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Cited by 372Cardiovascular Health and Risk FactorsCardiac Health and Mental HealthLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Attenuated Progression of Coronary Artery Disease After 6 Years of Multifactorial Risk Intervention: Role of Physical Exercise

Niebauer, Josef, Hambrecht, Rainer, Velich, Tamás, Hauer, Klaus, Marburger, Christian, Kälberer, Barbara, Weiss, Claus, von Hodenberg, Eberhard, Schlierf, Günter, Schuler, Gerhard, Zimmermann, Rainer, Kübler, Wolfgang·1997·Circulation
DOI 10.1161/01.cir.96.8.2534
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Abstract

Background It was the aim of this study to assess the long-term effects of physical exercise and low-fat diet on the progression of coronary artery disease. At the beginning of the study, 113 male patients with coronary artery disease were randomized to an intervention group (n=56) or a control group (n=57); 90 patients (80%) could be reevaluated after 6 years. Methods and Results Patients in the intervention group (n=40) showed a reduction in total serum cholesterol (6.03±1.03 versus 5.67±1.01 mmol/L; P <.03) and triglyceride levels (1.94±0.8 versus 1.6±0.89 mmol/L; P <.005) and maintained their initial body mass index (26±2 versus 27±2 kg/m 2 ; P =NS), but results were not statistically different from the control group (n=50) (total serum cholesterol, 6.05±1.02 versus 5.79±0.88 mmol/L; triglycerides, 2.25±1.28 versus 1.85±0.96 mmol/L [both P =NS]; body mass index, 26±2 versus 28±3 kg/m 2 [ P <.0001]). In the intervention group, there was a significant 28% increase in physical work capacity (166±59 versus 212±89 W; P <.001), whereas values remained essentially unchanged in the control group (165±51 versus 170±60 W; P =NS; between groups, P <.05). In the intervention group, coronary stenoses progressed at a significantly slower rate than in the control group ( P <.0001). Energy expenditure during exercise was assessed in a subgroup; patients with regression of coronary stenoses spent an average of 1784±384 kcal/wk (≈4 hours of moderate aerobic exercise per week). Multivariate regression analysis identified only physical work capacity as independently contributing to angiographic changes. Conclusions After 6 years of multifactorial risk intervention, there is significant and persistent improvement in lipoprotein levels and physical work capacity, which results in a significant retardation of disease progression. These beneficial effects appear to be largely due to chronic physical exercise.

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Crossref · 10.1161/01.cir.96.8.2534

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Citations

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Research works printed but not linked: 15

  1. 10.1161/circ.89.3.8124838 · DOI
  2. 10.1161/circ.91.10.2528 · DOI
  3. 10.1161/circ.87.6.8504494 · DOI
  4. 10.1161/circ.80.2.2665973 · DOI
  5. 10.1161/circ.94.4.857 · DOI
  6. 10.1161/circ.86.1.1617762 · DOI
  7. 10.1161/res.74.2.7507417 · DOI
  8. 10.1161/circ.94.7.1682 · DOI
  9. 10.1161/circ.86.4.1394936 · DOI
  10. 10.1161/atv91.11.2.1847823 · DOI
  11. 10.1161/atvb.16.1.44 · DOI
  12. 10.1161/circ.57.3.624167 · DOI
  13. 10.1161/circ.60.1.445714 · DOI
  14. 10.1161/circ.65.5.7074751 · DOI
  15. 10.1161/circ.64.6.7296787 · DOI

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Metadata

Authors
Niebauer, J., Hambrecht, R., Velich, T., Hauer, K., Marburger, C., Kälberer, B., Weiss, C., von Hodenberg, E., Schlierf, G., Schuler, G., Zimmermann, R., & Kübler, W.
Affiliations
  • Heidelberg University (DE)
  • From Medizinische Universitätsklinik Heidelberg, Abteilung Innere Medizin III–Kardiologie (J.N., T.V., K.H., C.M., B.K., C.W., G. Schlierf, R.Z., W.K.), Heidelberg, Germany; Herzzentrum der Universität Leipzig (R.H., G. Schuler), Abteilung Innere Medizin–Kardiologie, Leipzig, Germany; and Herzzentrum Lahr (E. von H.), Abteilung Kardiologie, Lahr, Germany.
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-10-21
Volume
96
Issue
8
Pages
2534-2541
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.96.8.2534
OpenAlex
W2085122671
Cited by
372
References
43
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 14 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 18
FWCI
5.71
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
coronary artery disease, physical activity, low-fat diet, coronary stenosis progression, physical work capacity, serum cholesterol, triglycerides, body mass index, energy expenditure, male patients, lipoproteins, aerobic exercise, energy balance, smoking cessation, alcohol consumption reduction, blood pressure reduction, lipid lowering
MeSH terms
Adult, Aged, Cholesterol, Coronary Disease, Dietary Fats, Energy Metabolism, Cardiac Catheterization, Hemodynamics, Humans, Male, Middle Aged, Nicotine, Risk Factors, Smoking, Triglycerides, Exercise, Body Mass Index, Coronary Angiography

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