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Cited by 123Cardiac Ischemia and ReperfusionCardiovascular and exercise physiologyCardiovascular Effects of Exercise

Exercise and myocardial tolerance to ischaemia-reperfusion

Lennon, S. L., Quindry, J. C., French, J. P., Kim, S., Mehta, J. L., Powers, S. K.·2004·Acta Physiologica Scandinavica
DOI 10.1111/j.1365-201x.2004.01346.x
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Abstract

UNLABELLED: It is well established that both short-term (1-5 days) and long-term (weeks to months) high intensity exercise (i.e. 70-75%VO2max) provides cardioprotection against ischaemia-reperfusion injury. However, it is unclear if moderate intensity exercise will also provide cardioprotection. AIM: Therefore, these experiments compared the protective effects of moderate vs. high intensity exercise in providing defense against ischaemia-reperfusion injury. METHODS: Male Sprague-Dawley rats were randomly assigned to one of three-experimental groups: (1) sedentary (control); (2) moderate intensity treadmill exercise (60 min day(-1) at approximately 55%VO2max); or (3) high intensity treadmill exercise (60 min day(-1) at approximately 75%VO2max). Hearts were exposed to 20 min of global ischaemia followed by 30 min reperfusion in an isolated working heart preparation. RESULTS: Compared with sedentary rats, both moderate and high intensity exercised rats maintained a higher (P < 0.05) percentage of pre-ischaemia cardiac output and cardiac work (cardiac output x systolic blood pressure) during reperfusion. No differences in the percent recovery of cardiac output and heart work existed (P > 0.05) between the two exercise groups. CONCLUSIONS: These data reveal that both moderate and high intensity exercise training provide equivalent protection against ischaemia-reperfusion injury.

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Authors
Lennon, S. L., Quindry, J. C., French, J. P., Kim, S., Mehta, J. L., & Powers, S. K.
Affiliations
University of Arkansas Medical Center (US)
Corresponding author
Powers, S. K.
ORCID
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
2004-09-27
Volume
182
Issue
2
Pages
161-169
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1111/j.1365-201x.2004.01346.x
OpenAlex
W2033221654
Cited by
123
References
31
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 8 · 2017: 7 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 5 · 2012: 8
FWCI
4.24
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL067855)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
exercise training, myocardial ischemia-reperfusion injury, cardioprotection, moderate-intensity exercise, high-intensity exercise, cardiac output, cardiac work, isolated working heart
MeSH terms
Animals, Antioxidants, Blood Pressure, Cardiac Output, Heart, Heat-Shock Proteins, L-Lactate Dehydrogenase, Male, Myocardium, Physical Conditioning, Animal, RNA, Messenger, Superoxide Dismutase, Myocardial Reperfusion Injury, Myocardial Ischemia, Rats, Sprague-Dawley, Ventricular Dysfunction, Left, HSP72 Heat-Shock Proteins, Rats

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