The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection.
Open accessAbstract
BACKGROUND: Previous studies have demonstrated that heat-shock treatment results in the induction of 72-kD heat-shock protein (HSP72) and a reduction of infarct size after subsequent ischemia and reperfusion. METHODS AND RESULTS: To test the hypothesis that the degree of protection from ischemic injury in heat-shocked rats correlates with the degree of prior HSP72 induction, rats pretreated with 40 degrees C, 41 degrees C, or 42 degrees C of whole-body hyperthermia followed by 24 hours of recovery and control rats (n = 6 in each group) were quantitatively assessed for the presence of myocardial HPS72 by optical densitometry of Western blots and a primary antibody that is specific for HSP72 and a tertiary antibody labeled with 125I. Although rats heat-shocked to 40 degrees C had no significant induction of myocardial HSP72, rats heat-shocked to 41 degrees C and 42 degrees C demonstrated progressively increased amounts of myocardial HSP72 compared with controls. Separate groups of rats heat-shocked to 40 degrees C (n = 16), 41 degrees C (n = 37), and 42 degrees C (n = 36) with 24 hours of recovery and controls (n = 26) were subjected to 35 minutes of left coronary artery occlusion and 120 minutes of reperfusion. Compared with control and 40 degrees C rats, there was progressive infarct size reduction, assessed by triphenyltetrazolium chloride staining, in rats that were heat-shocked to 41 degrees C and 42 degrees C. Furthermore, there was a direct correlation between the amount of HSP72 induced and the reduction in infarct size (r = .97, P = .037). CONCLUSIONS: These results suggest that the improved salvage after heat-shock pretreatment may be related to the amount of HSP72 induced before prolonged ischemia and reperfusion.
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Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat
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Exercise and myocardial tolerance to ischaemia-reperfusion
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Metadata
- Authors
- Hutter, M. M., Sievers, R. E., Barbosa, V, & Wolfe, C. L.
- Venue
- Circulation
- Published
- 1994-01
- Volume
- 89
- Issue
- 1
- Pages
- 355-360
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2003396317
- Cited by
- 356
- References
- 10
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hutter, M. M., Sievers, R. E., Barbosa, V, & Wolfe, C. L. (1994). Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection. Circulation. https://doi.org/10.1161/01.cir.89.1.355
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