The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Comparative Effects of Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor on Coronary Collateral Development and the Arterial Response to Injury
Abstract
Background We have shown that the angiogenic peptides basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) enhance canine coronary collateral development when administered for ≥4 weeks. bFGF, a pluripotent mitogen of mesodermally derived cells, could theoretically exacerbate neointimal smooth muscle cell hyperplasia, a fundamental component of atherosclerosis. VEGF, an endothelial cell–specific mitogen and vascular permeability factor, could have deleterious effects related to vascular hyperpermeability. The present investigation had two aims: (1) to ascertain whether brief (7-day) systemic arterial treatment with bFGF or VEGF would improve myocardial collateral perfusion and (2) to determine whether these peptides induce neointimal accumulation in vivo. Methods and Results Dogs were subjected to ameroid-induced occlusion of the left circumflex coronary artery and randomized to bFGF 1.74 mg (n=9), VEGF 0.72 mg (n=9), or saline (n=10) as a daily left atrial bolus (days 10 to 16). Additional dogs were randomized to VEGF 0.72 mg (n=6) or saline (n=5); however, treatment was delayed by 1 week. Coincident with the institution of treatment, all dogs underwent balloon denudation injury of the iliofemoral artery. bFGF markedly increased maximal collateral flow but did not exacerbate neointimal accumulation. VEGF had no discernible effect on maximal collateral flow, but it exacerbated neointimal thickening after vascular injury. Conclusions Short-term treatment with bFGF enhanced collateral development without increasing neointimal accumulation at sites of vascular injury. Although VEGF did not increase collateral development as administered in this study, it significantly exacerbated neointimal accumulation. These data provide support for the clinical investigation of bFGF in selected patients with ischemic heart disease.
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Cites
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Cited by
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Polymeric Growth Factor Delivery Strategies for Tissue Engineering
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Metadata
- Authors
- Lazarous, D. F., Shou, M., Scheinowitz, M., Hodge, E., Thirumurti, V., Kitsiou, A. N., Stiber, J. A., Lobo, A. D., Hunsberger, S., Guetta, E., Epstein, S. E., & Unger, E. F.
- Venue
- Circulation
- Published
- 1996-09
- Volume
- 94
- Issue
- 5
- Pages
- 1074-1082
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2082157250
- Cited by
- 386
- References
- 28
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Comparative Effects of Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor on Coronary Collateral Development and the Arterial Response to Injury. https://app.cochat.ai/papers/10.1161/01.cir.94.5.1074
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- Lazarous, D. F., Shou, M., Scheinowitz, M., Hodge, E., Thirumurti, V., Kitsiou, A. N., Stiber, J. A., Lobo, A. D., Hunsberger, S., Guetta, E., Epstein, S. E., & Unger, E. F. (1996). Comparative Effects of Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor on Coronary Collateral Development and the Arterial Response to Injury. Circulation. https://doi.org/10.1161/01.cir.94.5.1074
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
