Cited by 109Renin-Angiotensin System StudiesBlood Pressure and Hypertension StudiesCardiovascular Function and Risk Factors

Plasma angiotensin II, predisposition to hypertension, and left ventricular size in healthy young adults

Harrap, Stephen B., Dominiczak, Anna F., Fraser, Robert, Lever, Anthony F., Morton, James J., Foy, Christopher J., Watt, Graham C.M.·1996·Circulation

Abstract

BACKGROUND: We studied the correlates of left ventricular mass (LVM) in 84 healthy young adults aged 16 to 24 years from the general population. Subjects were selected according to predisposition to hypertension into four groups with either high or low personal blood pressures and either high or low parental blood pressures. METHODS AND RESULTS: LVM was measured by echocardiography, and measurements of blood pressure, heart rate, body dimensions, and plasma concentrations of components of the renin-angiotensin system were made under resting conditions. LVM was similar in individuals predisposed to hypertension (high personal and parental blood pressures) and those with contrasting predisposition (low personal and parental pressures). Regression analysis of the combined groups showed that LVM correlated closely with body size, particularly lean body mass (r=.69, P<.0001) and systolic (r=.35, P<.0001) but not diastolic blood pressure. Plasma angiotensin II (r=.39, P<.0001), renin (r=.302, P<.01), and angiotensin-converting enzyme (r=.22, P<.05) showed significant correlation with LVM. Multiple regression analysis revealed that plasma angiotensin II was the most important component of the renin-angiotensin system and that its effect was independent of systolic blood pressure and body size. CONCLUSIONS: These findings provide evidence in humans that angiotensin II exerts a direct on myocardial size. This association may have important implications for the complications and treatment of left ventricular hypertrophy.

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Crossref · 10.1161/01.cir.93.6.1148

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  • The development of LVH has been attributed to many factors, including raised arterial pressure levels and growth-promoting substances such as angiotensin II, insulin-like growth factor-1 and circulating catecholamines.

    “The development of LVH has been attributed to many factors, including raised arterial pressure levels (resulting in increased myocardial workload) and growth-promoting substances such as angiotensin II, insulin-like growth factor-1 and circulating catecholamines (5–10).”

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Authors
Harrap, S. B., Dominiczak, A. F., Fraser, R., Lever, A. F., Morton, J. J., Foy, C. J., & Watt, G. C. M.
Affiliations
Western Infirmary (GB)
Venue
Circulation
Published
1996-03-15
Volume
93
Issue
6
Pages
1148-1154
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2010740097
Cited by
109
References
32
Citations by year
2025: 2 · 2024: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 7 · 2014: 1 · 2013: 3 · 2012: 6
FWCI
5.94
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
plasma angiotensin II, left ventricular mass, left ventricular hypertrophy, renin-angiotensin system, angiotensin-converting enzyme, renin, young adults, body size, lean body mass, systolic blood pressure
MeSH terms
Adolescent, Adult, Angiotensin II, Blood Pressure, Body Weight, Female, Humans, Hypertension, Peptidyl-Dipeptidase A, Male, Middle Aged, Regression Analysis, Renin, Renin-Angiotensin System, Hypertrophy, Left Ventricular

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