The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Cardiac electrophysiology of adenosine. Basic and clinical concepts.
Open accessAbstract
Adenosine is an endogenous nucleoside that has potent electrophysiologic effects.1-4As an antiarrhythmic agent, adenosine has several unique properties: 1) it is an intermediate metabolite (Figure 1), 2) it has a very short half-life (less than 1.5 seconds), 3) its effects are mediated by specific membrane receptors coupled to guanine nucleotide binding proteins (G proteins), and 4) it has sitespecific actions in the myocardium with important differential effects in supraventricular and ventricular tissue.'Adenosine also has an important role in regulating the myocardial oxygen supply-demand balance.Adenosine achieves this by increasing oxygen supply through coronary vasodilation and by reducing oxygen demand by decreasing myocardial contractility, antagonizing the effects of catecholamines, and de- pressing automaticity and conduction within the sinus and atrioventricular (AV) nodes.' Recently, the United States Food and Drug Admin- istration approved the use of adenosine for therapy of paroxysmal supraventricular tachycardia (PSVT), the first clinical application of adenosine.The purpose of this review is to present a rational approach for the therapeutic applications of adenosine for cardiac ar- rhythmias based on an understanding of its cellular and integrative mechanisms of action.Adenosine System The essential components of the adenosine system in the heart are 1) a mechanism for formation of adenosine, 2) a receptor-effector complex, and 3) a mechanism for the removal of adenosine and the attenuation of its actions (Figure 2).1'5-7From the Division of Cardiology, Department of Medicine (B.B.
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Cites
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The cardiac effects of adenosine
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Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G k
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Are Methylxanthine Effects Due to Antagonism of Endogenous Adenosine?
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Adenosine as inhibitor of myocardial effects of catecholamines
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Diagnostic and therapeutic use of adenosine in patients with supraventricular tachyarrhythmias
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Cited by
Chen, S. A., Chiang, C. E., Yang, C. J., Cheng, C. C., Wu, T. J., Wang, S. P., Chiang, B. N., & Chang, M. S. (1994) · Circulation · doi:10.1161/01.cir.90.3.1262 · Cited by 371
Syncope Due to Idiopathic Paroxysmal Atrioventricular Block
Brignole, M., Deharo, J.-C., De Roy, L., Menozzi, C., Blommaert, D., Dabiri, L., Ruf, J., & Guieu, R. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.045 · Cited by 147
Brignole, M., Gaggioli, G., Menozzi, C., Gianfranchi, L., Bartoletti, A., Bottoni, N., Lolli, G., Oddone, D., Rosso, A. D., & Pellinghelli, G. (1997) · Circulation · doi:10.1161/01.cir.96.11.3921 · Cited by 98
Differential effects of adenosine on focal and macroreentrant atrial tachycardia
MARKOWITZ, S. M., STEIN, K. M., MITTAL, S., SLOTWTNER, D. J., & LERMAN, B. B. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb00705.x · Cited by 88
Self-citationMechanism of syncope in patients with positive adenosine triphosphate tests
Donateo, P., Brignole, M., Menozzi, C., Bottoni, N., Alboni, P., Dinelli, M., Del Rosso, A., Croci, F., Oddone, D., Solano, A., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02621-9 · Cited by 68
Metadata
- Authors
- Lerman, B. B., & Belardinelli, L.
- Venue
- Circulation
- Published
- 1991-05
- Volume
- 83
- Issue
- 5
- Pages
- 1499-1509
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2089531408
- Cited by
- 377
- References
- 42
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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