial function by velocity-encoded magnetic resonance imaging
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“where V1 = three-chamber view height, V2 = fourchamber view width and V3 = four-chamber view length [12].”
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Stroke Prevention in Atrial Fibrillation in Heart Failure
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Maarouf, N., Arno, G., Carter, N. D., Syrris, P., Yusuf, S., Camm, A. J., POLEINIKI, J., & Al‐Saady, N. (2004) · Clinical Science · doi:10.1042/cs20030252 · Cited by 3
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Different Characteristics, Clinical Outcomes, and Left Atrial Reverse Remodeling in Patients with Mitral Stenosis Maintaining Sinus Rhythm for at Least 10 Years after Successful Percutaneous Mitral Valvuloplasty
Cho, I., Kim, S.-J., Han, D., et al. (2018) · Cardiology · doi:10.1159/000486708 · Cited by 3
Role of the Left Atrium
Macciò, S., & Marino, P. N. (2008) · Springer eBooks · doi:10.1007/978-1-84628-891-3_4 · Cited by 3
Atrial Tachycardia and Congestive Heart Failure:
Stambler, B. S. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.04336.x · Cited by 3
HUBUNGAN ANTARA HIPERTENSI DAN HIPERTROFI VENTRIKEL KIRI PADA PASIEN LANSIA DENGAN ATRIAL FIBRILASI
Damayanti, B. D. B., & Limantoro, C. (2014) · Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) · Cited by 3
Echocardiographic Predictors of Symptomatic Atrial Fibrillation In Patients with Rheumatic Mitral Stenosis and Normal Sinus Rhythm.
Ağca, F. V., Kınay, O., Karaca, M., et al. (2008) · PubMed · doi:10.4022/jafib.97 · Cited by 3
Remodelado anatómico auricular tras la cirugía de la valvulopatía mitral con fibrilación auricular permanente
Sos, F. H., Argudo, J. A. M., López, S. J. C., et al. (2003) · Revista Española de Cardiología · doi:10.1016/s0300-8932(03)76938-3 · Cited by 3
Novas Idéias Sobre os Mecanismos Eletrofisiológicos da Fibrilaçao Atrial suas Implicaçoes Terapêuticas
Fenelon, G., & de Paola, Â. A. V. (2000) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 3
Exercise Capacity Correlates With Left Atrial Structural Remodeling as Detected by Late Gadolinium-Enhanced Cardiac Magnetic Resonance in Patients With Atrial Fibrillation
Rizvi, K., Burgon, N. S., King, J. B., et al. (2016) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2016.03.012 · Cited by 3
“Antiarrhythmic drugs 5 (11) 9 (16) 7 (29) 1 (8) 0.”
Background
An unexpected complication of acute pancreatitis: Intra-cardiac thrombus
Keskin, M., Gümüşdağ, A., Börklü, E. B., et al. (2016) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2016.11.034 · Cited by 3
Effect of fibrillatory wave amplitude on coronary blood flow as assessed by thrombolysis in myocardial infarction frame count in patients with atrial fibrillation
Sumimoto, Y., Kurisu, S., Hitta, K., Ikenaga, H., Ishibashi, K., Fukuda, Y., Nakano, Y., & Kihara, Y. (2018) · Heart and Vessels · doi:10.1007/s00380-018-1121-9 · Cited by 3
Chemoreflexsensitivity among patients with paroxysmal atrial fibrillation
Budeus, M., Hennersdorf, M., & Perings, C. (2003) · Zeitschrift für Kardiologie · doi:10.1007/s00392-003-0952-1 · Cited by 3
“Furthermore atrial fibrillation can lead to a larger left atrial size (20), although we observed only a tendency for this (41.”
Background
Left atrial myxoma simulating a systemic disease with pleural-pericardial effusion. Detection by two-dimensional echocardiography.
Sanna, A., Porcu, M., Basciu, M., et al. (1990) · PubMed · Cited by 3
Pathophysiology of Atrial Fibrillation
Burashnikov, A., & Antzelevitch, C. N. (2017) · Cardiovascular medicine · doi:10.1007/978-3-319-58000-5_2 · Cited by 3
Angiotensin II receptor blockers in the prevention of complications from atrial fibrillation
Eide, S. (2009) · Vascular Health and Risk Management · doi:10.2147/vhrm.s7616 · Cited by 3
In-Vivo Models of Atrial Fibrillation
Schotten, U., Blaauw, Y., & Allessie, M. A. (2006) · Springer eBooks · doi:10.1007/3-540-26574-0_8 · Cited by 3
Review: Optimizing the Management of Atrial Fibrillation: Focus on Current Guidelines and the Impact of New Agents on Future Recommendations
Naccarelli, G. V., & Curtis, A. B. (2010) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248410370964 · Cited by 3
The three-dimensional substrate of atrial fibrillation in the goat : a simultaneous endo-epicardial mapping study
Eckstein, J. (2012) · doi:10.26481/dis.20120118je · Cited by 3
Renin-angiotensin-aldosterone system blockade in atrial fibrillation and left atrial remodelling
Krishnamoorthy, S., & Lip, G. Y. H. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02083.x · Cited by 3
Optimal Management of the Patient with an Episode of Atrial Fibrillation In and Out of the Hospital
Knight, B. P., & Morady, F. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb00696.x · Cited by 3
Should patients with lone atrial fibrillation be treated with anticoagulant therapy?
Lui, C. Y. (1991) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(10)80252-9 · Cited by 3
The Fibrillatory Wave Amplitude of ECG Decreases Over Time in Patients With Persistent AF: A Retrospective Cohort Study
Li, J., Wang, L., Guo, L., et al. (2026) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.70161 · Cited by 2
“Ultimately, it will impact the morphology of the surface ECG. Previous studies have analyzed the echocardiographic, Sanfilippo et al.'s (1990) results indicate that atrial enlargement can occur as a consequence of AF, one study revealed larger LA size is associated with fine AF amplitude (Nault et…”
Predictors of the Development of Significant Tricuspid Regurgitation after Permanent Pacemaker Implantation
Lee, K. J., Kim, K. H., Yim, Y. R., et al. (2014) · Korean Journal of Medicine · doi:10.3904/kjm.2014.86.5.577 · Cited by 2
“또한 심장 초음파 소견에서 중등도 이상의 삼첨판 역류증이 악화된 환자에서 유의한 좌심방 확장증 소견이 관 찰되었고 좌심방 확장이 독립적인 심방세동의 관련 요인이 며 좌심방 확장증이 심방세동이 동반된 환자에서 뇌졸중의 발생 가능성을 증가시킨다는 점에서 심방세동과 삼첨판 역 류증의 악화 및 예후에 대한 관련성을 추정해 볼 수 있었다 [17-20].”
Higher Pulmonary Arterial Pressure Was Related to Non-Pulmonary Vein Atrial Tachyarrhythmia
Lee, W., Watanabe, M., Yokoshiki, H., et al. (2020) · International Heart Journal · doi:10.1536/ihj.20-214 · Cited by 2
Management strategies and outcomes of thromboembolism prevention in atrial fibrillation co-existing with immune thrombocytopenia: A review of evidence
Metwally, O. H., Rahhal, A. A. A., elsherif, R., Elshoeibi, A. M., Elhadary, M. R., Elshoeibi, A. M., Badr, A. A., Elsayed, B., Al‐Rasheed, M., Alshurafa, A., et al. (2024) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2024.101493 · Cited by 2
“These complications arise from AF leading to blood stasis in the left atrial appendage [7] eventually leading to atrial enlargement [8].”
Background
High prevalence of atrial conduction abnormalities in Lewy body disease – a marker of cardiac complications?
Javanshiri, K., Siotis, A., Heyman, I., et al. (2025) · GeroScience · doi:10.1007/s11357-024-01479-4 · Cited by 2
“Hypertension and atrial fibrillation (AF) are associated with atrial enlargement, and atrial enlargement has a mutually perpetuating relationship with AF [8, 9].”
Gender Specific Characteristics of Ventricular-Atrial Remodeling in Recurrent Atrial Fibrillation in Ischemic Heart Disease Patients With Arterial Hypertension
Kobalava, Z. D., Кохан, Е. В., Kiyakbaev, G., & Анатольевич, Ш. А. (2017) · Kardiologiia · doi:10.18087/cardio.2017.12.10063 · Cited by 2
Mechanism of improvement in atrial functional mitral regurgitation after catheter ablation for atrial fibrillation: Three‐dimensional analysis using multislice computed tomography
Tsujisaka, Y., Kaji, S., Kim, K., et al. (2021) · Journal of Cardiac Surgery · doi:10.1111/jocs.16120 · Cited by 2
Thrombogenesis in Atrial Fibrillation
Ahmed, H. M. (2013) · InTech eBooks · doi:10.5772/53613 · Cited by 2
“Abnormal blood stasis In addition to stasis consequent on the failure of atrial systole, the presence of non-valvular atrial fibrillation seems to promote progressive left atrial (LA) dilatation [20], thus amplify‐ ing the potential for stasis.”
Background
Efficacy of Amiodarone in Tachycardia Induced Cardiomyopathy due to Non-Valvular Atrial Fibrillation
Yom, H. J., Park, S., Jeon, S. H., et al. (2001) · Korean Circulation Journal · doi:10.4070/kcj.2001.31.12.1305 · Cited by 2
Detection of atrial electrical instability in hypertensive patients
Oręziak, A., Niemczyk, L., Piątkowska-Janko, E., et al. (2003) · Computers in cardiology · doi:10.1109/cic.2003.1291216 · Cited by 2
Left atrial and left atrial appendage function in paroxysmal atrial fibrillation
Erdei, T., Dénes, M., Kardos, A., Foldesi, C., Temesvari, A., & Lengyel, M. (2011) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.98.2011.2.5 · Cited by 2
A beneficial effect of 3-year spironolactone therapy supplementing atenolol therapy on the remodeling of atria and ventricles in a patient with permanent atrial fibrillation
Dąbrowski, R., Sosnowski, C., Michalak, E., et al. (2009) · Internal and Emergency Medicine · doi:10.1007/s11739-009-0229-4 · Cited by 2
“Lack of the hemodynamically effective systole of atria synchronized with the systole of ventricles and a consequent chaotic rhythm of the ventricles result in the volumetric overload of the cardiac chambers, reduced diastolic filling and reduced stroke volume [1].”
Background
The additive value of three-dimensional derived left atrial volume and carotid imaging in dobutamine stress echocardiography
Sachpekidis, V., Bhan, A., Paul, M., et al. (2010) · European Journal of Echocardiography · doi:10.1093/ejechocard/jeq104 · Cited by 2
The Role of Echocardiography in Atrial Fibrillation and Flutter
Manning, W. J. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-3640-1.50045-9 · Cited by 2
Sinus rhythm restoration after left atrial reduction
Lednev, P. V., IuV, B., Komarov, R. N., et al. (2017) · Pirogov Russian Journal of Surgery · doi:10.17116/hirurgia2017280-82 · Cited by 2
Проґнозування тривалого утримання синусового ритму після кардіоверсії у пацієнтів з неклапанною персистентною фібриляцією передсердь
Zharinov, O. J., Левчук, Н. П., Икоркин, М. Р., et al. (2014) · Lviv clinical bulletin · doi:10.25040/lkv2014.04.008 · Cited by 2
Left atrial dilatation in undetermined group according to TOAST classification: echocardiographic assessment of stroke patients
Takoglu, A., & Can, U. A. (2013) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1208-60 · Cited by 2

Authors: Sanfilippo, A. J., Abascal, V. M., Sheehan, M., Oertel, L. B., Harrigan, P., Hughes, R. A., & Weyman, A. E.
Affiliations: Harvard University (US)
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1990-09
Volume: 82
Issue: 3
Pages: 792-797
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.82.3.792
OpenAlex: W2102450596
Cited by: 739
References: 0
Citations by year: 2026: 11 · 2025: 17 · 2024: 28 · 2023: 21 · 2022: 23 · 2021: 16 · 2020: 32 · 2019: 17 · 2018: 21 · 2017: 27 · 2016: 28 · 2015: 22 · 2014: 28 · 2013: 24 · 2012: 30
FWCI: 7.96
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords: atrial fibrillation, atrial enlargement, left atrial volume, right atrial volume, left atrial diameter, left ventricular dimensions, sinus rhythm maintenance, atrial remodeling
MeSH terms: Aged, Atrial Fibrillation, Echocardiography, Female, Heart Atria, Cardiomegaly, Heart Ventricles, Humans, Male, Middle Aged, Mitral Valve Insufficiency, Myocardium, Prospective Studies, Observer Variation

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Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study.

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