The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Prospective Study of Hyperhomocysteinemia as an Adverse Cardiovascular Risk Factor in End-Stage Renal Disease
Open accessAbstract
Background —Retrospective and case-control studies show that hyperhomocysteinemia is an independent risk factor for atherosclerosis in patients with end-stage renal disease. We studied prospectively the association between total homocysteine and cardiovascular outcomes. Methods and Results —In all, 167 patients (93 men, 74 women; mean age, 56.3±14.7 years) were followed for a mean duration of 17.4±6.4 months. Cardiovascular events and causes of mortality were related to total homocysteine values and other cardiovascular risk factors. Cox regression analysis was used to identify the independent predictors for cardiovascular events and mortality. Fifty-five patients (33%) developed cardiovascular events and 31 (19%) died, 12 (8%) of cardiovascular causes. Total plasma homocysteine values ranged between 7.9 and 315.0 μmol/L. Levels were higher in patients who had cardiovascular events or died of cardiovascular causes (43.0±48.6 versus 26.9±14.9 μmol/L, P =.02). The relative risk (RR) for cardiovascular events, including death, increased 1% per μmol/L increase in total homocysteine concentration (RR, 1.01; CI, 1.00 to 1.01; P =.01). Conclusions —These prospective observations confirm that hyperhomocysteinemia is an independent risk factor for cardiovascular morbidity and mortality in end-stage renal disease, with an increased RR of 1% per μmol/L increase in total homocysteine concentration. Interventional studies are needed to evaluate the possible effects of modifying this risk factor in these patients.
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Cites
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Hyperhomocyst(e)inemia Is Associated With Impaired Endothelium-Dependent Vasodilation in Humans
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Cited by
Homocysteine and Risk of Ischemic Heart Disease and Stroke: A Meta-analysis
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Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
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Zoccali, C., Bode-Böger, S. M., Mallamaci, F., Benedetto, F. A., Tripepi, G., Malatino, L. S., Cataliotti, A., Bellanuova, I., Fermo, I., Frölich, J. C., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07217-8 · Cited by 1,087
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Cardiovascular disease and chronic renal disease: A new paradigm
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Metadata
- Authors
- Moustapha, A., Naso, A., Nahlawi, M., Gupta, A., Arheart, K. L., Jacobsen, D. W., Robinson, K., & Dennis, V. W.
- Venue
- Circulation
- Published
- 1998-01-20
- Volume
- 97
- Issue
- 2
- Pages
- 138-141
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1983823485
- Cited by
- 405
- References
- 15
- FWCI
- 30.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Moustapha, A., Naso, A., Nahlawi, M., Gupta, A., Arheart, K. L., Jacobsen, D. W., Robinson, K., & Dennis, V. W. (1998). Prospective Study of Hyperhomocysteinemia as an Adverse Cardiovascular Risk Factor in End-Stage Renal Disease. Circulation. https://doi.org/10.1161/01.cir.97.2.138
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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